Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population.

PURPOSE:

To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population.

DESIGN:

Family-based cohort study.

PARTICIPANTS:

Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships.

METHODS:

Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glaucoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP.

MAIN OUTCOME MEASURES:

Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR.

RESULTS:

We estimated the heritability to be 0.29 (95% confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95% CI, 0.35-0.76) for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19%) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004).

CONCLUSIONS:

In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.

Physical rehabilitation interventions for adult patients during critical illness: an overview of systematic reviews

Background Physical rehabilitation interventions aim to ameliorate the effects of critical illness-associated muscle dysfunction in survivors. We conducted an overview of systematic reviews (SR) evaluating the effect of these interventions across the continuum of recovery.

Methods Six electronic databases (Cochrane Library, CENTRAL, DARE, Medline, Embase, and Cinahl) were searched. Two review authors independently screened articles for eligibility and conducted data extraction and quality appraisal. Reporting quality was assessed and the Grading of Recommendations Assessment, Development and Evaluation approach applied to summarise overall quality of evidence.

Results Five eligible SR were included in this overview, of which three included meta-analyses. Reporting quality of the reviews was judged as medium to high. Two reviews reported moderate-to-high quality evidence of the beneficial effects of physical therapy commencing during intensive care unit (ICU) admission in improving critical illness polyneuropathy/myopathy, quality of life, mortality and healthcare utilisation. These interventions included early mobilisation, cycle ergometry and electrical muscle stimulation. Two reviews reported very low to low quality evidence of the beneficial effects of electrical muscle stimulation delivered in the ICU for improving muscle strength, muscle structure and critical illness polyneuropathy/myopathy. One review reported that due to a lack of good quality randomised controlled trials and inconsistency in measuring outcomes, there was insufficient evidence to support beneficial effects from physical rehabilitation delivered post-ICU discharge.

Conclusions Patients derive short-term benefits from physical rehabilitation delivered during ICU admission. Further robust trials of electrical muscle stimulation in the ICU and rehabilitation delivered following ICU discharge are needed to determine the long-term impact on patient care. This overview provides recommendations for design of future interventional trials and SR.

Psalterium ad usum ecclesiae Sarisburiensis.

F. 1 Calendrier de Salisbury, avec addition d'obits de Jean Cokayn, justicier du roi (22 juin 1429) et de sa femme Ide (1er juin 1426). F. 23 Psautier, cantiques, litanies de Salisbury. F. 207 Office des morts.

Compte de la croisade prêchée dans le diocèse de Toulouse contre les « Infidelles » durant les années 1517 et 1518, et pièces y relatives.

