285 resultados para Nys, Gudrun M. S


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A környezeti hatások rendszerint túlmutatnak egy vállalat határain, éppen ezért az ellátási lánc kontextusban a környezeti szempontok érvényesítése során fontos szerep jut a beszerzési döntéseknek is. Számos olyan példát lehetne említeni, amikor egy adott szempont szerint egy alternatíva környezetileg elÅ‘nyös, de az ellátási lánc egészét nézve ¡r környezetterhelÅ‘. A környezeti hatások ellátási lánc szinten való ©rése azonban komoly kihívásokat jelent. Ezzel jelentÅ‘s kutatásokat és fejlesztéseket inspirált a téma. Az egyik olyan terület, amelyben komoly kutatási ered©nyek születtek, az a környezeti szempontok beszállítói értékelésbe való beépítése. A kutatások ezen irányához csatlakozva a szerzÅ‘k tanul¡nyunkban azt keresik, hogyan lehet meghatározni az egyik legáltalánosabban használt szállítóértékelési ³dszerben, a súlyozott pontrendszerben egy adott szemponthoz azt a súlyt, amely mellett az adott szempont ¡r döntésbefolyásoló tényezÅ‘vé válik. Ehhez a DEA (Data Envelopment Analysis) összetett indikátorok (Composite Indicators, CI) ³dszerét alkalmazzák. A szempontok közös súlyának fontossága megállapításához a lineáris programozás el©letét használják. _____ Management decisions often have an environmental effect not just within the company, but outside as well, this is why supply chain context is highlighted in literature. Measuring environmental issues of supply decisions raise a lot of problems from methodological and practical point of view. This inspires a rapidly growing literature as a lot of studies were published focusing on how to incorporate environmental issues into supplier evaluation. This paper contributes to this stream of research as it develops a method to help weight selection. In the authors’ paper the method of Data Envelope Analysis (DEA) is used to study the extension of traditional supplier selection methods with environmental factors. The selection of the weight system can control the result of the selection process.

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A tanul¡ny - amely Coase és az új intéz©nyi közgazdaságtan alapján keresi a címbeli kérdésre adható választ - a kapitalizmus alapvetÅ‘ interakciós for¡jaként a kölcsönösen elÅ‘nyös cserét azonosítja, amely az emberi együtt±ködés megnyilvánulása. A gazdasági fejlÅ‘dés feltétele e kooperáció költségeit csökkentÅ‘ társadalmi játékszabályok, intéz©nyek kialakítása. A jól ±ködÅ‘ kapitalizmus intéz©nyi rendje sűrű és sokrétű, a részleteit tekintve idÅ‘ben és térben igen változó, jelentÅ‘s részben nem állami, hanem magáneredetű. Ez a rend nem tervezhetÅ‘ meg, és jelenlegi tudásunk alapján nem is érthetÅ‘ meg konzisztens, összefüggÅ‘ rendszerként. A magyar gazdaság fejlÅ‘dési célját ezért nem lehet nemzetgazdasági szintű rendszerként vagy modellként megfogalmazni. A tényleges feladat az intéz©nyi rend középszintű elemeinek fokozatos, kísérletezÅ‘ változtatása, figyelembe véve a ¡r létezÅ‘ intéz©nyi környezet történetileg adott, helyhez és idÅ‘höz kötött sajátosságait. De az intéz©nyi "barkácsolásnak" mindvégig szem elÅ‘tt kell tartania a kapitalizmus alapelvét: az önkéntes, kölcsönösen elÅ‘nyös tranzakciók támogatását. _____ The study draws on Coase s lighthouse" of new institutional economics in addressing this question. It identifies mutually beneficial exchange, a manifestation of human cooperation, as the underlying form of interaction in capitalism, while stressing that economic development depends on creating social rules of the game (institutions) that decrease the costs of exchange. The institutional order of well-functioning capitalism is thickly woven with many features, often of private rather than public (legal or political) origin. Details vary greatly in time and space. Such an order cannot be planned, and with current knowledge, it cannot be seen as a consistent system. So the goal in Hungary s economic development should not be defined as a system or model for a national economy. It should set out to change intermediate-level institutions in gradual, experimental ways that pay heed to the time and space-bound idiosyncrasies of existing ones. Moreover institutional tinkering" should observe capitalism s basic institutional principle: facilitation of voluntary, mutually beneficial transactions.

