Age hardening of a sintered Al-Cu-Mg-Si-(Sn) alloy

The age hardening response of a sintered Al-3.8 wt% Cu-1.0 wt% Mg-0.70 wt% Si alloy with and without 0.1 wt% Sn was investigated. The sequence of precipitation was characterised using transmission electron microscopy. The ageing response of the sintered Al-Cu-Mg-Si-(Sn) alloy is similar to that of cognate wrought 2xxx series alloys. Peak hardness was associated with a fine, uniform dispersion of lath shaped precipitates, believed to be either the betaor Q phase, oriented along < 010 >. directions and theta' plates lying on {001}(alpha). planes. Natural ageing also resulted in comparable behaviour to that observed in wrought alloys. Porosity in the powder metallurgy alloys did not significantly affect the kinetics of precipitation during artificial ageing. Trace levels of tin, used to aid sintering, slightly reduced the hardening response of the alloy. However, this was compensated for by significant improvements in density and hardness. (c) 2005 Elsevier B.V. All rights reserved.

Crystallization behavior of (Cu60Zr30Ti10)(99)Sn-1 bulk metallic glass

The crystallization behavior and crystallization kinetics Of (CU60Zr30Ti10)(99)Sn-1 bulk metallic glass was studied by X-ray diffractometry and differential scanning calorimetry. It was found that a two-stage crystallization took place during continuous heating of the bulk metallic glass. Both the glass transition temperature T-g and the crystallization peak temperatures T-p displayed a strong dependence on the heating rate. The activation energy was determined by the Kissinger analysis method. In the first-stage of the crystallization, the transformation of the bulk metallic glass to the phase one occurred with an activation energy of 386 kJ/mol; in the second-stage, the formation of the phase two took place at an activation energy of 381 kJ/mol.

Microstructure control in Sn-0.7mass%Cu alloys

Soldering alloys based oft the Sn-Cu alloy system are amongst the most favourable lead-free alternatives due to a range of attractive properties. Trace additions of Ni have been found to significantly improve the soldering characteristics of these alloys (reduced bridging etc.). This paper examines the mechanisms underlying the improvement in soldering properties of Sn-0.7 mass%Cu eutectic alloys modified with concentrations of Ni ranging front 0 to 1000 ppm. The alloys were investigated by thermal analysis during solidification, as well as optical/SEM microanalyses of fully solidified samples anti samples quenched during solidification. It is concluded that Ni additions dramatically alter the nucleation patterns and solidification behaviour of the Sn-Cu6Sn5 eutectic anti that these changes are related to the superior soldering characteristics of the Ni-modified Sn-0.7 mass%Cu alloys.

A rheological assessment of the effect of trace level Ni additions on the solidification of Sn-0.7Cu

The influence of trace level Ni additions on the eutectic solidification mode of Sn-0.7Cu has been studied using continuous torque experiments during solidification. The solid fraction at which resistance to paddle rotation at the thermal centre of the sample occurs is related to the spatial distribution of solid during solidification. The results indicate that a transition in solidification mode occurs in the range 0-300 ppm Ni. Growth occurs antiparallel to heat flow from near the mould walls in the Ni-free alloy, while equiaxed growth from distributed centres dominates in alloys containing at least 300 ppm Ni. (c) 2006 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

O Balanced Scored como ferramenta de gestão estratégica na Clínica Oftalmológica Dr. Miguel Sousa Neves, Lda.

