治癌专用离子同步加速器的物理设计

放射治疗肿瘤是利用各种放射线所携带的能量及其生物效应治疗肿瘤的一种方法。论文简要介绍了癌症的危害性和目前基本的治疗方法，回顾了国际上放射治疗肿瘤的发展历程和近年来的新动向，说明了国内放射治疗肿瘤工作的现状以及近几年的发展。为了促进国内癌症治疗的进一步发展，研究设计了国内第一台离子治癌专用装置。它由一台注入器（回旋加速器）、一台主加速器 (同步加速器)和若干治疗终端组成，能够把质子束加速到250MeV或者把碳离子束加速到430MeV/u，用于治疗人体内任意深度的肿瘤。 论文的重点是同步加速器的磁聚焦结构、注入和引出系统的设计。 商业化运行的治癌专用离子同步加速器通常采用紧凑性结构，要求操作简单，运行稳定可靠。论文根据治癌专用离子同步加速器的这些要求，研究设计了磁聚焦结构。 由于直线加速器的高流强特性，目前已有的国外离子治癌专用装置，几乎全部使用直线加速器作为同步加速器的注入器，同时采用多圈注入方式。考虑到直线加速器高的投入，借鉴大科学工程CSR束流累积的经验，论文以回旋加速器为注入器，采用剥离注入模式设计了治癌同步加速器的注入系统。另外，还对剥离注入期间离子束发射度、动量分散等参数的变化进行了较为详细的研究。 离子束治癌一般要求小剂量连续照射（1-10s），因此治癌专用离子同步加速器均采用三阶共振引出方式。论文详细阐述了三阶共振引出的基本理论与设计方法，在此基础上设计了离子束引出系统。通过磁聚焦结构、注入及引出设计的整体优化，提出了磁铁好场区和真空室孔径的参数。 最后，论文对慢引出的两种激发方式进行了理论探讨，并对纵向激发元件——磁电感应器（Betatron-core）的电流、阻抗和电压等参数的变化，以及电源纹波对引出束均匀性的影响进行了较为详细的分析计算

重离子同步加速器SIS中的束团纵向稳定性理论、测量和模拟

本论文中的工作是在德国重离子研究中心（GSI）和中国科学院近代物理研究所的联合培养计划下完成的。论文以GS工的重离子同步加速器SIS为主要研究对象，就其强流运行及为GSI最近批准的新项目而升级的纵向动力学方面进行了研究和探讨。该项工作对于在建的大科学工程兰州重离子储存环HIRFL-CSR有借鉴意义。在GSI的新项目国际重离子、反质子加速器科学研究装置的蓝图中，现有的重离子同步加速器S工S将作为前级提升束流的强度和能量。束团的纵向稳定性是保证可靠的强流运行所必须回答的问题，包括以下内容，在本文中分别进行了探索和解答：纵向的重离子加速器环境阻抗模型；在可能的阻抗条件下束流线性稳定性；在阻尼及不稳定性效应下束流相空间分布的演化行为和结果（发射度增长、粒子丢失等）及其内在机制；对不稳定性和束流相空间稀释效应进行控制的可能性。不同流强下束流纵向相空间测量，这是本论文工作的一个重要基础。自洽的Vlasov束团模型（任意外场加空间电荷效应下的束流匹配）和实际运行中的非理想捕获过程（有限的高频电压上升时间，对应不同的绝热系数），作为任何束团运行和稳定性研究的前提分别在论文中得到了厘清。解析方面的工作包括定态和微扰理论，即将线性Vlasov方程应用于束团，并在适当的近似下得到简洁的解析方程。经过重新推导，得到了修正的Sachrer积分方程，使之在强空间电荷效应下的仍然适用，由此得到了线性稳定图。编写调试成功了PIC（particle-in-cell）算法的模拟程序，和线性理论相互校验，并与己得到的实验结果进行了对比，对实际运行中复杂过程进行了模拟，并研究了不稳定性发展后期非线性阶段。线性理论，模拟和实验结果有很好的一致性。在SIS实验中观察到一种流强相关的束团相干模式演化现象，该现象揭示出束团中朗道阻尼条件，这与束团稳定性密切相关。对空间电荷抑制朗道阻尼效应及发射度增长进行了细致研究。提出用快反馈装置控制相空间稀释的思路。线性理论和模拟的结果都预言，在阻性阻抗和空间电荷阻抗存在下，藕合束不稳定性是515多束团强流运行的潜在威胁。阻性阻抗来自管壁及加速器部件的有效导电性或特殊共振结构，或直接来自频率偏置的高频腔。阻抗补偿或特殊的束团操作可以用来控制桃合束不稳定性。

Facile preparation of macroscopic soft colloidal crystals with fiber symmetry

A facile, efficient way to fabricate macroscopic soft colloidal crystals with fiber symmetry by drying a latex dispersion in a tube is presented. A transparent, stable colloidal crystal was obtained from a 25 wt % latex dispersion by complete water evaporation for 4 days. The centimeter-long sample was investigated by means of synchrotron small-angle X-ray diffraction (SAXD). Analysis of a large number of distinct Bragg peaks reveals that uniaxially oriented colloidal crystals with face-centered cubic lattice structure were formed.

