Avaliação de compósitos á base de celulose bacteriana-hidroxiapatita com peptídeo osteogênico para reparação óssea

Pós-graduação em Odontologia - FOAR

Avaliação histológica do processo de reparação do tecido ósseo do rato frente à aplicação de um adesivo à base de cianoacrilato

This research objective was to verify the tissues reactions obtained, in surgical experimental bone defect, after the etil cyanoacrylate chemical adhesive application in rats parietal bones. 1t was investigated the acceptance or no acceptance of the tissues surround the bone defect in which was placed the etil cyanoacrylate and the control bone defect. The specimens were submitted to light microscopic analysis. 24 adults rats were used (Rattus norvergicus, albinus, Wistar) with the average weight to 300 gr. and were divided in two groups: treated and control. After the bone defects were realized, etil cyanoacrylate was placed over one of the defects at the parietal bone (treated group). On the other defect nothing was placed and it was used like control group. After 24 hours, 3,5,7,30 and sixty days after surgery, for animals of each group were sacrificed. The bone samples were removed and fixed in 10% formalin during 72 hours and analyzed using light microscopy. The results showed that the acute inflammatory responses was more observed at lhe treated group than the control group. The chemical adhesive was observed until 60 days follow the surgery and the tissues around it present normal appearance. The chemical adhesive, etil cyanaocrylate, did not impede at the bone repair process

Influência da sinvastatina na reparação óssea de mandíbulas da ratas ovariectomizadas e nos níveis de colesterol sanguíneo

Pós-graduação em Biopatologia Bucal - ICT

REPARAÇÃO DE HÉRNIA PERINEAL EM CÃES COM PERITÔNIO DE BOVINO CONSERVADO EM GLICERINA

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Coptotermes gestroi (Isoptera, Rhinotermitidae): revisão da distribuição geográfica, danos e análise de sobrevivência após exposição a bambu termorretificado

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Influência do SNP T3801C CYP1A1 sobre os níveis de danos oxidativos no DNA de células da mucosa gástrica de pacientes infectados pelo H. Pylori

Helicobacter pylori (H. pylori) is a common gastric pathogen that has infected more than 50% of the population of the world and it has been associated with chronic gastritis, gastric ulcers, duodenal ulcer, and gastric cancer. Although, almost all infected people develop gastritis, there is a variety of clinical outcomes, and only a minority (<1%) of infected individuals develop gastric cancer. There are evidences which suggest that the chronic inflammatory reaction caused by the bacterial infection may be involved in the production of reactive oxygen species or reactive nitrogen species. It may lead to DNA damage, which together with the cellular response could lead to gene mutations, chromosomal aberrations characterizing genomic instability that may represent the early step in gastric carcinogenesis. The extent and severity of gastric mucosal inflammation, as well as the clinical outcome of the infection, depend on a number of factors, including the host genetic susceptibility such SNP T3801 CYP1A1, immune response, age at which the infection was acquired, environmental factors, especially dietary and bacterial virulence factors. Due to the risk of developing gastric cancer in humans infected by H. pylori, we used the Comet Assay to investigate the influence of the SNP T3801C CYP1A1 on levels of oxidative DNA damage in gastric epithelial cells. The study was conducted with biopsies from the gastric antrum and corpus of 103 H. pylori-infected patients and 24 uninfected control patients. Genotype of SNP T3801C CYP1A1 was determined by PCR-RFLP and DNA damage levels were measured in gastric mucosal cells from antrum and corpus by the Comet assay. Levels of DNA damage in gastric mucosa cells from antrum and corpus of H. pylori-infected patients with mild, moderate, severe gastritis, and gastric cancer were significantly higher compared to uninfected normal mucosa cells. However, levels... (Complete abstract click electronic access below)