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The chemical composition of surface associated metabolites of two Fucus species (Fucus vesiculosus and Fucus serratus) was analysed by means of gas chromatography-mass spectrometry (GC-MS) to describe temporal patterns in chemical surface composition. Method: The two perennial brown macroalgae F. vesiculosus and F. serratus were sampled monthly at Bülk, outer Kiel Fjord, Germany (54°27'21 N / 10°11'57 E) over an entire year (August 2012 - July 2013). Per month and species six non-fertile Fucus individuals were collected from mixed stands at a depth of 0.5 m under mid water level. For surface extraction approx. 50 g of the upper 5-10 cm apical thalli tips were cut off per species. The surface extraction of Fucus was performed according to the protocol of de Nys and co-workers (1998) with minor modifications (see Rickert et al. 2015). GC/EI-MS measurements were performed with a Waters GCT premier (Waters, Manchester, UK) coupled to an Agilent 6890N GC equipped with a DB-5 ms 30 m column (0.25 mm internal diameter, 0.25 mM film thickness, Agilent, USA). The inlet temperature was maintained at 250°C and samples were injected in split 10 mode. He carrier gas flow was adjusted to 1 ml min-1. Alkanes were used for referencing of retention times. For further details (GC-MS sample preparation and analysis) see the related publication (Rickert et al. submitted to PLOS ONE).

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Pollen analysis of Wisconsinan sediments from eleven localities in northern and central Illinois, combined with the results of older studies, allows a first general survey of the vegetational changes in Illinois during the last glaciation. In the late Altonian (after 40,000 B.P.), pine was already the most prevalent tree type in northern Illinois. Probably because of the influence of the last Altonian ice advance to northern Illinois, pine migrated to the south and reached south-central Illinois, which was at that time a region of prairie, with oak and hickory trees in favorable sites. Likewise in the late Altonian, spruce appeared in northern Illinois. Spruce also expanded its area to the south during the Wisconsinan, reaching south-central Illinois only after 21,000 B.P., in the early Woodfordian. Deciduous trees (predominantly oak) were present in south-central Illinois throughout the Wisconsinan. Their prevalence decreased to the north. The vegetation during the different subdivisions of the last glacial period in Illinois was approximately as follows: Late Altonian: Pine/spruce forest with some deciduous trees in northern and central Illinois; prairie and oak/hickory stands in south-central Illinois; immigration of pine. Farmdalian: Pine/spruce forest in central Illinois; deciduous trees and pine in south-central Illinois, with areas of open vegetation, perhaps similar to the present-day transition of prairie to forest in the northern Great Plains. Woodfordian: Northern and central Illinois ice covered; in south central Illinois, spruce and oak as dominant tree types, but also pine and grassland. During the Woodfordian, pine and spruce disappeared again from south-central Illinois, and oak/hickory forest and prairie again prevailed. The ice-free areas of northern Illinois become populated temporarily with spruce, but later there is proof of deciduous forest in this region. Pollen investigations in south-central Illinois have shown convincingly that deciduous trees could survive relatively close (less than 60 km) to the ice margin. Therefore the frequently presented view that arctic climatic conditions prevailed in North America during the last glaciation far south of the ice margin can be refuted for the Illinois area, confirming the opinion of other authors resulting from investigations of fossil mollusks and frost-soil features. The small number of localities investigated still permits no complete reconstruction of the vegetation zones and their possible movements in Illinois. During the Altonian and Farmdalian in Illinois, a vegetational zonation probably existed similar to that of today in North America. As the ice pushed southward as far as 39° 20' N. lat in the early Woodfordian, this zonation was apparently broken up under the influence of a relatively moderate climate. In any case, the Vandalia area, which was only about 60 km south of the ice, was at that time neither in a tundra zone nor in a zone of boreal coniferous forest.

