Planejamento, síntese e avaliação farmacológica de compostos híbridos potencialmente ativos para o tratamento da anemia falciforme

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo anatomorfológico, radiográfico e tomográfico de Schistosomus reflexus em ovino da raça Dorper: relato de caso

Schistosomus reflexus (SR) is a rare and fatal congenital anomaly, primarily observed in ruminants, presenting fetus with dorsiflexion of the vertebral column, exposure of thoracic and visceral organs, and scoliosis. A caesarian was performed on a Dorper sheep on a farm in Botucatu-SP and according to the general characteristics and findings observed in the necropsy of the fetus it was an SR case. The radiography indicated a marked ventro-dorsal deviation of the thoracolumbar column segment and deformity of the ribs. On the computed tomography the integrity of the bones and organs were detected, except for the absence of a lumbar vertebra. No data were available in the literature for SR diagnosis in sheep by image, so radiographic and tomographic exams of the fetus were done.

Potencial evocado auditivo para diagnóstico de surdez em gato com síndrome vestibular periférica

The brainstem auditory evoked potential is an electrodiagnostic test that allows a functional assessment of the auditory pathways from the middle ear to the brainstem. This test, in veterinary medicine, is not commonly used in Brazil. This paper reports the use of auditory evoked potential for deafness detection in a cat with unilateral peripheral vestibular syndrome secondary to otitis media.

Brainstem auditory evoked potential testing in Dalmatian dogs in Brazil

The brain stem auditory-evoked potential (BAEP) is an electrophysiologic test that detects and records the electrical activity in the auditory system from cochlea to midbrain, generated after an acoustic stimulus applied to the external ear. The aim of this study is to obtain normative data for BAEP in Dalmatian dogs in order to apply this to the evaluation of deafness and other neurologic disorders. BAEP were recorded from 30 Dalmatian dogs for a normative Brazilian study. Mean latencies for waves I, III, and V were 1.14 (±0.09), 2.62 (±0.10), and 3.46 (±0.14) ms, respectively. Mean inter-peak latencies for I-III, III-V, and I-V intervals were 1.48 (±0.17), 0.84 (±0.12), and 2.31 (±0.18) ms, respectively. Unilateral abnormalities were found in 16.7% of animals and bilateral deafness was seen in one dog. The normative data obtained in this paper is compatible with other published data. As far as we know this is the first report of deafness occurrence in Dalmatian dogs in Brazil.

O tratamento da doenca renal cronica pode afetar a audicao?

Introdução:Doença renal crônica (DRC) é definida pela presença de lesão renal levando à perda lenta e progressiva da função renal.Objetivo:Comparar testes auditivos entre pacientes com DRC submetidos a diferentes método de tratamento.Material e método:Estudo clínico transversal. Os grupos foram divididos de acordo com o método de tratamento: hemodiálise (n = 35), diálise peritoneal (n =15), conservador (n = 51) e 27 pacientes saudáveis (controle). Pacientes com idade superior a 60 anos, perda auditiva congênita, síndromes genéticas, infecções de orelha média e transplante renal foram excluídos da pesquisa. A avaliação audiológica incluiu audiometria tonal, emissões otoacústicas evocadas transientes e Potencial Evocado Auditivo de Tronco Encefálico (PEATE); e as variáveis avaliadas foram: sexo, idade, diagnóstico de hipertensão arterial e diabetes, estádio da DRC, tempo de diagnóstico do diabetes e da hipertensão arterial, duração da DRC e do tratamento.Resultados:A idade, presença de hipertensão arterial e tempo de DRC foram estatisticamente significantes e controlados. O grupo conservador apresentou piores limiares auditivos na audiometria tonal e o intervalo III-V do PEATE significativamente maior que o da hemodiálise.Conclusão:O tratamento conservador mostrou piores resultados na avaliação auditiva, independente de diabetes e de hipertensão, reforçando que os pacientes submetidos a tratamento para DRC devem realizar avaliação auditiva completa para melhor compreensão da doença e de seus efeitos sobre o sistema auditivo.

Achados timpanométricos em um grupo de escolares

PURPOSE: to characterize and compare the tympanometric findings in a group of preschoolers. METHOD: 112 preschoolers were evaluated, both genders, aged from four years old to five years and eleven months old who attended a Municipal School of Early Childhood Education in the suburbs of Marilia city- SP. Tympanometry was used as triage procedure. It was considered that the child PASSED in the triage when it presented an A type tympanometric curve, bilaterally, being reevaluated in case of failure. RESULTS: it was observed a high failure index (63.4%) in the studied population. The older female preschoolers presented a higher index of A type tympanograms, in both ears. There was a higher incidence of failure in male preschoolers aged from four years to four years and eleven months. CONCLUSION: in this sample, there was a high index of tympanometric alteration. There was a tendency among younger male students to present a higher index of tympanometric alteration when compared to older female preschoolers, this difference was not statistically significant.

