Long-term outcome of patients with clinical stage I high-risk nonseminomatous germ-cell tumors 15 years after one adjuvant cycle of bleomycin, etoposide, and cisplatin chemotherapy

BACKGROUND To report the long-term results of adjuvant treatment with one cycle of modified bleomycin, etoposide, and cisplatin (BEP) in patients with clinical stage I (CS I) nonseminomatous germ-cell tumors (NSGCT) at high risk of relapse. PATIENTS AND METHODS In a single-arm, phase II clinical trial, 40 patients with CS I NSGCT with vascular invasion and/or >50% embryonal cell carcinoma in the orchiectomy specimen received one cycle of adjuvant BEP (20 mg/m(2) bleomycin as a continuous infusion over 24 h, 120 mg/m(2) etoposide and 40 mg/m(2) cisplatin each on days 1-3). Primary end point was the relapse rate. RESULTS Median follow-up was 186 months. One patient (2.5%) had a pulmonary relapse 13 months after one BEP and died after three additional cycles of BEP chemotherapy. Three patients (7.5%) presented with a contralateral metachronous testicular tumor, and three (7.5%) developed a secondary malignancy. Three patients (7.5%) reported intermittent tinnitus and one had grade 2 peripheral polyneuropathy (2.5%). CONCLUSIONS Adjuvant chemotherapy with one cycle of modified-BEP is a feasible and safe treatment of patients with CS I NSGCT at high risk of relapse. In these patients, it appears to be an alternative to two cycles of BEP and to have a lower relapse rate than retroperitoneal lymph node dissection. If confirmed by other centers, 1 cycle of adjuvant BEP chemotherapy should become a first-line treatment option for this group of patients.

Ms. germ. qu. 147 - Protokollbuch der Deputation 1698 - 1700

Vorbesitzer: Johann Hieronymus Zum Jungen;

Ms. germ. oct. 207 - Eine Vermutung über den Ursprung der Stadt Meiningen (Gedruckt in der Zeitschrift des Hennebergischen Altertumsforschenden Vereins 1839)

Vorbesitzer: Georg Karl Wilhelm Philipp Donop

Ms. germ. fol. 12 - Weltchronik

Vorbesitzer: Antiquariat K. W. Hiersemann, Leipzig

Ms. germ. fol. 16 Bd. 2 - Vollständiges Register über des (... ?) Reichs-Statt Franckfurt ernewerte Reformation de Anno 1611. Nach Ordnung des Alphabets aufgerichtet

Alte Signatur: Ffm. Q 1/81; Akzessionsnummer: 54/20x1

Ms. germ. oct. 31 (Ausst. 38) - Leben und Leiden Christi. Gebete

Vorbesitzer: Johann Maximilian zum Jungen

Ms. germ. oct. 3 - Gebetbuch des Claus Humbracht

Vorbesitzer: Claus Humbracht; Joseph von Humbracht; Stadtarchiv Frankfurt am Main

Ms. germ. qu. 14 (Ausst. 48) - Rüst- und Feuerwerksbuch

Vorbesitzer: Ratsbibliothek Frankfurt am Main

Attenuated portal hypertension in germ-free mice: Function of bacterial flora on the development of mesenteric lymphatic and blood vessels

Intestinal bacterial flora may induce splanchnic hemodynamic and histological alterations that are associated with portal hypertension (PH). We hypothesized that experimental PH would be attenuated in the complete absence of intestinal bacteria. We induced prehepatic PH by partial portal vein ligation (PPVL) in germ-free (GF) or mice colonized with altered Schaedler's flora (ASF). After 2 or 7 days, we performed hemodynamic measurements, including portal pressure (PP) and portosystemic shunts (PSS), and collected tissues for histomorphology, microbiology, and gene expression studies. Mice colonized with intestinal microbiota presented significantly higher PP levels after PPVL, compared to GF, mice. Presence of bacterial flora was also associated with significantly increased PSS and spleen weight. However, there were no hemodynamic differences between sham-operated mice in the presence or absence of intestinal flora. Bacterial translocation to the spleen was demonstrated 2 days, but not 7 days, after PPVL. Intestinal lymphatic and blood vessels were more abundant in colonized and in portal hypertensive mice, as compared to GF and sham-operated mice. Expression of the intestinal antimicrobial peptide, angiogenin-4, was suppressed in GF mice, but increased significantly after PPVL, whereas other angiogenic factors remained unchanged. Moreover, colonization of GF mice with ASF 2 days after PPVL led to a significant increase in intestinal blood vessels, compared to controls. The relative increase in PP after PPVL in ASF and specific pathogen-free mice was not significantly different. CONCLUSION In the complete absence of gut microbial flora PP is normal, but experimental PH is significantly attenuated. Intestinal mucosal lymphatic and blood vessels induced by bacterial colonization may contribute to development of PH.

Ms. germ. fol. 44 - Beschreibung zum Gedenken des im Jahr 1785 viel und großen Schnees und lang aushaltender Kälte, als die Ursache der großen Ueberschwemmung der Oder bey Franckfurth und dem Unglücklichen Tode des Herzogs Maximilian Julius Leopold von Braunschweig und Lüneburg

Vorbesitzer: Friedrich Wilhelm Lua; Königlich Preussische Garnisonschule zu Frankfurt/Oder; alte Signatur: Tit.IV Nr. 1; Akzessionsnummer: 51/1040x1

Ms. germ. fol. 50 - Abschied der Sachsen, als sie aus Frankfurt zogen

Vorbesitzer: Adam Späth; Martin May; alte Signatur: Milit.Ff. 127; Akzessionsnummer: 2140/3

Ms. germ. qu. 10 - Liederbuch der Herzogin Amalia zu Cleve-Jülich-Berg

Vorbesitzer: Georg Kloß

Ms. germ. qu. 7 - Friedrich von Schwaben

Vorbesitzer: Kloster Bronnbach; Kloster Neustadt a.M.; Fürstlich Löwenstein-Rosenbergische Hofbibliothek Klein-Heubach