Interview with Anna Heriot Dixon

Anna Dixon, in her July 1974 interview with Ann Yarborough, described the lifestyle and traditions she experienced during her years as a student at what is now Winthrop University (then Winthrop Normal and Industrial College). Dixon graduated in 1917 and covered topics such as being campused, the train station, education for women, uniforms, curriculum, and the training school. She also touched on what might get a girl expelled and how the students were graded. This interview was conducted for inclusion into the Louise Pettus Archives and Special Collections Oral History Program.

Impact of FLT3 Internal Tandem Duplication on the Outcome of Related and Unrelated Hematopoietic Transplantation for Adult Acute Myeloid Leukemia in First Remission: A Retrospective Analysis

Purpose Patients with acute myeloid leukemia (AML) and FLT3/internal tandem duplication (FLT3/ITD) have poor prognosis if treated with chemotherapy only. Whether this alteration also affects outcome after allogeneic hematopoietic stem-cell transplantation (HSCT) remains uncertain. Patients and Methods We analyzed 206 patients who underwent HLA-identical sibling and matched unrelated HSCTs reported to the European Group for Blood and Marrow Transplantation with a diagnosis of AML with normal cytogenetics and data on FLT3/ITD (present: n = 120, 58%; absent: n = 86, 42%). Transplantations were performed in first complete remission (CR) after myeloablative conditioning. Results Compared with FLT3/ITD-negative patients, FLT3/ITD-positive patients had higher median leukocyte count at diagnosis (59 v 21 x 10(9)/L; P < .001) and shorter interval from CR to transplantation (87 v 99 days; P = .04). Other characteristics were similar in the two groups. At 2 years, relapse incidence (RI; +/- standard deviation) was higher (30% +/- 5% v 16% +/- 5%; P = .006) and leukemia-free survival (LFS) lower (58% +/- 5% v 71% +/- 6%; P = .04) in FLT3/ITD-positive compared with FLT3/ITD-negative patients. In multivariate analyses, FLT3/ITD led to increased RI (hazard ratio [HR], 3.4; 95% CI, 1.46 to 7.94; P = .005), as did older age, female sex, shorter interval between CR and transplantation, and higher number of chemotherapy courses before achieving CR. FLT3/ITD positivity was associated with decreased LFS (HR, 0.37; 95% CI, 0.19 to 0.73; P = .002), along with older age and higher number of chemotherapy courses before achieving CR. Conclusion FLT3/ITD adversely affected the outcome of HSCT in the same direction it does after chemotherapy; despite this, more than half of the patients harboring this mutation who received transplants were alive and leukemia free at 2 years. To further improve the results, use of FLT3 inhibitors before or after HSCT deserves investigation.

L'adulterio come strumento sociale: confronto tra Anna Karenina e Lady Chatterley

Lo scopo di questo lavoro è confrontare due opere, Anna Karenina di Lev Tolstoj e L’amante di Lady Chatterley di David Herbert Lawrence e dimostrare che essi non hanno in comune solo il tema dell’adulterio, ma anche e soprattutto l’averlo inteso come strumento di ribellione sociale. In Tolstoj troviamo l’adulterio censurato nel corso della narrazione, poiché esso viene condannato sia dalla società che dall’autore stesso, che aveva come intento dare una lezione morale. Lawrence invece esalta e descrive l’adulterio, poiché nel suo caso diventa lo strumento di scoperta dell’amore vero e di ritorno al primitivismo a dispetto della civiltà industrializzata. Quindi, pur appartenendo a due epoche diverse e a due società con differenti visioni circa matrimonio e famiglia, le due eroine sono similari per il coraggio che dimostrano nell’andare contro le rispettive società.

Anna, sette anni al fronte. Analisi e proposta di sottotitolaggio del film documentario Anna, sem' let na linii fronta

The aim of the present work was to make more accessible a documentary film that focuses on the life and work of the Russian journalist killed in Moscow in 2006: Anna Politkovskaja. The film, entitled “Anna, seven years at the frontline” is a collage of several video-interviews with Politkovskaja’s friends and colleagues, in which they talk about who she was, what was her job about and how she tried to make the public aware about the Chechen wars. Working on this translation gave me a unique opportunity to deepen one of the most controversial issues in the recent history of Russia and to create a useful final product for those who have a particular interest in this topic but do not have the necessary linguistic competence to understand this documentary film.

Novel mutations consolidate KCTD7 as a progressive myoclonus epilepsy gene

The progressive myoclonus epilepsies (PMEs) comprise a group of clinically and genetically heterogeneous disorders characterised by myoclonus, epilepsy, and neurological deterioration. This study aimed to identify the underlying gene(s) in childhood onset PME patients with unknown molecular genetic background.