Biodegradable Nanoparticles Containing Benzopsoralens: An Attractive Strategy for Modifying Vascular Function in Pathological Skin Disorders

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Thermoanalytical study of praziquantel-loaded PLGA nanoparticles

Polymeric nanoparticles have received great attention as potential controlled drug delivery systems. Biodegradable polymers has been extensively used in the development of these drug carriers, and the polyesters such as polylactic acid, polyglycolic acid and their copolymers as poly-lactide-co- glycolide are the most used, considering its biocompatibility and biodegradability. Thermal analysis techniques have been used for pharmaceutical substances for more than 30 years and are routine methods for screening drug-excipient interactions. The aim of this work is to use thermal analysis to characterize PLGA nanoparticles containing a hydrophobic drug, praziquantel. The results show that the drug is in an amorphous state or in disordered crystalline phase of molecular dispersion in the PLGA polymeric matrix and that the microencapsulation process did not interfere with the chemical structure of the polymer, mantaining the structural drug integrity.

Micropartículas biodegradáveis para liberação prolongada intraocular de cetorolaco de trometamina obtidas po Spray Drying

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo das propriedades elétro-óptica de dispositivos eletroluminescentes confeccionados com um compósito híbrido

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Micropartículas de ácido poli lático-co-glicólico obtidas por Spray Drying para liberação prolongada intra-ocular de fármacos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeitos do calor e da ação microbiana em filmes de PHBV / PP-co-PE aditivados em solo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Biodegradação de filmes de polietileno de baixa densidade (PEBD), polihidroxibutirato-co-hidroxivalerato (PHBV) e blenda de PEBD/PHBV (70/30), em coluna de solo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Safety assessment of oral photodynamic therapy in rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Preparação e caracterização de nanocompósitos de Fe@SiO2, Fe@Fe3O4 e Fe3O4@PNIPAM

Pós-graduação em Química - IQ

Surface characterization and osteoblast-like cells culture on collagen modified PLDLA scaffolds

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento de hidrogéis nanoestruturados baseados em polissacarídeo e zeólita para aplicação em sistemas de liberação controlada

Pós-graduação em Ciência dos Materiais - FEIS

Análises físico-químicas e biológicas de diferentes scaffolds à base de polihidroxibutirato e polihidroxibutirato-co-valerato

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análises físico-químicas e biológicas de diferentes scaffolds à base de polihidroxibutirato e polihidroxibutirato-co-valerato

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Compatibilization of polypropylene/poly(3-hydroxybutyrate) blends

Blending polypropylene (PP) with biodegradable poly(3-hydroxybutyrate) (PHB) can be a nice alternative to minimize the disposal problem of PP and the intrinsic brittleness that restricts PHB applications. However, to achieve acceptable engineering properties, the blend needs to be compatibilized because of the immiscibility between PP and PHB. In this work, PP/PHB blends were prepared with different types of copolymers as possible compatibilizers: poly(propylene-g-maleic anhydride) (PPMAH), poly (ethylene-co-methyl acrylate) [P(EMA)], poly(ethylene-co-glycidyl methacrylate) [P(EGMA)], and poly(ethylene-co-methyl acrylate-co-glycidyl methacrylate) [P(EMAGMA)]. The effect of each copolymer on the morphology and mechanical properties of the blends was investigated. The results show that the compatibilizers efficiency decreased in this order: P(EMAGMA) > P(EMA) > P(EGMA) > PP-MAH; we explained this by taking into consideration the affinity degree of the compatibilizers with the PP matrix, the compatibilizers properties, and their ability to provide physical and/or reactive compatibilization with PHB. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: 3511-3519, 2012