In Situ Observation of Tensile Deformation Processes of Soft Colloidal Crystalline Latex Fibers

The deformation mechanism or styrene/n-butyl acrylate copolymer latex films with fiber symmetric crystalline structure subjected to uniaxial stretching was studied using synchrotron small-angle X-ray scattering technique. The fibers were drawn at angles or 0, 35, and 55 degrees with respect to the Fiber axis. In all cases, the microscopic deformation within the crystallites was Found to deviate from affine deformation behavior with respect to the macroscopic deformation ratio. Moreover, the extent of this deviation is different in the three cases. This peculiar behavior can be attributed to the relative orientation of the (111) plane of the crystals, the plane of densest packing, with respect to the stretching direction in each case. When the stretching direction coincides with the crystallographic (111) plane, which is the case for stretching directions of 0 and 55 degrees with respect to the fiber axis, the microscopic deformation deviates less from affine behavior than when the stretching direction is arbitrarily oriented with respect to the crystallographic (111) plan.

Crystallization behaviors of n-nonadecane in confined space: Observation of metastable phase induced by surface freezing

Crystallization and phase transition behaviors of n-nonadecane in microcapsules with a diameter of about 5 mu m were studied with the combination of differential scanning calorimetry ( DSC) and synchrotron radiation X-ray diffraction ( XRD). As evident from the DSC measurement, a surface freezing monolayer, which is formed in the microcapsules before the bulk crystallization, induces a novel metastable rotator phase ( RII), which has not been reported anywhere else. We argue that the existence of the surface freezing monolayer decreases the nucleating potential barrier of the RII phase and induces its appearance, while the lower free energy in the confined geometry turns the transient RII phase to a " long- lived" metastable phase.

Investigation on isothermal and non-isothermal crystallization kinetics of poly (epsilon-caprolactone)

The crystallization kinetics and the development of lamellar structure during the isothermal crystallization of poly (epsilon-caprolactone) (PCL) were investigated by means of differential scanning calorimetry (DSC) and real-time synchrotron small angle X-ray scattering (SR-SAXS) techniques, respectively. The Avrami analysis was performed to obtain the kinetics parameters. The value of Avrami index, n, is about 3, demonstrating a three-dimensional spherulitic growth on heterogeneous nuclei in the process of isothermal crystallization. The activation energy and the surface free energy of chain folding for isothermal crystallization were determined according to the Arrhenius equation and Hoffman-Lauritzen theory, respectively. In the process of nonisothermal crystallization of PCL, the value of Avrami index, n, is about 4, which demonstrates a three-dimensional spherulitic growth on homogeneous nuclei. In addition, lamellar parameters were obtained from the analysis of SR-SAXS data.

Recent progress in the studies of endohedral metallofullerenes

This overview presents the recent progress in the area of endohedral metallofullerenes in the past several years. The important results have been summarized as follows: (1) Many metals including Group 3 metals, most of the lanthanide series elements, and Group 2 metals have been encapsulated into a fullerene cage to form mono-, di-, and trimetallofullerenes by using the arc-evaporation technique. (2) Some endohedral metallofullerenes such as Group 3 metals, most of the lanthanide series elements, Group 2 metals, and some of their isomers have been successfully isolated and purified by a two-step or several-step HPLC technique. By using high-temperature and high-pressure extraction with pyridine, Ln@C-80, Ln@C-82, and Ln2@C-80 for most rare-earth metals have been selectively extracted in high yield (about 1% of the saw soot) from fullerenes and other size metallofullerenes. (3) The endohedral nature of metallofullerenes such as Y@C-82, Sc2@C-84, and Sc@C-82 has been finally confirmed by synchrotron X-ray powder diffraction. The symmetries and the structures of metallofullerenes such as Ca@C-82(III), La-2@C-80(I-h), Sc-2@C-84(D-2d), and Sc-2@C-84(C-s) have been confirmed by NMR measurements. (Lb) The information on the electronic structures and properties of endohedral metallofullerenes has been obtained by various spectrometric means Such as EPR, W-vis-MR, XPS, CV. It is generally accepted that three-electron transfer is favorable when M = Y, La, Ce, Pr, Nd, Gd, Tb, Dy, Ho, Er, Lu but Sc, Eu, Sm, Yb, Tm, Ca, Sr, Ba prefer to donate two electrons to the fullerene cages. (5) Several chemical reactions of endohedral metallofullerenes have been reported in which reagents are disilacyclopropane, digermacyclopropane, diphenyldiazomethane, and trifluoroacetic acid. (6) Mass spectrometry provided the crucial evidence that led to the discovery of metallofullerenes in 1985 and has always played a key role in their identification and characterization, Ion-mobility measurements of gas-phase ions have obtained the information of structures and the formation mechanism of endohedral metallofullerenes. till Theoretical calculations on the endohedral metallofullerenes have made an important contribution to the studies on the symmetry of the cage, the position of metal atom(s) inside the cage, the number of electronic transfer between metal atom(s) and fullerene cage, etc. (C) 2000 Elsevier Science S.A. All rights reserved.

