980 resultados para Phi Beta Kappa. Alpha of Rhode Island (Brown University)


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Caption title.

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Argument of Mr. Hazard, counsel for the complainant, given before the Supreme court of the United States.

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Page vi incorrectly numbered iv.

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Mode of access: Internet.

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Series title also at head of t.-p.

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Shipping list no.: 2003-0272-P.

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"Rules and regulations are not included in this book as they are in the process of revision."--Slip inserted.

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A collection of miscellaneous pamphlets.

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"Submitted by Northwest Regional Educational Laboratory, Literacy & Language Program ... Stephen Reder, Project Director."--T.p.

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Each no. has also a distinctive title.

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Thesis (doctoral)--Friedrich-Wilhelms-Universitat zu Berlin, 1894.

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Beta-cell failure coupled with insulin resistance is a key factor in the development of type 2 diabetes. Changes in circulating levels of adipokines, factors released from adipose tissue, form a significant link between excessive adiposity in obesity and both aforementioned factors. In this review we consider the published evidence for the role of individual adipokines on the function, proliferation, death and failure of beta-cells, focusing on those reported to have the most significant effects (leptin, adiponectin, TNFa, resistin, visfatin, DPP-IV and apelin). It is apparent that some adipokines have beneficial effects whereas others have detrimental properties; the overall contribution to beta-cell failure of changed concentrations of adipokines in the blood of obese pre-diabetic subjects will be highly dependent on the balance between these effects and the interactions between the adipokines which act on the beta-cell via a number of intersecting intracellular signalling pathways. We emphasise the importance, and comparative dearth, of studies into the combined effects of adipokines on beta-cells.