Estudo da correlação linear entre a dimensão da largura maxilar e as dimensões das larguras de outras grandezas, lineares, transversas da face, em portadores de fissura transforame incisivo unilateral, através da cefalometria radiográfica, em norma frontal

This research presents the results of a cephalometric radiography study, in frontal norm, that was used to measure the possible linear correlations between several linear dimensions of the face, in a sample of a 140 caucasian brazilians, with an average age of 20 years, who were distributed in 2 groups as follows: Control group - formed of 35 males and 35 females, with no apparent facial deformities and with dental oclusion, not necessarily, in Angle's Class I; Unilateral cleft lip and palate group - formed of 35 males and 35 females with surgical correction of the up in the first year and of the palate until the third year of life, without orthodontic treatment. ln each teleradiography, the following parameters were measured using a computer: - Lateral orbit width or external orbit width (LOe) - Medial orbit width or internal orbit width (LOI) - Zygomatic width or facial width (LZI) - Mastold width (LMa) - Maxilar width (LMx) - Nasal width (LNa) - Condilar width (LCo) - Antigonial width (LGa) The values obtained were treated statistically using quantitative analysis (arithmetic mean, standard deviation, standard mean error, Person's variation factor and Pearson factor linear correlation). Theirs significance was established by Student's t test. The Pearson factor linear correlations determined between transverse linear cephalometric width dimensions of face in frontal norm for individuals of both groups and sex, with an average age of 20 years, were: ...

Avaliação dos níveis de resposta das emissões otoacústicas em neonatos com asfixia perinatal

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Ocorrência de ceceio em fricativas vozeadas e não vozeadas em crianças com fissura labiopalatina operada

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Long latency auditory evoked potential in Asperger Syndrome: two case studies

Introduction: Auditory Late Responses (ALR) assess central auditory processing by neuro electric activity of the auditory pathway and analyse the activities involved in cortical abilities of discrimination, attention and integration of the brain. Individuals withAsperger Syndrome experience changes in these skills, so it is important to research these potential this population. The objective of this paper was to describe the auditory late responses of two patients with Asperger Syndrome. Methods: The study included two male patients with Asperger Syndrome, of 7 and 12 years of age, treated in a study centre. The patients did not present any auditory complaint detected by an amnesis. The external auditory canal was inspected and audiological and auditory late responses assessed. After evaluation the components P2, N2 and P3 were analysed. Results: In both patients, the latency of the components P2, N2 and P3 were elongated in both ears. Regarding the amplitude of the P2 component, reduced values were found for the left ear of patient 1 and the right ear of patient 2. The N2 amplitude was reduced for both ears of patient 1 and only the right ear of patient 2. The two patients showed a decrease in the amplitude of the P3 only in the right ear. Conclusion:This study concludes that there were changes in the ALR results in both patients with Asperger Syndrome, suggesting alteration of the auditory function at the cortex level.

Avaliação audiológica em trabalhadores expostos a ruído e praguicida

Noise-induced hearing loss has been studied for many years and today many experts also investigate the synergic action of chemical products, since they can be potentially ototoxic. AIM: to investigate the audiological findings in workers exposed to occupational noise and pesticide and to compare it to data from noise-exposed workers. STUDY DESIGN: Clinical retrospective. MATERIAL AND METHOD: individuals that had been exposed to pesticide and noise (group I), and individuals that had been exposed to noise only (group II). RESULTS: The classification of the audiometric findings showed in that group I: 35% had normal hearing thresholds, 53.75% had degree 1 hearing loss and 11.25% had degree 2 hearing loss; and group II had 57.5% of normal hearing, 40% had degree 1 hearing loss and only 2.5% had degree 2 hearing loss. The analysis of the audiometric findings also showed a significant worsening after comparing groups I and II thresholds, in the frequency of 3 kHz on the left ear and 4 kHz on both ears. CONCLUSION: The analysis showed that group I had worse audiometric thresholds compared to group II.