A sociedade está cada vez mais complexa, sendo notória a preocupação por parte das organizações no que respeita à qualidade dos serviços prestados. Tal como nas outras atividades, a atenção às mais variadas alterações internas e externas por parte das organizações que prestam cuidados de saúde deve ser uma constante, garantindo assim uma rápida e eficaz resposta aos novos desafios. Neste contexto, as organizações de saúde vêem-se obrigadas a criar e utilizar modelos de gestão mais direcionados aos seus objetivos concretos de forma a atingir os fins que visionaram sendo o Balanced Scorecard (BSC) um dos instrumentos mais vocacionados para este fim. Esta ferramenta, criada por Kaplan e Norton, visa a tradução da estratégia e missão de uma organização em objetivos e medidas divididas por quatro perspetivas diferentes: financeira, clientes, processos internos e aprendizagem e crescimento. O BSC é um modelo bastante flexível e o seu sucesso é reconhecido perante o mundo académico e empresarial. Neste sentido, foi desenvolvida uma proposta de implementação de um BSC para a Clínica Oftalmológica Dr. Miguel Sousa Neves, Lda.. Desta forma, foi definida e proposta uma ferramenta de gestão estratégica, permitindo também destacar um conjunto de melhorias que a mesma poderá trazer à organização. O método de estudo adotado foi o estudo de caso tendo sido realizada uma clarificação das orientações estratégicas da organização em questão através da definição da sua visão, missão e valores e, de seguida, a definição dos objetivos estratégicos e seleção dos indicadores de desempenho para cada perspetiva, garantindo assim o seu alinhamento. Por fim, foi delineado o mapa estratégico onde se apresentam as principais relações de causa-efeito entre as várias perspetivas do BSC. Verificou-se que a organização em análise tem os principais pilares do BSC – missão, valores e visão - bem definidos, tal como uma cultura aberta e comunicação clara, transparente e fluída. Estes elementos são muito relevantes para o início do processo de aplicação do BSC, uma vez que podem facilitar a compreensão e a aceitação do mesmo por parte das pessoas que trabalham na organização. O mapa estratégico desenhado para a Clínica Oftalmológica Dr. Miguel Sousa Neves, Lda. apresenta-se como uma ferramenta útil para a mesma nomeadamente ao fornecer aos funcionários uma linha clara da visão sobre a forma como as suas funções estão ligadas aos objetivos globais da organização; ao definir prioridades; ao identificar, racionalizar e alinhar as diversas iniciativas; ao ligar a estratégia com a afetação dos recursos disponíveis, orientando-os para o apoio ao cumprimento dos objetivos estratégicos da organização e satisfação das necessidades dos utentes; e ao incentivar a aprendizagem e a melhoria contínua dos colaboradores e da organização como um todo. Face ao exposto, o BSC poderá permitir à Clínica concentrar-se nas suas questões essenciais, estabelecendo as relações de causa-efeito para atingir os seus fins.

Feature LDA:a supervised topic model for automatic detection of web API documentations from the web

Web APIs have gained increasing popularity in recent Web service technology development owing to its simplicity of technology stack and the proliferation of mashups. However, efficiently discovering Web APIs and the relevant documentations on the Web is still a challenging task even with the best resources available on the Web. In this paper we cast the problem of detecting the Web API documentations as a text classification problem of classifying a given Web page as Web API associated or not. We propose a supervised generative topic model called feature latent Dirichlet allocation (feaLDA) which offers a generic probabilistic framework for automatic detection of Web APIs. feaLDA not only captures the correspondence between data and the associated class labels, but also provides a mechanism for incorporating side information such as labelled features automatically learned from data that can effectively help improving classification performance. Extensive experiments on our Web APIs documentation dataset shows that the feaLDA model outperforms three strong supervised baselines including naive Bayes, support vector machines, and the maximum entropy model, by over 3% in classification accuracy. In addition, feaLDA also gives superior performance when compared against other existing supervised topic models.

Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants

Objectives - Cationic liposomes of dimethyldioctadecylammonium bromide (DDA) combined with trehalose 6,6'-dibehenate (TDB) elicit strong cell-mediated and antibody immune responses; DDA facilitates antigen adsorption and presentation while TDB potentiates the immune response. To further investigate the role of DDA, DDA was replaced with the neutral lipid of distearoyl-sn-glycero-3-phosphocholine (DSPC) over a series of concentrations and these systems investigated as adjuvants for the delivery of Ag85B–ESAT-6-Rv2660c, a multistage tuberculosis vaccine. Methods - Liposomal were prepared at a 5?:?1 DDA–TDB weight ratio and DDA content incrementally replaced with DSPC. The physicochemical characteristics were assessed (vesicle size, zeta potential and antigen loading), and the ability of these systems to act as adjuvants was considered. Key findings - As DDA was replaced with DSPC within the liposomal formulation, the cationic nature of the vesicles decreases as does electrostatically binding of the anionic H56 antigen (Hybrid56; Ag85B-ESAT6-Rv2660c); however, only when DDA was completed replaced with DSPC did vesicle size increase significantly. T-helper 1 (Th1)-type cell-mediated immune responses reduced. This reduction in responses was attributed to the replacement of DDA with DSPC rather than the reduction in DDA dose concentration within the formulation. Conclusion - These results suggest Th1 responses can be controlled by tailoring the DDA/DSPC ratio within the liposomal adjuvant system.

Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants

Objectives Cationic liposomes of dimethyldioctadecylammonium bromide (DDA) combined with trehalose 6,6′-dibehenate (TDB) elicit strong cell-mediated and antibody immune responses; DDA facilitates antigen adsorption and presentation while TDB potentiates the immune response. To further investigate the role of DDA, DDA was replaced with the neutral lipid of distearoyl-sn- glycero-3-phosphocholine (DSPC) over a series of concentrations and these systems investigated as adjuvants for the delivery of Ag85B-ESAT-6-Rv2660c, a multistage tuberculosis vaccine. Methods Liposomal were prepared at a 5: 1 DDA-TDB weight ratio and DDA content incrementally replaced with DSPC. The physicochemical characteristics were assessed (vesicle size, zeta potential and antigen loading), and the ability of these systems to act as adjuvants was considered. Key findings As DDA was replaced with DSPC within the liposomal formulation, the cationic nature of the vesicles decreases as does electrostatically binding of the anionic H56 antigen (Hybrid56; Ag85B-ESAT6-Rv2660c); however, only when DDA was completed replaced with DSPC did vesicle size increase significantly. T-helper 1 (Th1)-type cell-mediated immune responses reduced. This reduction in responses was attributed to the replacement of DDA with DSPC rather than the reduction in DDA dose concentration within the formulation. Conclusion These results suggest Th1 responses can be controlled by tailoring the DDA/DSPC ratio within the liposomal adjuvant system. © 2013 Royal Pharmaceutical Society.