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Im Mittelpunkt dieser Tagungspublikation stehen zwei Kernfragen: Erstens: Welche Interessengruppen stellen welche Anforderungen an die Qualitätssicherung? Diese Frage führt zur Diskussion über den Zweck, den unterschiedliche Interessengruppen mit der Qualitätssicherung verfolgen. Die zweite wichtige Kernfrage betrifft die Wirkungen von Qualitätssicherung. Bewirken sie tatsächlich ein Mehr an Qualität oder dienen sie lediglich der Erfüllung von Berichtspflichten? Und damit eng zusammenhängend: Was sind die intendierten, was die nicht intendierten Effekte von Qualitätssicherung? Die Sicht verschiedener politischer Entscheidungsträgerinnen und -träger, die Sicht der Studierenden und die Sicht der Qualitätssicherungsagentur über die Anforderungen und Wirkungen von Qualitätssicherung werden dargestellt. Ebenso beleuchten Beiträge von Repräsentantinnen und Repräsentanten der Hochschulsektoren die beiden Kernfragen. Die Beiträge zeigen, wo gemeinsame und wo unterschiedliche Interessen bestehen. Mit Beiträgen von: Burckhart, Holger; Hanft, Anke; Hopbach, Achim; Töchterle, Karlheinz; Kazoka, Asnate; Badelt, Christoph; Eckl, Martha; Wulz, Janine; Mann, Susanne; Feucht, Gudrun; Brandstätter, Wilhelm; Moser, Josef-Anton; Treml, Beate; Kainz, Harald; Gaberscik, Gerald; Fink, Kerstin; Wöber, Karl.

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Background: Several materials have been used for tissue engineering purposes, since the ideal matrix depends on the desired tissue. Silk biomaterials have come to focus due to their great mechanical properties. As untreated silkworm silk has been found to be quite immunogenic, an alternative could be spider silk. Not only does it own unique mechanical properties, its biocompatibility has been shown already in vivo. In our study, we used native spider dragline silk which is known as the strongest fibre in nature. Methodology/Principal Findings: Steel frames were originally designed and manufactured and woven with spider silk, harvesting dragline silk directly out of the animal. After sterilization, scaffolds were seeded with fibroblasts to analyse cell proliferation and adhesion. Analysis of cell morphology and actin filament alignment clearly revealed adherence. Proliferation was measured by cell count as well as determination of relative fluorescence each after 1, 2, 3, and 5 days. Cell counts for native spider silk were also compared with those for trypsin-digested spider silk. Spider silk specimens displayed less proliferation than collagen-and fibronectin-coated cover slips, enzymatic treatment reduced adhesion and proliferation rates tendentially though not significantly. Nevertheless, proliferation could be proven with high significance (p<0.01). Conclusion/Significance: Native spider silk does not require any modification to its application as a biomaterial that can rival any artificial material in terms of cell growth promoting properties. We could show adhesion mechanics on intracellular level. Additionally, proliferation kinetics were higher than in enzymatically digested controls, indicating that spider silk does not require modification. Recent findings concerning reduction of cell proliferation after exposure could not be met. As biotechnological production of the hierarchical composition of native spider silk fibres is still a challenge, our study has a pioneer role in researching cellular mechanics on native spider silk fibres.

