Dilemas e hesitações da modernidade tardia e a emergência da sociedade de controle

The objective of this study is to emphasize the fundamental points of the theoretical discussion about late modernity. In the two last decades, authors like Giddens, Beck, Bauman, Sennett and Garland have emphasized the social, historical and theoretical characterization of modernity in the advanced occidental societies. This discussion, despite being indispensable, does not allow the comprehension of the problems of this new stage of occidental capitalism in terms of its technical dimension and social control. The article arguments in favor of the incorporation of analysis of Michel Foucault’s power and stresses its present reality and potential. This author renewed the theoretical possibilities of the human sciences as he criticized a naturalized view of History and historical events. The influence of his works, an analysis of modernity, may be observed in the debate around the crisis of modernity and the emerging society of control. At the same time, his work helps us understand the main dilemmas and hesitations of contemporary societies.

O retorno: identidades à deriva no romance português contemporâneo

This paper concentrates on the analysis of how the typical voices of History are manifested, which is achieved by the aesthetics of the contemporary Portuguese narrative, as it aims at the same time the reflexion and the reformulation of the Lusitanian cultural imaginary in the course of O retorno, a novel by Dulce Maria Cardoso. The hypothesis that arises is that the trajectory of Rui’s individual experience, as wells as the other’s characters “retornados” looking for identity, is parallel to the proposed revision of the Portuguese nation collective cultural imaginary in the decolonization context, after the 25th April Revolution. It is its objective to investigate how the historical processes concerned to the concepts of exile and uprooting, displacement and belonging (BAUMAN, 2005) are fictionalized in the novel, seen as motes for Rui’s pursuit for identity and for the revision of the Portuguese Destiny theme

Comunicação de marcas de moda: nova proposta para a ação do Relações Públicas

This study has the objective of presenting a new suggestion to the public relations professional into the Brazilian fashion business, seeing that, besides promising and little explored, presents social-economic conditions that allow the profession actuation. For this, it has been deeply analyzed the social character of fashion history e its development parallel to the society historical and economic transformations, basing, then, the study of fashion history in Brazil. To understand contemporaneity and the relations which interlace on it, there were used two analyzes about nowadays social order, liquid pos-modernity, from Bauman; and the hypermodernity, from Lipovetsky. In this context, it‟s approached new ways of relating with marks and with products which, since their consumption, are prepared to posterior discard. In the accelerated scenario of marks and consumption, the human relations, more liquids and tenuous, create the urgent possibility of action from on communication professional, who knows to identify the consumers desires and foresee their needs, rendering the tenuous laces stronger and the relationships more solid. This is when the profession of public relations presents itself as a new proposal to create experiences and to tight the loose laces on the consumption era

Players, Mao II e Falling Man: O terror em três versões (publicado em 2014)

This paper aims at analyzing the different approaches to terror in the novels Players (1977), Mao II (1991) and Falling Man (2007), by the American writer Don DeLillo. In Players, terror is shown as something attractive and exciting to a character who leads a very tedious personal and professional life; in Mao II, it is connected to the kidnapping of a poet and the text brings up relevant debates focusing on the contrast related to the power of novelists and terrorists in society; and in Falling Man, the author reviews the tragedy of September 11, in an attempt to try to understand the reasons why the attacks happened. The novels show terrorist actions connected to historical processes and also to the present form of capitalism and globalization. Theoretical texts by Bauman (1998), Eagleton (2005), Freitas (1989), Fraser (2000) will be used to discuss the issues addressed in this paper.

O teatro do oprimido como ferramenta educativa: ações junto aos adolescentes em estado de vulnerabilidade social

This article is a theoretical and practical portrait of a non-formal educational activities aimed to examine the transformations experienced by young people in a state of social vulnerability participating in social discussions in a form of theater of the oppressed - the theater-forum. The technique of theater-forum was held as a methodology able to establish a critical space action / reflection / action on the social reality experienced by these young people. The discussions postulates in some theatrical performances were analyzed critically and scored from theoretical frameworks of contemporary thinkers (Bauman, Augé, Boal,Bock, Aguiar, Ozella). We conclude that this action re-signified social problems (violence, drug involvement, hyperconsumerism, poverty, cultural capital etc.) Among these young people. In general, the young through a collective construction could experience new processes of subjectivity and open to possible changes and social transformations criticism in your life.

O teatro do oprimido como ferramenta psicoeducativa

This article is a theoretical and practical portrait of a non-formal educational activities aimed to examine the transformations experienced by young people in a state of social vulnerability participating in social discussions in a form of theater of the oppressed - the theater-forum. The technique of theater-forum was held as a methodology able to establish a critical space action / reflection / action on the social reality experienced by these young people. The discussions postulates in some theatrical performances were analyzed critically and scored from theoretical frameworks of contemporary thinkers (Bauman, Augé, Boal) and analysts sociohistorical (Bock, Aguiar, Ozella). We conclude that this action re-signified social problems (violence, drug involvement, hyper-consumerism, poverty, cultural capital etc.) among these young people. In general, the young through a collective construction could experience new processes of subjectivity and open to possible changes and social transformations criticism in your life.

Narrativas audiovisuais nas redes sociais: o consumo como elemento de identidade na campanha da Panvel

Pós-graduação em Comunicação - FAAC

O programa sala de leitura e seus reflexos nas histórias de leitura de alunos e professores de uma escola estadual paulista

Pós-graduação em Letras - FCLAR

Pertencer e deslocar virtualmente: Teletandem como espaço antropofágico

Pós-graduação em Estudos Linguísticos - IBILCE

Targeting the Transposase Domain of the DNA Repair Component Metnase to Enhance Chemotherapy

Previous studies have shown that the DNA repair component Metnase (SETMAR) mediates resistance to DNA damaging cancer chemotherapy. Metnase has a nuclease domain that shares homology with the Transposase family. We therefore virtually screened the tertiary Metnase structure against the 550,000 compound ChemDiv library to identify small molecules that might dock in the active site of the transposase nuclease domain of Metnase. We identified eight compounds as possible Metnase inhibitors. Interestingly, among these candidate inhibitors were quinolone antibiotics and HIV integrase inhibitors, which share common structural features. Previous reports have described possible activity of quinolones as antineoplastic agents. Therefore, we chose the quinolone ciprofloxacin for further study, based on its wide clinical availability and low toxicity. We found that ciprofloxacin inhibits the ability of Metnase to cleave DNA and inhibits Metnase-dependent DNA repair. Ciprofloxacin on its own did not induce DNA damage, but it did reduce repair of chemotherapy-induced DNA damage. Ciprofloxacin increased the sensitivity of cancer cell lines and a xenograft tumor model to clinically relevant chemotherapy. These studies provide a mechanism for the previously postulated antineoplastic activity of quinolones, and suggest that ciprofloxacin might be a simple yet effective adjunct to cancer chemotherapy. Cancer Res; 72(23); 6200-8. (C) 2012 AACR.

Synthese, 18 F-Markierung, 11 C-Markierung und Evaluierung Hydantoin-substituierter Indolcarbonsäuren zur Visualisierung des NMDA-Rezeptorstatus mittels der Positronen-Emissions-Tomographie (PET)

