O artigo 1.228 do Código Civil e os deveres do proprietário em matéria de preservação do meio ambiente

Inclui notas explicativas, bibliográficas e bibliografia

Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins

Acute promyelocytic leukemia (APL) is associated with chromosomal translocations always involving the RARα gene, which variably fuses to one of several distinct loci, including PML or PLZF (X genes) in t(15;17) or t(11;17), respectively. APL in patients harboring t(15;17) responds well to retinoic acid (RA) treatment and chemotherapy, whereas t(11;17) APL responds poorly to both treatments, thus defining a distinct syndrome. Here, we show that RA, As2O3, and RA + As2O3 prolonged survival in either leukemic PML-RARα transgenic mice or nude mice transplanted with PML-RARα leukemic cells. RA + As2O3 prolonged survival compared with treatment with either drug alone. In contrast, neither in PLZF-RARα transgenic mice nor in nude mice transplanted with PLZF-RARα cells did any of the three regimens induce complete disease remission. Unexpectedly, therapeutic doses of RA and RA + As2O3 can induce, both in vivo and in vitro, the degradation of either PML-RARα or PLZF-RARα proteins, suggesting that the maintenance of the leukemic phenotype depends on the continuous presence of the former, but not the latter. Our findings lead to three major conclusions with relevant therapeutic implications: (i) the X-RARα oncoprotein directly determines response to treatment and plays a distinct role in the maintenance of the malignant phenotype; (ii) As2O3 and/or As2O3 + RA combination may be beneficial for the treatment of t(15;17) APL but not for t(11;17) APL; and (iii) therapeutic strategies aimed solely at degrading the X-RARα oncoprotein may not be effective in t(11;17) APL.

Hādhā kitāb Kashf al-labs ʻan ḥadīth waḍʻ al-yad ʻalá al-raʼs

li-ʻAbd al-Ḥayy ibn Abī al-Makārim ʻAbd al-Kabīr al-Kattānī.

Sharḥ al-ʻallāmah al-muḥaqqiq al-fahhāmah al-mudaqqiq al-muqriʼ al-naḥrīr al-walī al-ṣāliḥ al-shahīr al-Shaykh Sayyidī ʻAbd al-Raḥmān ibn Muḥammad ibn Makhlūf al-Thaʻālibī al-Jaʻfarī al-musammá al-Mukhtār min al-jawāmiʻ fī muḥādhāt al-Durar al-lawāmiʻ fī aṣl maqraʼ al-Imām Nāfiʻ lil-Shaykh Abī al-Ḥasan ʻAlī al-maʻrūf bi-Ibn Barrī

Includes the text of Ibn Barrī's "al-Durar al-lawāmiʻ".

Hādhā kitāb al-Farāʼid al-raḍwīyah

min taʼlīfāt Mīrzā Muḥammad ibn Sulaymān al-Tunukābunī.

Hādhā kitāb Ḥusn al-muḥāḍarah fī akhbār Miṣr wa-al-Qāhirah / lil-Imām al-Mujtahid al-Ḥafīẓ Jalāl al-Dīn ʻAbd al-Raḥmān al-Asyūṭī : manuscript, 1844

Vol. 1 of a multi-volume set.