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Wenn pädagogische Institutionen u.a. über ihren Auftrag definiert werden, ¶glichst erfolgreiche Lern- und Bildungsprozesse ihrer Zielgruppe zu organisieren (und in diesem Sinne Leistung zu produzieren haben), so bedeuten Diagnosen einer Abhängigkeit der Leistung von der Geschlechtszugehörigkeit eine empfindliche Infragestellung der Qualität der Institution. Schule als pädagogische Institution kategorisiert Schüler_innen entlang der Lernerfolge und Leistungen, die sie erbringen. Seit durch die Ergebnisse internationaler Schulleistungsvergleiche die Kategorisierungen von Schüler_innen als leistungsstärker bzw. -schwächer wieder verstärkt mit ihrer Kategorisierung als ¤dchen und Jungen in Zusammenhang gebracht werden, scheint es nahe zu liegen, geringere Schulerfolge von Jungen pauschalisierend mit ihrem Junge-Sein an sich in Verbindung zu bringen. Hier interveniert der Beitrag der AutorInnen zum Zusammenhang von ¤nnlichkeitskonstruktionen mit der Lern- und Leistungsmotivation bei Jungen. Der Artikel stellt das Freiburger Jungeninventar vor, ein Instrument, das auf der Basis qualitativer Rekonstruktionen differenzierbarer ¤nnlichkeiten entwickelt wurde und diese nun auch quantitativ und in Kombination mit anderen Variablen erfassbar macht. In ihrer Studie, in der das Freiburger Jungeninventar in Verbindung mit Instrumenten zur Erfassung von Lern- und Leistungsmotivation zum Einsatz kommt, zeigen die Autor_innen Zusammenhänge auf, die die Bedeutung der Vielfältigkeit von ¤nnlichkeitskonstruktionen für schulisch institutionalisiertes Lernen unterstreicht. (DIPF/Orig.)

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To this paper we discuss that the phase readout in low noise laser interferometers can significantly deviate from the underlying optical pathlength difference (OPD). The cross coupling of beam tilt to the interferometric phase readout is compared to the OPD. For such a system it is shown that the amount of tilt to phase readout coupling depends strongly on the involved beams and their parameters, as well as on the detector properties and the precise definition of the phase. The unique single element photodiode phase is therefore compared to three common phase definitions for quadrant diodes. It is shown that neither phase definition globally shows the least amount of cross coupling of angular it

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Im Rahmen des BMBF-Leitprojektes „Virtuelle Fachhochschule“ werden in einem interdisziplinären Team an der TFH Berlin 12 Online-Studienmodule für die Bachelor-Studiengänge Medieninformatik und Wirtschaftsingenieurwesen produziert. Unter der Leitung langjährig in der Lehre erfahrener Professorinnen und Professoren wurden mediendidaktisch anspruchsvolle Online-Kurse entwickelt. Das didaktische Design war neben der Produktentwicklung konsequent auf die Entwicklung eines effizienten Produktionsprozesses für multimediales Lernmaterial ausgerichtet. Das Online-Lernmaterial ist so modular aufgebaut, dass Teile daraus in die Präsenzlehre integrierbar sind. Der mehrstufige, abgestimmte Produktionsprozess kann für die kostengünstige Erstellung von Online-Material in anderen Fächern genutzt werden. Das Verfahren ist darüber hinaus erweiterbar. Diese Entwicklung leistet einen Beitrag zur nachhaltigen Integration von Online- Lehr- und Lernangeboten im Hochschulbereich.(DIPF/Orig.)

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Introduction: Female sex is predictive of poor functional outcome in stroke, even after correction for prognostic factors. Poor quality of life (QoL) is observed in stroke survivors, with lower scores seen in the most disabled patients. We used data from the TAIST trial to assess the relationship between sex and QoL after ischaemic stroke. Methods: TAIST was a randomised controlled trial assessing the safety and efficacy of tinzaparin versus aspirin in 1,484 patients with acute ischaemic stroke. QoL was measured at 180 days post randomisation using the short-form 36 health survey which assesses QoL across eight domains. The relationship between sex and each domain was assessed using ordinal regression, both unadjusted and adjusted for key prognostics factors. Results: Of the 1,484 patients randomised into TAIST, 216 had died at 180 days post randomisation. 1,268 survivors were included in this analysis, 694 males (55%), 574 females (45%). Females tended to score lower than males across all QoL domains (apart from general health); statistically significant lower scores were seen for physical functioning (odds ratio (OR) 0.58, 95% confidence interval (CI) 0.47-0.72), vitality (OR 0.79, 95% CI 0.64-0.98) and mental health (OR 0.75, 95% CI 0.61-0.93). The results for physical functioning and mental health remained significant after adjustment for prognostic variables (OR 0.73, 95% CI 0.58-0.92; OR 0.76, 95% CI 0.60-0.95 respectively). Conclusions: QoL, in particular physical function and mental health domains, is lower in female patients after stroke. This difference persists even after correction for known prognostic factors such as age and stroke severity.