Copper phthalocyanine on InSb(111)A?interface bonding, growth mode and energy band alignment

Copper phthalocyanine on InSb(111)A?interface bonding, growth mode and energy band alignment, D.A. Evans, H.J. Steiner, S. Evans, R. Middleton, T.S. Jones, S. Park, T.U. Kampen, D.R.T. Zahn, G. Cabailh and I.T. McGovern, J. Phys.: Condens. Matter, 15, S2729?S2740, (2003)

Determination of the optical band-gap energy of cubic and hexagonal boron nitride using luminescence excitation spectroscopy

Sponsorship: EPSRC, STFC

New instrumentation for micro-imaging X-ray absorption spectroscopy using optical detection methods

Poolton, Nigel; Towlson, B.M.; Hamilton, B.; Evans, D.A., (2006) 'New instrumentation for micro-imaging X-ray absorption spectroscopy using optical detection methods', Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 246(2) pp.445-451 RAE2008

A fully integrated multi-channel detector for electron spectroscopy

Langstaff, David; Bushell, A.; Chase, T.; Evans, D.A., (2005) 'A fully integrated multi-channel detector for electron spectroscopy', Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 238 pp.219-223 RAE2008 Synchrotron Radiation in Materials Science ? Proceedings of the 4th Conference on Synchrotron Radiation in Materials Science 4th Conference on Synchrotron Radiation in Materials Science

Experimental and Modelling Studies of the Thermodynamics and Kinetics of Phase and Structural Transformations in a Gamma TiAl-based Alloy

This work combines microscopy, synchrotron radiation X-ray diffraction, differential scanning calorimetry and thermodynamic calculations in the characterisation of phase transformation behaviour of a Ti–46Al–1.9Cr–3Nb alloy upon continuous heating at constant rates. It has been found that the Ti–46Al–1.9Cr–3Nb alloy after being forged at 1200 °C without further treatment has a duplex microstructure consisting of fine equiaxed and lamellar ? grains with a small amount of a2 plates and particles and about 1 wt.% B2 phase. Differential scanning calorimetry revealed reproducibly several thermal effects upon heating of the as-forged alloy. These thermal effects are related to the equilibration and homogenisation of the sample, change of phase ratios between a2, ? and B2 phases in particular the increase of B2 in respect to a2 and ?, and the following five phase transformations: a2 + ? + B2 a + ? + B2, a + ? + B2 a + ?, ? + a a, a a + ß, a + ß a + ß + L. The observation of these transformations by differential scanning calorimetry is largely in agreement with literature phase diagrams and thermodynamic calculations, though care is needed to consider the different alloy compositions. Kinetics of the ? + a a phase transformation in the Ti–46Al–1.9Cr–3Nb alloy has been quantitatively derived from the calorimetry data, giving phase compositions at any point during the transformation upon continuous heating.

High-pressure deformation mechanism in scolecite: A combined computational-experimental study

Pressure-induced structural modifications in scolecite were studied by means of in situ synchrotron X-ray powder diffraction and density functional computations. The experimental cell parameters were refined up to 8.5 GPa. Discontinuities in the slope of the unit-cell parameters vs. pressure dependence were observed; as a consequence, an increase in the slope of the linear pressure-volume dependence is observed at about 6 GPa, suggesting an enhanced compressibility at higher pressures. Weakening and broadening of the diffraction peaks reveals increasing structural disorder with pressure, preventing refinement of the lattice parameters above 8.5 GPa. Diffraction patterns collected during decompression show that the disorder is irreversible. Atomic coordinates within unit cells of different dimensions were determined by means of Car-Parrinello simulations. The discontinuous rise in compressibility at about 6 GPa is reproduced by the computation, allowing us to attribute it to re-organization of the hydrogen bonding network, with the formation of water dimers. Moreover we found that, with increasing pressure, the tetrahedral chains parallel to c rotate along their elongation axis and display an increasing twisting along a direction perpendicular to c. At the same time, we observed the compression of the channels. We discuss the modification of the Ca polyhedra under pressure, and the increase in coordination number (from 4 to 5) of one of the two Al atoms, resulting from the approach of a water molecule. We speculate that this last transformation triggers the irreversible disordering of the system.

Negative photoion spectroscopy of freon molecules in the vicinity of the Cl 2p edge

Polar photodissociation of CFnCl4-n (n=0-2) has been studied using synchrotron radiation within the energy range 195-217 eV. The first observations of negative photoion fragments from these molecules after core excitation are reported. In addition to observing a number of previously known resonances two additional resonant states, just above the Cl 2p ionization limit, are observed and play an important role in the polar photodissociation process. The difficulties in identifying these above threshold spin-split features using negative photoion spectroscopy are discussed.