Effect of Cu and Sn promotion on the catalytic deoxygenation of model and algal lipids to fuel-like hydrocarbons over supported Ni catalysts

The ability of Cu and Sn to promote the performance of a 20% Ni/Al2O3 catalyst in the deoxygenation of lipids to fuel-like hydrocarbons was investigated using model triglyceride and fatty acid feeds, as well as algal lipids. In the semi-batch deoxygenation of tristearin at 260 °C a pronounced promotional effect was observed, a 20% Ni-5% Cu/Al2O3 catalyst affording both higher conversion (97%) and selectivity to C10-C17 alkanes (99%) in comparison with unpromoted 20% Ni/Al2O3 (27% conversion and 87% selectivity to C10-C17). In the same reaction at 350 °C, a 20% Ni-1% Sn/Al2O3 catalyst afforded the best results, giving yields of C10-C17 and C17 of 97% and 55%, respectively, which contrasts with the corresponding values of 87 and 21% obtained over 20% Ni/Al2O3. Equally encouraging results were obtained in the semi-batch deoxygenation of stearic acid at 300 °C, in which the 20% Ni-5% Cu/Al2O3 catalyst afforded the highest yields of C10-C17 and C17. Experiments were also conducted at 260 °C in a fixed bed reactor using triolein − a model unsaturated triglyceride − as the feed. While both 20% Ni/Al2O3 and 20% Ni-5% Cu/Al2O3 achieved quantitative yields of diesel-like hydrocarbons at all reaction times sampled, the Cu-promoted catalyst exhibited higher selectivity to longer chain hydrocarbons, a phenomenon which was also observed in experiments involving algal lipids as the feed. Characterization of fresh and spent catalysts indicates that Cu enhances the reducibility of Ni and suppresses both cracking reactions and coke-induced deactivation.

Synthesis of M2AC (M = Ti, V, Cr, Nb, Zr, A = Al, Sn, S) (MAX) carbide phases and study of their physical behavior under extreme conditions

Materials known as Mn+1AXn phases, where n is 1, 2, or 3, and M represents an early transition metal, A an A-group element, and X is either Carbon and/or Nitrogen [1], are fast becoming technologically important materials due to the interesting combination of unique properties. However, a lot of important information about the high temperature and high pressure behavior of many of these compounds is still missing, which needs to be determined systematically. ^ In this dissertation the synthesis of M2AC (M = Ti, V, Cr, Nb, Zr) and A = (Al, Sn, S) compounds by arc melting, vacuum sintering and piston cylinder synthesis is presented along with the synthesis of Zr 2SC, which has been synthesized for first time in bulk form, by piston cylinder technique. The microstructural analysis by electron microscopy and phase analysis by x-ray diffraction is presented next. Finally, a critical analysis of the behavior of these compounds under the application of extreme pressure (as high as 50 GPa) and temperature (≈ 1000°C) is presented. ^ The high pressure studies, up to 50 GPa, showed that these compounds were structurally intact and their bulk moduli ranged from 140 to 190 GPa. The high temperature studies in the inert atmosphere showed that the M 2SnC compounds were unstable above 650°C and the expansion along the a-axis was higher than that along the c-axis, unlike the other phases. M2SC compounds on the other hand showed negligible difference in the thermal expansion along the two axes. The oxidation study revealed that Ti2AC (Al, S) compounds had highest resistance to oxidation while the M2SnC compounds had the least. Furthermore, from the oxidation study of these compounds, which were short time oxidation experiments, it was found that all of these compounds oxidized to their respective binary oxides. ^

Produção de estrutura com gradiente de porosidade a partir da sinterização por plasma da mistura de pós Ti-Nb-Sn