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Introduction: Baseline severity and clinical stroke syndrome (Oxford Community Stroke Project, OCSP) classification are predictors of outcome in stroke. We used data from the ‘Tinzaparin in Acute Ischaemic Stroke Trial’ (TAIST) to assess the relationship between stroke severity, early recovery, outcome and OCSP syndrome. Methods: TAIST was a randomised controlled trial assessing the safety and efficacy of tinzaparin versus aspirin in 1,484 patients with acute ischaemic stroke. Severity was measured as the Scandinavian Neurological Stroke Scale (SNSS) at baseline and days 4, 7 and 10, and baseline OCSP clinical classification recorded: total anterior circulation infarct (TACI), partial anterior circulation infarct (PACI), lacunar infarct (LACI) and posterior circulation infarction (POCI). Recovery was calculated as change in SNSS from baseline at day 4 and 10. The relationship between stroke syndrome and SNSS at days 4 and 10, and outcome (modified Rankin scale at 90 days) were assessed. Results: Stroke severity was significantly different between TACI (most severe) and LACI (mildest) at all four time points (p<0.001), with no difference between PACI and POCI. The largest change in SNSS score occurred between baseline and day 4; improvement was least in TACI (median 2 units), compared to other groups (median 3 units) (p<0.001). If SNSS did not improve by day 4, then early recovery and late functional outcome tended to be limited irrespective of clinical syndrome (SNSS, baseline: 31, day 10: 32; mRS, day 90: 4); patients who recovered early tended to continue to improve and had better functional outcome irrespective of syndrome (SNSS, baseline: 35, day 10: 50; mRS, day 90: 2). Conclusions: Although functional outcome is related to baseline clinical syndrome (best with LACI, worst with TACI), patients who improve early have a more favourable functional outcome, irrespective of their OCSP syndrome. Hence, patients with a TACI syndrome may still achieve a reasonable outcome if early recovery occurs.

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Background: Venous thromboembolism (VTE) is a well recognised and preventable complication of acute stroke. While graduated compression stockings reduce the risk of VTE in surgical patients their benefit in acute stroke remains uncertain. Methods: The relationship between symptomatic VTE and use of stockings using observational data from the ‘Tinzaparin in Acute Ischaemic Stroke Trial’, which compared 10 days of treatment with tinzaparin (175 IU.kg-1 or 100 IU.kg-1) with, aspirin (300 mg od), was assessed using logistic regression adjusted for known VTE risk factors and treatment. Results: Symptomatic VTE occurred in 28 patients (1.9%, DVT 18, PE 13) within 15 days of enrolment in 1,479 patients. Patients wearing one or two stockings for any period of time during the first 10 days (n=803) had a non-significant increase (odds ratio, OR 2.45, 95% confidence interval, CI 0.95 - 6.32) in the risk of symptomatic VTE. In contrast, those wearing bilateral stockings for 10 days (n=374) had a non-significant reduction in the odds of symptomatic VTE as compared to those who wore no stockings or wore them for less than 10 days (OR 0.65, 95% CI 0.26-1.65). Mild stroke and treatment with tinzaparin were associated with a reduced risk of VTE. Conclusions: Bilateral graduated compression stockings may reduce the incidence of VTE by one-third in patients with acute ischaemic stroke. However, the uncertainty in this finding, low frequency of symptomatic VTE, potential for stockings to cause harm, and cost of stockings highlight the need for a large randomised-controlled trial to examine the safety and efficacy of stockings in acute stroke.