A preference-based semantics for CTD reasoning

In [8] the authors developed a logical system based on the definition of a new non-classical connective ⊗ capturing the notion of reparative obligation. The system proved to be appropriate for handling well-known contrary-to-duty paradoxes but no model-theoretic semantics was presented. In this paper we fill the gap and define a suitable possible-world semantics for the system for which we can prove soundness and completeness. The semantics is a preference-based non-normal one extending and generalizing semantics for classical modal logics.

Signatures of superconducting and pseudogap phases in ultrafast transient reflectivity of Ca(Fe0.927Co0.073)(2)As-2

We present femtosecond time-resolved pump-probe spectroscopic studies of a pseudogap (PG) along with the superconducting (SC) gap in an overdoped iron pnictide Ca(Fe0.927Co0.073)(2)As-2. It is seen that the temperature evolution of the photo-excited quasiparticle (QP) relaxation dynamics, coherently excited A(1g)-symmetric optical phonon and two acoustic phonon dynamics behave anomalously in the vicinity of the superconducting transition temperature T-c. A continuous change in the sign of the experimentally measured transient differential reflectivity Delta R/R signal at the zero time delay between the pump and probe pulses at a temperature of similar to 200K is inferred as an evidence of the emergence of the PG phase around that temperature. This behavior is independent of the pump photon energy and occurs for crystals without the spin density wave phase transition. Copyright (C) EPLA, 2014

Teología, 1999, Tomo XXXVII nº 073 (número completo)

La Fides et ratio y “la” filosofía / Ricardo Ferrara -- Breve panorama histórico de los problemas morales / Juan Carlos Meinville -- Moral ecológica / Andrés R. M. Motto -- Racionalismo y tradicionalismo en el Río de la Plata. Gustavo Minelli – José Manuel Estrada / Nestor Tomás Auza -- Notas bibliográficas -- Libros recibidos

Diário da Constituinte [gravação de vídeo] : [programa n. 073]

Na Comissão da Organização Eleitoral, Partidos e Garantias das Instituições da Assembleia Nacional Constituinte (ANC), todos os temas polêmicos serão discutidos duas vezes antes da votação final. São eles: o papel dos militares, criação de uma corte constitucional e a fixação dos tempos dos mandatos. Saulo Queiroz (PFL-MS) acredita que assim a participação será democrática. A Comissão de Sistema Tributário, Orçamento e Finanças quer acabar com a impunidade dos crimes de colarinho branco. O deputado Fernando Gasparian (PMDB-SP), relator da Comissão, propõe a punição rigorosa e o impedimento da União em assumir os prejuízos financeiros causados por eles. A Subcomissão dos Negros, Populações Indígenas, Pessoas Deficientes e Minorias reafirma e amplia o direito das minorias. José Carlos Sabóia (PMDB-MA) relata que caberá a Constituição e ao Tribunal Constitucional impedir qualquer prática de discriminação racial. Populares falam a respeito. Para os deficientes físicos, alguns direitos já estão garantidos no anteprojeto. Nelson Seixas (PDT-SP) afirma que agora as entidades responsáveis pelos interesses dos deficientes viverão um novo momento. Ione Pereira França, presidente da Associação dos Deficientes Físicos de Brasília, acredita que só através da implementação de leis haverá mudanças.

Nutrient Enhanced Coastal Ocean Productivity (NECOP). Data report: CTD and hydrographic data, R/V Pelican cruise, April 3-11, 1993

The Nutrient Enhanced Coastal Ocean Productivity (NECOP) Program is a component of NOAA's Coastal Ocean Program. The central hypothesis of this research is: Anthropogenic nutrient inputs have enhanced coastal ocean productivity with subsequent impacts on coastal ocean water quality, living resource yields, and the global marine carbon cycle. The initial study area for this program is the Mississippi/Atchafalaya River Outflow and adjacent Louisiana shelf region.

Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.

BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1). Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. Furthermore, enhanced P-CTD cleavage was observed in both yeast and human breast cells following UV-irradiation indicating a conserved eukaryotic damage response. Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression.