Bioeffects of albumin-encapsulated microbubbles and real-time myocardial contrast echocardiography in an experimental canine model

Myocardial contrast echocardiography has been used for assessing myocardial perfusion. Some concerns regarding its safety still remain, mainly regarding the induction of microvascular alterations. We sought to determine the bioeffects of microbubbles and real-time myocardial contrast echocardiography (RTMCE) in a closed-chest canine model. Eighteen mongrel dogs were randomly assigned to two groups. Nine were submitted to continuous intravenous infusion of perfluorocarbon-exposed sonicated dextrose albumin (PESDA) plus continuous imaging using power pulse inversion RTMCE for 180 min, associated with manually deflagrated high-mechanical index impulses. The control group consisted of 3 dogs submitted to continuous imaging using RTMCE without PESDA, 3 dogs received PESDA alone, and 3 dogs were sham-operated. Hemodynamics and cardiac rhythm were monitored continuously. Histological analysis was performed on cardiac and pulmonary tissues. No hemodynamic changes or cardiac arrhythmias were observed in any group. Normal left ventricular ejection fraction and myocardial perfusion were maintained throughout the protocol. Frequency of mild and focal microhemorrhage areas in myocardial and pulmonary tissue was similar in PESDA plus RTMCE and control groups. The percentages of positive microscopical fields in the myocardium were 0.4 and 0.7% (P = NS) in the PESDA plus RTMCE and control groups, respectively, and in the lungs they were 2.1 and 1.1%, respectively (P = NS). In this canine model, myocardial perfusion imaging obtained with PESDA and RTMCE was safe, with no alteration in cardiac rhythm or left ventricular function. Mild and focal myocardial and pulmonary microhemorrhages were observed in both groups, and may be attributed to surgical tissue manipulation.

Meditationes sancti evangelii 27

Variantti A.

Doctrina de juris jurandi religione nonnullis aphorismis comprehensa

Invokaatio: Q.B.V.

De mensura et mensurato

Invokaatio: Praevia sacrosancta Triade!

Rosuvastatin prevents myocardial necrosis in an experimental model of acute myocardial infarction

Dyslipidemia is related to the progression of atherosclerosis and is an important risk factor for acute coronary syndromes. Our objective was to determine the effect of rosuvastatin on myocardial necrosis in an experimental model of acute myocardial infarction (AMI). Male Wistar rats (8-10 weeks old, 250-350 g) were subjected to definitive occlusion of the left anterior descending coronary artery to cause AMI. Animals were divided into 6 groups of 8 to 11 rats per group: G1, normocholesterolemic diet; G2, normocholesterolemic diet and rosuvastatin (1 mg·kg-1·day-1) 30 days after AMI; G3, normocholesterolemic diet and rosuvastatin (1 mg·kg-1·day-1) 30 days before and after AMI; G4, hypercholesterolemic diet; G5, hypercholesterolemic diet and rosuvastatin (1 mg·kg-1·day-1) 30 days after AMI; G6, hypercholesterolemic diet and rosuvastatin (1 mg·kg-1·day-1) 30 days before and after AMI. Left ventricular function was determined by echocardiography and percent infarct area by histology. Fractional shortening of the left ventricle was normal at baseline and decreased significantly after AMI (P < 0.05 in all groups), being lower in G4 and G5 than in the other groups. No significant difference in fractional shortening was observed between G6 and the groups on the normocholesterolemic diet. Percent infarct area was significantly higher in G4 than in G3. No significant differences were observed in infarct area among the other groups. We conclude that a hypercholesterolemic diet resulted in reduced cardiac function after AMI, which was reversed with rosuvastatin when started 30 days before AMI. A normocholesterolemic diet associated with rosuvastatin before and after AMI prevented myocardial necrosis when compared with the hypercholesterolemic condition.

De ortu et incrementis linguae latinae 2

Dedikaatio: Matthias Ingman.

Försök till en historisk beskrifning öfver den Kongl. Hof-rätten i Åbo 3

Arkit: 1 arkintunnukseton lehti, F4 G2. - S. [2] tyhjä.

De equo Troiano

Invokaatio: A.O.J.A!

De aëre discursus physiologicus, in thesi & antithesi adornatus

Dedikaatio: Christiernus Karplan, Matthias Iser, Bernhardus Ricardi, Nicolaus Alanus, Johannes Miltopaeus, Johannes Kanckel, Henricus Tålpo.

Miscellaneae quaestiones

Nimekettä edeltää hepreankielinen invokaatio.

De arte picem destillandi in Ostrobotnia

Invokaatio: Deo Duce.

Contra aeternitatem mundi

Invokaatio: Q.B.D.V.

Graduale (MS C.III.36, "Ilmajoen Graduale II")

A very small gradual and hymnary, for the most part copied in the last years of the sixteenth century or in the first quarter of the seventeenth. Assuming that Henricus Jacobi indeed signed his name in the sixteenth century (as Kurvinen reports), some of the manuscript was copied in that century: in lieu of a more accurate indicator the date of the manuscript appears to fall between 1589 and Mathias Benedicti's additions in 1635. The book was kept, perhaps even copied but certainly used, at Ilmajoki from the seventeenth century, and came from there to the University Library.

Magnus Erikssons stadslag et al. (MS F.ö.V.25)

A collection of laws prepared copied ca. 1591 by a Mathias Erici from Rauma, perhaps a judge or a teacher.

Qualidade da farinha de mandioca do grupo seca

Na Região Norte, a farinha de mandioca é produzida em pequenos estabelecimentos denominados de "Casas de Farinha", que apresentam problemas de adequação às exigências da legislação devido ao seu processamento e às precárias condições higiênico-sanitárias. Este trabalho teve como objetivo avaliar o padrão de qualidade da farinha de mandioca do grupo seca, subgrupo fina, tipo 1. Foram coletadas dez amostras de farinha de mandioca nos principais supermercados e feiras da cidade de Belém, PA, tendo sido realizadas análises físico-químicas, microbiológicas e pesquisa de sujidades. De acordo com a Portaria Nº 554 de 30.08.1995 da Secretaria da Agricultura, do Abastecimento e Reforma Agrária, das dez amostras de farinha de mandioca analisadas, em todas foram encontrados valores acima do padrão permitido para a acidez total, cujo valor máximo é de 3 meq. NaOH/100 g, e cinco amostras apresentaram-se abaixo da tolerância mínima exigida para o amido, que é de 75%. De acordo com a Resolução RDC nº 12 de 02.01.2001 da Agência Nacional de Vigilância Sanitária, todas as amostras de farinha de mandioca apresentaram-se dentro dos padrões aceitáveis de contaminantes microbiológicos. De acordo com a Resolução RDC nº 175 de 08.07.2003, das dez amostras de farinha de mandioca analisadas, foram encontradas oito fora dos padrões exigidos, por apresentarem sujidades.