Porous structures are being widely investigated for use in biomedical implants, aiming to mechanically integrate and functionally the implant inside the bone tissue. Moreover, this structure is also important for drugs that can be stored and can induce and accelerate the process of osseointegration. With the purpose to investigate this effect, Ti, Nb and Sn metal powders, were sintered by plasma using a hollow cathode discharge. Sintering was performed in argon plasma set at 4 mbar pressure and temperatures of 500 ° C, 600 ° C and 700 ° C. Samples were also sintered in the electrical resistance furnace at 1200 ° C in order to compare plasma sintering with the conventional method. It was observed that plasma samples sintered with the hollow cathode configuration showed a gradient in porosity, while the samples sintered in the resistive furnace did not. Furthermore, differences in the microstructure of the samples were found, were a surface with higher porosity and ales porous core were obtained at different temperatures. The percolation profile of distilled water and the chemical compositions of the porous layers of the plasma treated samples were the main results obtained. Based on these results, we can conclude that this structure is particularly important for application in the biomedical field such as scaffolds for drug delivery and implants

Consolidação de processos chave do sistema de gestão da qualidade (da empresa Dário Albano Zina Pimpão Lda – Ginja de Óbidos Oppidum)

A Dário Albano Zina Pimpão Lda é uma pequena empresa familiar constituída em 1985 que fabrica artesanalmente produtos genuínos, de qualidade premium. A gerência da empresa é partilhada por Dário Pimpão (Pai) e Marta Pimpão (Filha), em que Dário Pimpão assume a responsabilidade pela área produtiva, sendo o líder carismático da organização, e Marta Pimpão movimenta-se nas restantes áreas (comercial, financeira, marketing). Produz licor de ginja de Óbidos Oppidum (com e sem elas – ou seja, com ou sem fruto) de forma artesanal e 100% natural, licor de ginja com chocolate e bombons com licor de ginja. O seu know-how faz com que estes produtos sejam de elevada qualidade, considerado um licor gourmet e de categoria premium. O mercado consumidor dos produtos da DAZP é abrangente a homens e mulheres, embora se observe uma maior adesão por parte das mulheres, talvez pelo facto de o licor ser doce e bastante frutado. O facto do licor de ginja Oppidum ser considerado um produto premium faz com que classes médias altas/altas tenham maior apetência para o adquirir, assim como idades entre 30 – 70 anos. Depois de anos consecutivos com taxas de crescimento positivas e crescentes, a Oppidum enfrenta agora a necessidade de uma maior consolidação do mercado interno, em Portugal. Com as atuais condições económicas e financeiras cada vez mais desfavoráveis para todos os agentes económicos portugueses no geral, e também para os consumidores, a Oppidum defronta-se com o desafio de desenvolver novas estratégias que façam face às novas tendências de mercado advindas destas alterações. Para além disso, a procura por parte de consumidores estrangeiros remete para a ideia de que a Oppidum tem potencial e atingiu uma posição em que a sua internacionalização e exportação poderá ser uma mais-valia para a empresa e o próximo passo para o seu desenvolvimento e crescimento. Este projeto trata precisamente da abordagem destas duas novas vertentes da marca Oppidum: consolidação do mercado interno e processo de internacionalização, começando por apresentar uma análise da situação atual da empresa, de modo a que posteriormente se possa definir como quer estar no futuro e enumerar as ferramentas precisas para alcançar as suas metas e objetivos. Pretende-se também definir os próximos passos, quer a nível operacional, financeiro ou estratégico, através de um cronograma de forma a garantir o sucesso da realização deste projeto com a entrada do Licor de Ginja Oppidum no mercado EUA durante o ano 2016. Para concluir, serão realizadas também decisões económicas e financeiras inerentes à expansão internacional e consolidação do mercado interno, indicando-se os pressupostos utilizados para a previsão de receitas nacionais e internacionais assim como também todos os custos associados ao projeto, fundamentando as estimativas de vendas.

Scheduling Optimization with LDA and Greedy Algorithm

Scheduling optimization is concerned with the optimal allocation of events to time slots. In this paper, we look at one particular example of scheduling problems - the 2015 Joint Statistical Meetings. We want to assign each session among similar topics to time slots to reduce scheduling conflicts. Chapter 1 briefly talks about the motivation for this example as well as the constraints and the optimality criterion. Chapter 2 proposes use of Latent Dirichlet Allocation (LDA) to identify the topic proportions in each session and talks about the fitting of the model. Chapter 3 translates these ideas into a mathematical formulation and introduces a Greedy Algorithm to minimize conflicts. Chapter 4 demonstrates the improvement of the scheduling with this method.

Adesp. fr. 700 K.-Sn. y "Andrómeda" de Eurípides

adesp. fr. 700 Kn.-Sn. podría proceder de Andrómeda de Eurípides y no de una Níobe. Los siguientes elementos de los frs. (a) y (b) pueden responder a lo que se conoce de la tragedia de Eurípides: (a) la semejanza con una estatua; (b) la novia de Hades; (c) el silencio del personaje; (d) la colaboración con las Moiras; (e) el contraste entre la fortuna regia y la desgracia y el sufrimiento de los padres. No es, por tanto, necesario modificar el texto recibido para eliminar μάγους πάγας y la referencia a las trampas mágicas en el v. 5, que cuadra bien con Medusa y Perseo.