Contient : 1 « Copie d'unes lectres patentes du roy nostre sire, données à Amboise le XVIme jour de decembre 1516, par lesquelles appert led. Sr avoir commis et deputé maistre Josse de La Garde, docteur en theologie, vicaire general de l'eglise cathedral de Thouloze, commissaire touchant le faict de la croisade aud. diocèse de Thouloze ». Acte de FRANÇOIS Ier, en latin ; 2 « Autre copie des instructions envoiées par le roy à messire Josse de La Garde... commis et depputé par led. Sr et par Reverend père en Dieu, monsieur l'evesque de Tricary, ambassadeur devers icelluy Sr pour nostre saint père le pape, touchant le fait et execution de la bulle octroiée et decernée par lui du jubillé et croisade en ce royaume, durant deux années finies 1517 et 1518, desquelles instructions cy rendues la teneur s'ensuit... » ; 3 « Autre copie des memoires signéez (sic) de la main du roy, envoyez aud. commissaire pour le fait de lad. croisade, dont la teneur s'ensuit... » ; 4 « Autre copie des lectres de très reverend père ANTHOINE BOHIER, cardinal de Bourges, et de reverend père en Dieu LOYS DE CANOSSA, evesque de Bayeulx et de Tricary, commissaire en ceste partie, depputez par nostre sainct pere le pappe, par lesquelles usant du pouvoir à eulx sur ce donné, ilz ont permys et octroyé aux prescheurs de la croisade et jubillé le quinton de deniers et oblations qui y seront donnez par ceulx qui devotement y donneront de leurs biens, desquelles lectres la teneur s'ensuit... ». Rouen 16 decembre et Bayeux 20 décembre 1517. En latin ; 5-7 « Autre copie de troys lectres missives du roy » FRANÇOIS Ier, « adressées à Jehan Cluchern (sic) receveur de lad. croisade, à messire Raymond Raffin, contrerolleur, et à messire Josse de La Garde, vicaire general, commissaire subdelegué, par lesquelles le roy nostre dict seigneur leur mande vacquer et entendre chascun en son regard au fait et execution » de « sa commission, desquelles lectres missives subsecutives les teneurs s'ensuivent... ». Amboise, 17 décembre 1516 ; 8 « Compte de maistre Jehan Clucher, notaire royal, bourgeoys de Thouloze, commis par le roy nostre sire et ses lectres missives données à Amboise, le XVIIe jour de decembre, l'an 1516, à faire la recepte ou diocèse de Thouloze, des deniers provenans et yssans du jubillé et pardon general de plainière remission donné et concedé par nostre sainct père le pape » Leon X, « durant deux ans à tous vrays chrestiens de ce royaume, pays, terres et seigneuries, de l'obeissance et subjection du roy nostredict seigneur, lesquelz donneroient et eslargiroient de leurs biens pour employer à faire la guerre aux infidelles et conquerir la terre saincte et empire de Grèce, detenuz et usurpez par lesdicts infidelles... de la recepte et despense faictes par ledict maistre Jehan Clucher, receveur, à cause des deniers yssuz et provenuz aud. diocèse de Thouloze, tant pour les confessionnaulx que pour les deniers du jubillé prins et trouvez ès troncqs estans tant en lad. ville de Thouloze que dehors, speciffiez et declairez en ung cayer de papier signé et arresté de la main dudict messire Josse de La Garde, commissaire, et dudict messire Raymond Raffin contreroolleur, compte rendu à court par Guillaume Voisin, procureur dudict maistre Jehan Clucher, fondé par lectres de procuracion... comme il s'ensuit... ». A la fin on lit les signatures : « P. archiepiscopus Aquensis,... d'Albyac,... Riveroy »

« Seconde navigation faicte par le commandement et vouloir du très chrestien roy Françoys Premier de ce nom, au parachevement de la descouverture des terres occidantalles estantes soubz le climat et paralelles des terres et royaulme dud. Sr et par luy precedantement jà commancées à faire descouvrir, icelle navigation faicte par JACQUES CARTIER, natif de Sainct Malo de l'Isle en Bretaigne, pillote dud. Sr, en l'an mil cinq cens trante six ».

Contient : Le récit de cette seconde navigation commence par un discours adressé au roi François Ier ; Après ce discours, le récit s'ouvre (fol. 3) par : « Le dimanche jour et feste de la Pandecoste XVIme jour de may aud. an mil cinq cens trente cinq, du commandement du cappitaine et bon voulloir de tous, chascun se confessa et ressumes tous ensemblement nostre createur en l'eglise cathedral dudict Sainct-Malo... ». Derniers mots : « ... le priant, faisant fin à nostre navigation, nous donner sa grâce et paradis à la fin. Amen »

« Seconde navigation faicte par le commandement et voulloir du très chrestien roy François, premier de ce nom, au parachèvement de la descouverte des Terres occidentalles estans soubz le climat et parallelles des terres et royaulme dudict seigneur, et par luy precedantement ja commancées à faire descouvrir, icelle navigation faicte par JACQUES CARTIER, natif de Sainct Malo de l'Isle en Bretaigne, pillote dud. Sr, en l'an mil cinq cens trente six ».

Contient : A la suite est un choix de mots intitulé : « Ensuict le langaige des pays et royaulmes de Hochelaga et Canada, autrement dicte la Nouvelle France »

Girls Volleyball Team

Pictured here from left to right: Back Row - Mike Rohatynski (Coach?), Ivi Ernesaks, Maureen Halpenny, Helen, Henderson, Pat Hueston (Coach). Front Row - Enid Salisbury, Jane Hemphell, Beth Gayman. Missing - Pat Johnson, Debbie MacMillan, and Jean Milburn.

Local Postcards, 1996, n.d.

