[Illustrations de La vie inestimable du grand Gargantua, père de Pantagruel, jadis composée par l'abstracteur de quinte essence. Livre plein de pantagruelisme. / [non identifié] ; François Rabelais, aut. du texte

Comprend : [Bandeau et lettrine au Prologue de l'auteur p.2 : le maître et son disciple] [Cote : microfilm R 18678] ; [Bandeau au chap. I en reg. p.6 :] De la généalogie et antiquité de Gargantua. [L'auteur rédigeant les chroniques pantagruelines.] [Cote : microfilm R 18678]

[Illustrations du Quart livre des faictz et dictz héroïques du noble Pantagruel.] / François Rabelais, aut. du texte

Comprend : [Livre IV. Fig. au Prologue : François Rabelais rédigeant les aventures de Pantagruel.] [Cote : microfilm R 28836] ; [Livre IV. Chap. Ier. Fig. au titre :] Comment Pantagruel monta sur mer pour visiter l'Oracle de la divine bouteille [Cote : microfilm R 28836] ; [Livre IV. Chap. II. Fig. au titre :] Comment Pantagruel rencontra un navire de voyageurs retournans du pays Lanternois. [Cote : microfilm R 28836] ; [Livre IV. Chap. III. Fig. au titre :] Comment Panurge feit noyer en mer les moutons et le marchant qui les conduisoit [Cote : microfilm R 28836] ; [Livre IV. Chap. IV. Fig. au titre :] Comment Pantagruel arriva en l'Isle Eunasin, et des estranges alliances du pays. [Cote : microfilm R 28836] ; [Livre IV. Chap. V. Fig. au titre :] Comment Pantagruel descendit en l'Isle de Chely, en laquelle regnoit Panigon [Cote : microfilm R 28836] ; [Livre IV. Chap. VI. Fig. au titre :] Comment nous passasmes Procuration et de l'estrange maniere de vivre entre les Chicquanoux. [Cote : microfilm R 28836] ; [Livre IV. Chap. VII. Fig. au titre :] Comment Pantagruel passa les Isles de Tohu et Bohu et de l'estrange mort de Bringuenaril les avaleurs de moulins à vent [Cote : microfilm R 28836] ; [Livre IV. Chap. IX. Fig. au titre :] Quelles contenances eurent Panurge et frere Jean durant la tempeste [Cote : microfilm R 28836]

[Illustrations du Cinquiesme et dernier livre des faicts et dicts héroïques du bon Pantagruel.] / François Rabelais, aut. du texte

Comprend : [Feuille dépl. en fin de vol. : la bouteille de l'oracle.] [Cote : microfilm R 19461]

[Illustrations de La vie très horrificque du Grand Gargantua, pere de Pantagruel jadis composée par M.Alcofribas abstracteur de quinte essence.] / François Rabelais, aut. du texte

Comprend : [Frontispice : portrait de Rabelais]. [Cote : microfilm R 9848] ; [2ème Frontispice en médaillon : portrait de Rabelais]. [Cote : microfilm R 9848] ; [Bandeau au Prologue de l'auteur. f.2 : l'auteur rédigeant les aventures de Gargantua]. [Cote : microfilm R 9848] ; [Fig. au chap. III, en reg. f.11 : les repas de Grandgousier, père de Gargantua]. [Cote : microfilm R 9848] ; [Fig. au chap. VI. f.17 :] Comment Gargantua nasquit en facon bien estrange. [Cote : microfilm R 9848] ; [Fig. au chap. VIII. en reg. f.22 :] Comment on vestit Gargantua. [Cote : microfilm R 9848] ; [Fig. au chap. XII. en reg. f.34 :] Des chevaulx factices de Gargantua. [Cote : microfilm R 9848] ; [Fig. au chap. XV. f.42 :] Comment Gargantua fut mis soubz aultres pedagoges. [Cote : microfilm R 9848] ; [Fig. au chap. XIX. f.49 :] La harangue de maistre Jonatus de Bragmardo faicte a Gargantua pour recouvrer les cloches. [Cote : microfilm R 9848] ; [Fig. au chap. XXXV. f.98 :] Comment Gymnaste soupplement tua le capitaine Tripet et aultres gens de Picrochole. [Cote : microfilm R 9848] ; [Fig. au chap. XXXVIII. en reg. f.105 :] Comment Gargantua mangea en sallade six pelerins. [Cote : microfilm R 9848]

Errors in palliative care: kinds, causes, and consequences: a pilot survey of experiences and attitudes of palliative care professionals.

