Apianus Alexandrinus De bellis ciuilibus ... [P. Candidi ... in latinum traductis]

Sign.: a8, b-z6, [et]6, [cum]6, [rum]6, A6, B-C8

Diana desenterrada : antiguas memorias y breve recopilacion de los mas notables sucessos de la ciudad de Denia, y su famoso templo de Diana : desde su antiquisima fundacion hasta el estado presente

Explicit : "... / y a su pesar desentierra / de Diana la memoria."

Los Triumphos de Apiano

Traductor consta en preliminares

Triunfos gloriosos de la monarquia de España ...

Según Palau, 42271 y Aguilar Piñal, 1036 el autor es Canicia y Rotla, Luis Pascual

Historia del arte

Historia del arte / apuntes tomados a D. Leopoldo Torres Balbas

L'Impero moderno d'Alemagna [Texto impreso] : epitome istorica

Copia digital: Biblioteca Valenciana, 2011

Genetic evidence for the role of GDP-mannose in plant ascorbic acid (vitamin C) biosynthesis

Vitamin C (l-ascorbic acid; AsA) acts as a potent antioxidant and cellular reductant in plants and animals. AsA has long been known to have many critical physiological roles in plants, yet its biosynthesis is only currently being defined. A pathway for AsA biosynthesis that features GDP-mannose and l-galactose has recently been proposed for plants. We have isolated a collection of AsA-deficient mutants of Arabidopsis thaliana that are valuable tools for testing of an AsA biosynthetic pathway. The best-characterized of these mutants (vtc1) contains ≈25% of wild-type AsA and is defective in AsA biosynthesis. By using a combination of biochemical, molecular, and genetic techniques, we have demonstrated that the VTC1 locus encodes a GDP-mannose pyrophosphorylase (mannose-1-P guanyltransferase). This enzyme provides GDP-mannose, which is used for cell wall carbohydrate biosynthesis and protein glycosylation as well as for AsA biosynthesis. In addition to genetically defining the first locus involved in AsA biosynthesis, this work highlights the power of using traditional mutagenesis techniques coupled with the Arabidopsis Genome Initiative to rapidly clone physiologically important genes.

Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor.

Predictive methods, physicochemical measurements, and structure activity relationship studies suggest that corticotropin-releasing factor (CRF; corticoliberin), its family members, and competitive antagonists (resulting from N-terminal deletions) usually assume an alpha-helical conformation when interacting with the CRF receptor(s). To test this hypothesis further, we have scanned the whole sequence of the CRF antagonist [D-Phe12,Nle21,38]r/hCRF-(12-41) (r/hCRF, rat/human CRF; Nle, norleucine) with an i-(i + 3) bridge consisting of the Glu-Xaa-Xaa-Lys scaffold. We have found astressin [cyclo(30-33)[D-Phe12,Nle21,38,Glu30,Lys33]r/ hCRF(12-41)] to be approximately 30 times more potent than [D-Phe12,Nle21,38]r/hCRF-(12-41), our present standard, and 300 times more potent than the corresponding linear analog in an in vitro pituitary cell culture assay. Astressin has low affinity for the CRF binding protein and high affinity (Ki = 2 nM) for the cloned pituitary receptor. Radioiodinated [D-125I-Tyr12]astressin was found to be a reliable ligand for binding assays. In vivo, astressin is significantly more potent than any previously tested antagonist in reducing hypophyseal corticotropin (ACTH) secretion in stressed or adrenalectomized rats. The cyclo(30-33)[Ac-Pro4,D-Phe12,Nle21,38,Glu30,Lys33++ +]r/hCRF-(4-41) agonist and its linear analog are nearly equipotent, while the antagonist astressin and its linear form vary greatly in their potencies. This suggests that the lactam cyclization reinstates a structural constraint in the antagonists that is normally induced by the N terminus of the agonist.

Dª Carmen Chamizo Vega

In this text, the author describes the characteristics of their professional and personal relationship with Dr. Carmen Chamizo Vega and expresses regret for her loss.

Evaluation of the usability and benefits of twist wire GMAW and FACW narrow gap welding /

"March 1988."

Bollettino d'arte.

Title varies slightly.

Julien l'apostat : précédé d'une étude sur la formation du christianisme /

Mode of access: Internet.

Memoires de litterature et d'histoire /

Mode of access: Internet.