Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B e antigen transgenic mice.

Helper T (Th) cells are classified as Th1 or Th2 cells by virtue of cytokine secretion and function as mediators of cellular or humoral immunity, respectively. Cytokines also regulate the differentiation of Th cells. For example, interleukin (IL)-12 promotes Th1 and suppresses Th2 cell development, suggesting that IL-12 may be useful therapeutically in Th2-mediated autoimmune and allergic disorders. Therefore, the effect of systemic IL-12 treatment on in vivo autoantibody synthesis in hepatitis B e antigen (HBeAg)-expressing transgenic mice, which is dependent on self-reactive Th2 cells, was examined. Low-dose IL-12 significantly inhibited autoantibody production by shifting the Th2-mediated response toward Th1 predominance. Additionally, previous studies suggest that a predominance of HBeAg-specific Th2-type cells may contribute to chronicity in hepatitis B virus infection. Therefore, IL-12 may also prove beneficial in modulating the HBeAg-specific Th response to favor viral clearance in chronic hepatitis B virus infection.

al- Juz al-awwal min Asmā al-mubhamah fī al-anbā al-muḥkamah / taṣnīf al-Imām al-Ḥāfiẓ Abī Bakr Aḥmad ibn ʻAlī ibn Thābit al-Khaṭīb al-Baghdādī : manuscript, [12--?]

Bound with ʻAlī ibn al-Ḥasan ibn ʻAsākir, Kitāb al-Arbaʻīn al-buldānīyah, and other hadith collections.

Concerto grosso for string orchestra, no. 12, B minor, op. 6, no. 12.

Mode of access: Internet.

Administration of farm programs by farmer committees. Hearings before a subcommittee, Eighty-fourth Congress, first and second sessions, on S. 544, a bill to amend section 8 (b) of the Soil Conservation and Domestic Allotment Act, as amended, to provide for administration of farm programs by democratically elected farmer committeemen. June 13-14, November 14-15, 1955; June 11-12, 1956.

Mode of access: Internet.

Nice wanton; date of this the earliest known edition, 1560 (B.M. pressmark C. 12, e. 20) ... reproduced in facsimile 1909.

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Carter, Masson, and Richard nominations : hearing before the Committee on Energy and Natural Resources, United States Senate, Ninety-seventh Congress, second session, on the nominations of John B. Carter, Jr., to be a member of the board of directors, United States Synthetic Fuels Corporation; Milton M. Masson, Jr., to be a member of the board of directors, United States Synthetic Fuels Corporation; and Oliver G. Richard III, to be a member, Federal Energy Regulatory Commission, August 12, 1982.

"Publication no. 97-91."