The discovery and conquest of Mexico, 1517-1521.

"Some extracts from the letters of Hernando Cortés are added to make clear the topography of the siege of the city."

Studii di bibliografia analitica. Francesco da Bologna incisore di caratteri mobili metallici da stampa nell' ultimo decennio del secolo XV e nel primo ventennio del XVI, e stampatore in Bologna negli anni 1516 e 1517, non potè essere Francesco Raibolini detto Il Francia.

Reissued 1882 with "Studio secondo" and "Studio terzo" as "Studii di bibliografia analitica. Tomo primo."

Drei Denkschriften über die orientalische Frage von Papst Leo X, König Franz I von Frankreich und Kaiser Maximilian I aus dem Jahre, 1517;

Mode of access: Internet.

Cronache Forlivesi dal 1476 al 1517.

Mode of access: Internet.

Frankreichs einfluss auf, und Beziehungen zu Deutschland, seit der Reformation bis zur ersten französischen Staatsumwälzung. (1517-1789)

1. Bd. Bis zum tode könig Heinrichs IV. 1845.--2. Bd. 1610 bis 1789. 1856.

Geschichte der Reformation zu Biberach vom Jahr 1517 bis zum Jahr 1650.

Mode of access: Internet.

Disquisitionis de vita Desiderii Erasmi specimen ab ann. nat. usque ad annum 1517 ...

Vita.

The history of the Puritans; or, Protestant non-conformists; from the reformation in 1517, to the revolution in 1688; comprising an account of their principles; their attempts for a farther reformation in the church, their sufferings, and the lives and characters of their most considerable divines.

"Supplement, containing a sketch of the history of the Baptist and Quakers": v. 3, p. [329]-477.

Canzoni, sonetti, strambotti et frottole; libro tertio (Andrea Antico, 1517)

Composers named: Alessandro Mantoano, Bartolomeo Tromboncino, Marco Cara, Charpentras, Andrea Antico da Montona, Don Michele Vicentino, Filippo de Lurano.

The history of the Puritans : or, Protestant nonconformists : from the Reformation in 1517, to the Revolution in 1688 : comprising an account of their principles ... /

Includes bibliographical references and index.

Johannis Nideri theolgiolim clarissimi De visionibus ac revelationibus : opus rarissimum historiis Germaniæ refertissimum, anno 1517, Argentinæ editum : anspiciis serenissimi principis ac domini Dn. Rudolphi Augusti, Brunsvicens, ac Luneburg ducis : /

Pages [670]-[672] blank.

Prospects For Early Investigational Therapies For Sickle Cell Disease.

Sickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal hemoglobin that polymerizes at low oxygen concentrations, causing the erythrocyte to adopt a sickle-shaped morphology. SCD pathophysiology is extremely complex and can lead to numerous clinical complications, including painful vaso-occlusive crises (VOC), end-organ damage, and a shortened lifespan. An impressive number of investigational drugs are currently in early stages of clinical development with prospects for use either as chronic therapies to reduce VOC frequency and end-organ damage in SCD or for use at the time of VOC onset. Many of these agents have been developed using a pathophysiological-based approach to SCD, targeting one or more of the mechanisms that contribute to the disease process. It is plausible that a multi-drug approach to treating the disease will evolve in the coming years, whereby hydroxyurea (HU) (the only drug currently FDA-approved for SCD) is used in combination with drugs that amplify nitric oxide signaling and/or counteract hemolytic effects, platelet activation and inflammation.

Estudo inicial da degradação in vivo de poli(L-co-D,L ácido lático), sintetizado em laboratório, aplicado como prótese tibial em coelhos

The copolymer poly (L-co-D,L lactic acid), PLDLA, has gained prominence in the field of temporary prostheses due to the fact that their time of degradation is quite compatible with the requirement in the case of osseous fracture. In this work the in vivo degradation of devices from copolymer, as a system of plates and screws, used in fixation of the tibia of rabbits was studied. The devices were implanted in 15 adult rabbits, albinos, New Zealand race, and they were used as control devices of alloys of titanium (Ti-6Al-4V/ V grade). The use of copolymers, synthesized in the laboratory, was tested in the repair of fracture in rabbits'tibias, being assessed in the following times: 2 weeks, 2 months and 3 months. Morphological analysis of tissue surrounding the plate and screw system, for 2 weeks of implantation, showed the presence of osteoblasts, indicating a pre bone formation. After 2 months there was new bone formation in the region in contact with the polymer. This bone growth occurred simultaneously with the process of PLDLA degradation, invading the region where there was polymer and after 3 months there was an intense degradation of the copolymer and hence greater tissue invasion compared to 2 months which characterized bone formation in a region where the polymer degraded. The in vivo degradation study of the devices for PLDLA by means of histological evaluations during the period of consolidation of the fracture showed the efficiency of plate and screw system, and it was possible to check formation of bone tissue at the implantation site, without the presence of inflammatory reaction