905 resultados para Radioisotopes in animal culture.
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Published also as thesis (PH. D.) Columbia University, 1918.
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Mode of access: Internet.
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Mode of access: Internet.
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Mode of access: Internet.
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"January 1981."
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Mode of access: Internet.
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Paged continuously.
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"Designed specifically to teach professional industrial personnel the basic considerations in the application of radioisotopes to industrial work."
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Running title: Phosphorus metabolism.
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Prepared for the U. S. Environmental Protection Agency, Office of Research and Development, Monitoring Systems Research and Development Division, Environmental Monitoring and Support Laboratory, Las Vegas, Nev.
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Noroviruses are understudied because these important enteric pathogens have not been cultured to date. We found that the norovirus murine norovirus 1 (MNV-1) infects macrophage-like cells in vivo and replicates in cultured primary dendritic cells and macrophages. MNV-1 growth was inhibited by the interferon-alphabeta receptor and STAT-1, and was associated with extensive rearrangements of intracellular membranes. An amino acid substitution in the capsid protein of serially passaged MNV-1 was associated with virulence attenuation in vivo. This is the first report of replication of a norovirus in cell culture. The capacity of MNV-1 to replicate in a STAT-1-regulated fashion and the unexpected tropism of a norovirus for cells of the hematopoietic lineage provide important insights into norovirus biology.