Avaliação dos danos por fluência da serpentina da caldeira da REVAP

The determination of the remaining life of equipment operating at high temperatures has been a great challenge for their owners. The use of safety factors, often conservative, makes the replacement of equipment or of its components at the end of the life of design gets financially unviable. This study aimed to estimate the remaining life of the serpentine of the secondary superheater of one of REVAP’s boilers (Henrique Lage Refinery), through accelerated creep tests and comparison of the results with the techniques based on microstructure and hardness. When conducting a proper assessment it’s possible to increase the equipment reliability, ensuring operational continuity and physical integrity. The tests showed a minimal residual life of 12.7 years (111,252 hours), longer than the design life (100,000 hours), even after a period of operation of approximately 250,000 hours, confirming the conservatism of the project. The techniques based on microstructure and hardness did not show good correlation with the creep test, decreasing the reliability of these techniques in determining the residual life

Biomateriais e terapia celular na reparação da cartilagem articular em equinos

Articular cartilage is the structure that coats the bone ends in regions where two bones are articulated, allowing movement. It has inefficient intrinsic and extrinsic mechanisms of repair, usually resulting in fibrocartilage formation after injury. Such repair have lower strength, stiffness and usability features when compared to hyaline cartilage. The mesenchymal stem cells have the potential to regenerate tissue without the production of scar, and because of this feature it is well studied. But to have its maximum chondrogenic potential, it is necessary to use scaffolds and growth factors. Biomaterials play the role of scaffold for the cells allowing them to become attached, grow and produce extracellular matrix, leading to formation of repair with hyaline cartilage. In this sense, the purpose of this study is to provide information on the various studies using cell therapy and / or biomaterials to produce hyaline cartilage

O romance como veículo de preenchimento da falta humana: Reparação de Ian McEwan

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Reparação de enxertos ósseos autógenos recobertos ou não por membrana de ptfe-e em ratas ovariectomizadas. Estudo histológico e histomorfométrico

Abstract : The objective of this study was to evaluate quantitatively and to describe qualitatively the process of bone repair in the interface of receptor bed and graft autogenous bone block with or without a e-PTFE membrane, in osteopenia induced rats. To this end, we used forty-eight Wistar rats weighing about 300g, in which, with the aid of 4.1 mm trephine a graft was removed from the parietal bone and fixed to the surface of the left mandibular ramus. The animals were randomly divided into four experimental groups: Group 1 (n=12): SHAM operated and autogenous bone graft only; Group 2 (n=12): SHAM and autogenous bone graft covered by e-PTFE membrane; Group 3 (n=12): ovariectomized rats (OVX) and autogenous bone graft only; Group 4 (n=12): OVX and autogenous bone graft covered by e-PTFE membrane. The animals in each group were sacrificed at three time periods: 21, 45 and 60 days, each time with 4 animals per group. The specimens were decalcified and included, the sections were stained with HE and subjected to histological and histomorphometric analysis in light microscopy. The results of the ANOVA showed that the variables on the condition (OVZ and SHAM), and the time (21, 45 and 60 days) were statistically significant, and can be established with the Tukey test (5%) that the period 21-day differs significantly from the periods of 45 and 60 days, which did not differ among themselves. The descriptive histological analysis showed integration of the graft in all animals. It was concluded that the initial integration of the graft bed was negatively affected in the presence of induced osteopenia, and that the use or not of a e-PTFE membrane did not interfere in the process of integration

Reparação óssea em alvéolos de ratas ovarectomizadas após implante com biovidro: análise histomorfométrica e imunoistoquímica

Pós-graduação em Odontologia - FOA

Avaliação de danos oxidativos no DNA de linfócitos e estresse oxidativo no plasma de pacientes a cirurgia sob anestesia balanceada com sevoflurano

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação do processo de reparação tecidual após Exérese realizada com bisturi convencional e bisturi harmônico Harmonic® de necrose induzida em língua de rato: estudo macroscópico e histológico

Pós-graduação em Biopatologia Bucal - ICT

Efeito da administração de alendronato, a longo prazo, sobre as propriedades mecânicas do tecido ósseo, sua reparação e mineralização ao redor de implantes osseointegráveis. Estudo em ratas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)