Frontonasal dysplasia: clinical evaluation on audiological and brainstem electrophysiological profiles

Frontonasal dysplasia (FND) is a rare malformative complex affecting the frontal portion of the face, the eyes and the nose; it may occur singly or associated with other clinical signs. No systematic studies describing hearing in this condition were found. AIM: To evaluate hearing sensitivity and sound stimulus conduction from cochlea to brainstem in patients with clinical signs of FND. METHODS: 21 patients with isolated or syndromic FND were submitted to a clinical (otological/vestibular antecedents and otoscopy) and instrumental (pure tone and speech audiometry, tympanometry and brainstem auditory evoked response) hearing evaluation. DESIGN: A clinical, cross-sectional observational prospective study. RESULTS: Hearing thresholds were normal in 15 (70%) patients, abnormal in 5 (25%), mostly with conductive hearing loss; one patient did not cooperate with testing. The tympanometric curve was type A in 30 (72%) ears, type C in 5 (12%), type As in 4 (9%) and type B in 3 (7%). The auditory brainstem response (ABR) showed no abnormalities. CONCLUSION: Patients with FND showed no abnormalities in the auditory system from cochlea to brainstem in this study. Mild conductive hearing loss found in some is probably related to cleft palate. Further evaluation of hearing pathways at higher levels is recommended.

Potenciais evocados auditivos de longa latência em escolares com transtornos específicos de aprendizagem

Purpose: To study the components of long latency auditory evoked potentials and to compare data from these measures in students with and without learning disabilities. Method: Thirty students, 15 with learning disorder (study group) and 15 typical without learning problems (control group), of both genders, aged 7-14 years, mean age 10 years. They underwent clinical assessment in a clinic belonging to a public university in the state of São Paulo. Following, audiological assessment was performed to determine normal peripheral auditory system and electrophysiological assessment by examining the long latency auditory evoked response. Result: The results showed that there are functional differences between the groups. Increased latency components of long latency auditory evoked potential was observed in the study group compared to the control group. Longer latency values of these components were observed in the left ear when stimulated in the study group. Conclusion: This study contributed to better understanding of the auditory pathway functioning in children with learning disorders and can be a reference for other clinical and experimental studies and thus improve the definition of diagnostic criteria in this population.

Determinação da crítica razão esforço-pausa em Uchi-Komi no judô, com a utilização de deltas de variação de lactato sanguíneo e da escala subjetiva de esforço de Borg

In the competitive judo, the form as a trainer organizes the process of his/her athlete's training is a very important task for a good acting and a better use of the technical procedures. There is great importance in determining the exercise intensity for the judocas training due to the interest for the high income in several competitions, and few studies returned for this research area, involving those athletes' different physiologic conditions. Therefore, it is necessary to improve protocols of physical evaluation for this modality, increasing his/her applicability. The present study aimed at to verify the validity of a protocol of specific aerobic test of the judo (technique ipon-seoi-nague), no exhausting, adapted of the method of CHASSAIN (1986), using deltas of variations of the lactacidemia and of the Scale of Perception of Effort of Borg, in athletes well. The test adapted to the judo constituted of four exercise series with two efforts similar (double) of 180 seconds with one interval of 90 seconds among them. The series of exercises were accomplished in consecutive days. The intensities of the double tests were of 85%, 95%, 105% and 115% of the minimum lactato for each participant. This work used the technique ipon-seoi-nague, obeying the reasons effort-pause individualized for each athlete, that you/they correspond to the intensities of exercises proposed by the protocol of CHASSAIN (1986). In that way, the athletes applied a blow (maximum speed) and they rested some seconds, depending on the regime effort-pause of the session. At the end of each collection collection of blood (25NL) of each participant's earlobe was accomplished, seeking to measure the concentration of sanguine lactato. The collections were accomplished at the end of the first and of the second efforts, in each one of the series. For the analysis of the Perception of the athletes' Effort, the Scale of Perception... (Complete abstract click electronic access below)

Estudo e aplicação da técnica de vibroacustografia em ensaios não destrutivos

A presença de falhas, trincas, furos e fadigas causam perturbações nos modos vibracionais (normais) de uma estrutura, por exemplo, tubos, gasodutos e peças metálicas. Uma vez conhecido o espectro de freqüência de uma estrutura instalada em condições normais (sem falhas), é possível acompanhar através, de ensaios não destrutivos uma alteração no espectro de freqüência que pode estar associado a alguma falha mecânica na estrutura.O presente trabalho busca encontrar um padrão nos sinais de resposta dos materiais analisados pela técnica de Vibroacustografia, antes e depois das deformidades causadas. Tentando viabilizar a técnica para a utilização em Ensaios Não Destrutivos (END). E futuramente, para as amostras biológicas, espera-se estender os conhecimentos obtidos dos ensaios anteriores para detecção e prevenção de possíveis fraturas do tecido ósseo