Abstract Background: Medical errors have recently been recognized as a relevant concern in public health, and increasing research efforts have been made to find ways of improving patient safety. In palliative care, however, studies on errors are scant. Objective: Our aim was to gather pilot data concerning experiences and attitudes of palliative care professionals on this topic. Methods: We developed a questionnaire, which consists of questions on relevance, estimated frequency, kinds and severity of errors, their causes and consequences, and the way palliative care professionals handle them. The questionnaire was sent to all specialist palliative care institutions in the region of Bavaria, Germany (n=168; inhabitants 12.5 million) reaching a response rate of 42% (n=70). Results: Errors in palliative care were regarded as a highly relevant problem (median 8 on a 10-point numeric rating scale). Most respondents experienced a moderate frequency of errors (1-10 per 100 patients). Errors in communication were estimated to be more common than those in symptom control. The causes most often mentioned were deficits in communication or organization. Moral and psychological problems for the person committing the error were seen as more frequent than consequences for the patient. Ninety percent of respondents declared that they disclose errors to the harmed patient. For 78% of the professionals, the issue was not a part of their professional training. Conclusion: Professionals acknowledge errors-in particular errors in communication-to be a common and relevant problem in palliative care, one that has, however, been neglected in training and research.

[Illustrations de Arlequin] / Tristano Martinelli, aut. du texte

Comprend : [Fig. p. de titre : Arlequin ou] Arlechin. [Cote : microfilm R 26976] ; [Fig. p. 5 : la demande d'Arlequin ]. [Cote : microfilm R 26976] ; [Pl. en reg. p.7 :] Quantumque la chaine et la Medaglia Pour la monstrer à ces Messieurs d'Itaglia. [Cote : microfilm R 26976] ; [Pl. p. 48 :] A Dieu mon Roy et Reine et mes Amis Pour vous obeyr je m'en vay à Paris. [Cote : microfilm R 26976] ; [Pl. p. 50 :] Fradeli à menenuo con Arlechin A guadagnar un poco di quatrin. [Cote : microfilm R 26976] ; [Pl. p. 51 :] Vammo à Paris à fé da Cavagler Que gannaremo aglia bien da comer. [Cote : microfilm R 26976]

Rapid transgene expression in multiple precursor cell types of adult rat subventricular zone mediated by adeno-associated type 1 vectors.

Abstract The adult rat brain subventricular zone (SVZ) contains proliferative precursors that migrate to the olfactory bulb (OB) and differentiate into mature neurons. Recruitment of precursors constitutes a potential avenue for brain repair. We have investigated the kinetics and cellular specificity of transgene expression mediated by AAV2/1 vectors (i.e., adeno-associated virus type 2 pseudotyped with AAV1 capsid) in the SVZ. Self-complementary (sc) and single-stranded (ss) AAV2/1 vectors mediated efficient GFP expression, respectively, at 17 and 24 hr postinjection. Transgene expression was efficient in all the rapidly proliferating cells types, that is, Mash1(+) precursors (30% of the GFP(+) cells), Dlx2(+) neuronal progenitors (55%), Olig2(+) oligodendrocyte progenitors (35%), and doublecortin-positive (Dcx(+)) migrating cells (40%), but not in the slowly proliferating glial fibrillary acidic protein-positive (GFAP(+)) neural stem cell pool (5%). Because cell cycle arrest by wild-type and recombinant AAV has been described in primary cultures, we examined SVZ proliferative activity after vector injection. Indeed, cell proliferation was reduced immediately after vector injection but was normal after 1 month. In contrast, migration and differentiation of GFP(+) precursors were unaltered. Indeed, the proportion of Dcx(+) cells was similar in the injected and contralateral hemispheres. Furthermore, 1 month after vector injection into the SVZ, GFP(+) cells, found, as expected, in the OB granular cell layer, were mature GABAergic neurons. In conclusion, the rapid and efficient transgene expression in SVZ neural precursors mediated by scAAV2/1 vectors underlines their potential usefulness for brain repair via recruitment of immature cells. The observed transient precursor proliferation inhibition, not affecting their migration and differentiation, will likely not compromise this strategy.

Prise en charge initiate du sepsis sévère et du choc septique [Management of severe sepsis and septic shock].

Severe sepsis and septic shock are systemic manifestations of the host response to infection. Mortality remains high despite advances in pathophysiological knowledge. Hemodynamic and respiratory management is largely supportive, while early antibiotics administration and source of infection's control are crucial for patient outcome. We review the principles guiding the initial management of these patients in emergency situation.