6 of the postcards are sketches by Norbert Collins, these include: St. George’s Anglican Church, the museum, St. Paul United Church, Ridley College clock tower, St. Catherine’s Cathedral and the Willam Hamilton Merritt monument (all of St. Catharines). The 7th postcard is a picture of the St. Catharines Craft Guild Shop in Port Dalhousie (artist unknown). Norbert J. Collins is a Canadian artist.

Proposal for Construction of Brock’s Monument, Queenston, newspaper fragment, 1824

Brock’s Monument is owned by Parks Canada and maintained by the Niagara Parks Commission in collaboration with the Friends of Fort George and Niagara National Historic Sites. It is located in Queenston Heights Park atop the Niagara Escarpment. On March 14, 1815, Parliament passed an act to erect a monument to the memory of General Isaac Brock. A design by engineer Francis Hall was selected. He envisioned a 135 ft. tall Tuscan column, made out of stone with a winding staircase inside. By the spring of 1824, work had begun on the monument. In June of that year, the cornerstone was laid and William Lyon Mackenzie was in attendance at the ceremony. It was on October 13th, 1824 (the anniversary of Brock’s death) that 6000 people traveled to Queenston to inter the remains of Brock and Lieutenant-Colonel Macdonell. This was the second burial for both. After 3 years the tower had reached 135 feet, but there was no inscription at the base, the fence around the observation deck had not been installed and there was no statue of Brock. Hall submitted a plan to finish the statue, but he was turned down and a simple ornament was placed where the Brock statue should have been. A massive blast of gunpowder destroyed the monument in 1840. It is alleged that an American sympathizer with the Upper Canada Rebellion set off the blast. Brock and Macdonell’s bodies were reburied in the Hamilton Family Cemetery in Queenston. The present monument was rebuilt in 1853. William Thomas (designer of St. Michael’s Cathedral in Toronto) was the architect. Brock and Macdonell were once again laid to rest in separate vaults at the statue. In 1968, Brock’s Monument was declared a national historical site. In 2005, it was closed to the public due to safety concerns, but it reopened in 2010. Source: http://www.thecanadianencyclopedia.com/articles/brocks-monument-queenston-heights

Niagara churches collection, 1937, 1968-1994

This collection contains 7 church programs and brochures, ranging in date from 1937 to 1994. There are programs for church services at Knox Presbyterian Church, St. Catharines (May 9, 1937); St. Catherine of Alexandria Cathedral, St. Catharines (July 28, 1968) ; Memorial United Church, Ridgeway (October 15, 1972); Salem Chapel, British Methodist Episcopal Church, St. Catharines (November 30, 1986); and Ridley College Memorial Chapel, St. Catharines (December 3 & 4, 1994). There is also a brochure of activities offered at St. Paul Street United Church, St. Catharines (1986), and a development fund appeal brochure for the Cathedral of St. Catherine, St. Catharines (1985).

Photograph - Owls Bicycle Club, 1889

A photograph of the Owls Bicycle Club in the year 1889. The men are in the rear of the Watson memorial with St. Joseph's convent/orphanage and St. Catharines Cathedral in the background. There are 21 men on bicycle including Stanley G. Smith (second row, fourth from the left).

Ann Eliza Hepburne Rooth fonds, 1837-1897

Ann Eliza Hepburne was born in Chippawa, Ontario, in 1821, to William Hepburne and Susan Shannon. In 1842, she married William Anthony Rooth in St. James Cathedral in Toronto. They continued to live in different parts of the Niagara region, including Drummondville, Welland and Port Colborne. William was the editor and proprietor of the Drummondville Reporter, as well as an accountant and insurance agent, and later worked for the Customs Service in Port Colborne. He died in 1878, and Eliza in 1899. Both are buried in Drummond Hill Cemetery in Niagara Falls, Ontario.

Father Sean O'Sullivan Ordination Invitation

An invitation to the ordination of Father Sean O'Sullivan, October 1981. The ordination took place at St. Michael's Cathedral in Toronto, 3 October 1981. His first Mass of Thanksgiving took place the next day at St. John's Church in Toronto.

A text-book of mineralogy : with an extended treatise on crystallography and physical mineralogy

UANL