Der N-methyl-D-aspartat-Rezeptor (NMDA), als Vertreter ionotroper Glutamat-Rezeptoren, ist essentiell für physiologische Lern- und Gedächtnisvorgänge und eine krankhafte Überaktivierung wird als potentielle Ursache für eine Reihe von akuten und chronischen neurodegenerativen Erkrankungen angesehen. Hierbei sind für die akuten Erkrankungen vor allem der Schlaganfall und für die chronischen Erkrankungen Morbus Parkinson sowie die Alzheimer´sche Demenz zu nennen. Durch seine einzigartige spannungsabhängige Mg2+-Blockade und der Notwendigkeit der gleichzeitigen Anwesenheit der endogenen Liganden Glutamat und Glycin zur Rezeptoraktivierung, stellt dieser Rezeptorkomplex daher ein sehr interessantes molekulares Target dar. NMDA-Rezeptor-Antagonisten der Glycin-Bindungsstelle und der verschiedenen allosterischen Bindungsstellen könnten als Neuroprotektiva bei den verschiedenen Krankheiten eine symptomatische Verbesserung bewirken und zur Therapie eingesetzt werden. Eine visuelle Darstellung des Rezeptors im Rahmen von Vorsorgeuntersuchungen ist jedoch derzeit nicht möglich. Zur Visualisierung dieser Prozesse mittels der Positronen-Emissions-Tomographie (PET) wurden basierend auf einer Hydantoin-substituierten Indol-2-carbonsäure als Leitstruktur, im Rahmen dieser Arbeit Fluorethoxy- und Methoxy-substituierte Derivate dargestellt und in pharmazeutischen und radiopharmazeutischen Studien evaluiert. Dazu wurde die Affinität und Spezifität zum Rezeptor in einem [3H]MDL-105,519 Rezeptorbindungsassay und die Lipophilie als Parameter für die Hirngängigkeit ermittelt. Anhand dieser Resultate wurden geeignete Markierungsvorläufer synthetisiert, welche eine phenolische Hydroxylfunktion besitzen und eine radioaktive Markierung mit den sekundären Markierungsvorläufern 2-[18F]Fluorethyltosylat ([18F]FETos) und [11C]Methyliodid ([11C]CH3I) ermöglichen. Unter Verwendung von 4,6-Dichlor-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indol-2-carbonsäure wurde in einer Einstufenreaktion mit [18F]FETos die Zielverbindung 4,6-Dichlor-3-((3-(4-(2-[18F]fluorethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indol-2-carbonsäure in radiochemischen Ausbeuten von 6 % erhalten. Daher wurde eine alternative Markierung des Ethylester-geschützten Derivates 4,6-Dichlor-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indol-2-carbonsäureethylester in einer Zweistufensynthese mit [18F]FETos und [11C]CH3I untersucht. Unter Verwendung dieser Strategie wurden unter optimierten Bedingungen 4,6-Dichlor-3-((3-4-(2-[18F]fluorethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indol-2-carbonsäureethylester und 4,6-Dichlor-3-((3-(4-[11C]methoxy-phenyl)-2,4-dioxoimidazolidin-1-yl)-methyl)-indol-2-carbonsäureethylester in radiochemischen Ausbeuten von 27 – 38 % erhalten. Die anschließende Entfernung der Schutzgruppe führte unter Bildung von Neben- und Zersetzungsreaktionen zu 4,6-Dichlor-3-((3-(4-(2-[18F]fluorethoxy)-phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indol-2-carbonsäure und 4,6-Dichlor-3-((3-(4-[11C]methoxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indol-2-carbonsäure in radiochemischen Gesamtausbeuten von 5 – 7 %. Die Überprüfung des biochemischen Konzepts in vivo durch µ-PET-Studien und durch autoradiographische Experimente an Rattenhirnschnitten, deuten auf eine niedrige in vivo-Aktivität hin, welche sich auf eine nicht ausreichende Passage der Blut-Hirn-Schranke zurückführen lässt.

Le figure genitoriali nella famiglia ipermoderna e le loro conseguenze sul discorso di genere

In questo studio abbiamo voluto tentare un approccio multifunzionale per l’analisi della società moderna, più precisamente per analizzare la figura della donna e dell’uomo in questa epoca, figure che non potrebbero essere analizzate senza considerare le tematiche genitoriali e familiari che sono alla base della società stessa, italiana e non solo. Abbiamo voluto indagare sia la figura materna che quella paterna, prendendo spunto dalle opere di Massimo Recalcati e di John Bowlby che tanto hanno meditato per quanto riguarda il rapporto della madre e del padre con il proprio figlio. Ci è sembrato necessario partire dalla famiglia e dalle figure genitoriali poiché queste costituiscono le fondamenta, sin dai tempi antichi, di ogni società, e considerare come sono variate tali figure nell’epoca ipermoderna costituisce un punto essenziale per delineare alcuni punti fondamentali di quella che Zygmunt Baumann ha definito società liquida. La scienza medica ha insegnato che alla base della «cultura» (in senso antropologico), di ogni cultura, sta il tenace legame del figlio con la propria madre, in un rapporto di dipendenza biologicamente determinato dalla prolungata infanzia dell’essere umano, condizionandone l’intera esistenza e, in qualche modo, sottraendogli sempre il raggiungimento della piena maturità. Infatti bisogna considerare che l’intera esistenza di un uomo, di qualsiasi essere umano, è influenzata da ciò che egli vede e sente nei primi anni di vita (nei primi 3 anni di vita, secondo la scienza), pertanto il rapporto con la madre, il primo rapporto con la figura materna, è basilare per la vita futura dell’individuo. Una volta terminato il ruolo materno, ossia quando il ragazzo è pronto per entrare nella società, è il padre (o meglio, la figura paterna) ad accompagnarlo nel suo raggiungimento della virile maturità e a prenderlo per mano durante il periodo, cosiddetto, della castrazione (psicologica), ossia della piena maturità e del distacco dal “seno materno”. Il femminismo con i suoi movimenti degli anni ’70 ha portato ad una rottura, ad una vera e propria rivoluzione nel rapporto tra le parti. La donna ha acquisito una sempre maggiore consapevolezza portando non solo ad un nuovo e rinnovato tipo di femminilità, ma anche, dirimpetto, ad una differente tipologia di mascolinità, probabilmente meno consapevole e più debole, alimentando una sorta di sentimento ginecofobico che acuisce man mano che si va avanti, nonché un’assenza di dialogo tra i due universi, quello femminile e quello maschile, con una paura di fondo da parte di quest’ultimo.

Teaching the Millennial Generation in the Religious and Theological Studies Classroom

This essay provides an overview of the distinctive challenges presented to teaching and learning in religious and theological studies by the conditions and characteristics of “millennial” students. While the emerging literature on this generation is far from consistent, it is still instructive and important to engage, as students that are immersed in technology and social networking have different facilities and difficulties that educators would do well to carefully address and critically employ. Teachers in theological and religious studies are distinctly positioned to grapple with such conditions, particularly around the practices of identity formation, media literacy, and embodiment. Attention to the development of such practices engages key issues for both the millennial students and the religious and theological studies teacher: virtual reality, spiritual identity, globalization and violence, critical consumption and ethical creativity, focused and contemplative thinking, and intercultural and interpersonal respect.

Role of CYP27A1 in progesterone metabolism in vitro and in vivo

In the kidney, progesterone is inactivated to 20alpha-dihydro-progesterone (20alpha-DH-progesterone) to protect the mineralocorticoid receptor from progesterone excess. In an attempt to clone the enzyme with 20alpha-hydroxysteroid activity using expression cloning in CHOP cells and a human kidney expression library, serendipitously cDNA encoding CYP27A1 was isolated. Overexpression of CYP27A1 in CHOP cells decreased progesterone conversion to 20alpha-DH-progesterone in a dose-dependent manner, an effect enhanced by cotransfection with adrenodoxin and adrenodoxin reductase. Incubation of CHOP cells with 27-hydroxycholesterol, a product of CYP27A1, increased the ratio of progesterone/20alpha-DH-progesterone in a concentration-dependent manner, indicating that the effect of CYP27A1 overexpression was mediated by 27-hydroxycholesterol. In order to analyze whether these observations are relevant in vivo, progesterone and 20alpha-DH-progesterone were measured by GC-MS in 24-h urine of CYP27A1 gene knock out (ko) mice and their control wild type (wt) and heterozygote (hz) littermates. In CYP27A1 ko mice, urinary progesterone concentrations were decreased, 20alpha-DH-progesterone increased and the progesterone/20alpha-DH-progesterone ratio decreased threefold (p<0.001). Thus, CYP27A1 modulates progesterone concentrations. The underlying mechanism is inhibition of 20alpha-hydroxysteroid dehydrogenase by 27-hydroxycholesterol. Key words: Progesterone, sterol 27-hydroxylase, 27-hydroxycholesterol, 20a-steroid dehydrogenase, 20a-DH-progesterone.