The novels and tales of Robert Louis Stevenson /

"Index to the Thistle edition, comp. by F. D. Tandy": vol. 22, p. 645-669.

The novels and tales of Robert Louis Stevenson ...

Criticisms, etc.--XXIII-XXIV. Letters to his family and friends, selected and ed. ... by S. Colvin.--XXV-XXVI. The life of Robert Louis Stevenson, by G. Balfour.--XXVII. New letters, selected and ed. by S. Colvin.

The cruise of the "Janet Nichol" among the South Sea Islands; a diary of Mrs. Robert Louis Stevenson.

Mode of access: Internet.

Lucelle, tragicomedie en prose francaise von Louis le Jars (1576) und Lucelle, tragicomedie mise en vers francais von Jacques Duhamel (1607) nebst einem Anhang De l'Art de la Tragedie von Jean de la Taille.

Thesis (doctoral)--Universitat Greifswald.

The life of Robert Louis Stevenson.

Mode of access: Internet.

The faith of Robert Louis Stevenson /

Includes index.

Oeuvres choisies de Balzac, precedees d'une notice / Balzac, Jean Louis Guez, sieur de, d. 1654.

Mode of access: Internet.

Through a Literary Lens: The Effect of Jean Paul and E.T.A. Hoffmann’s Writing Styles on the Compositional Techniques of Robert Schumann

Thesis (D.M.A.)--University of Washington, 2016-06

Crisis de la experiencia : ¿imposibilidad o reconfiguración? Benjamin a través de Jean-Louis Déotte

Fil: Staroselsky, Tatiana. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

Crisis de la experiencia : ¿imposibilidad o reconfiguración? Benjamin a través de Jean-Louis Déotte

Fil: Staroselsky, Tatiana. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

Crisis de la experiencia : ¿imposibilidad o reconfiguración? Benjamin a través de Jean-Louis Déotte

Fil: Staroselsky, Tatiana. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

Meta-analysis of individual patient data from randomized trials of chemotherapy plus cetuximab as first-line treatment for advanced non-small cell lung cancer

OBJECTIVES: Four randomized phase II/III trials investigated the addition of cetuximab to platinum-based, first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). A meta-analysis was performed to examine the benefit/risk ratio for the addition of cetuximab to chemotherapy. MATERIALS AND METHODS: The meta-analysis included individual patient efficacy data from 2018 patients and individual patient safety data from 1970 patients comprising respectively the combined intention-to-treat and safety populations of the four trials. The effect of adding cetuximab to chemotherapy was measured by hazard ratios (HRs) obtained using a Cox proportional hazards model and odds ratios calculated by logistic regression. Survival rates at 1 year were calculated. All applied models were stratified by trial. Tests on heterogeneity of treatment effects across the trials and sensitivity analyses were performed for all endpoints. RESULTS: The meta-analysis demonstrated that the addition of cetuximab to chemotherapy significantly improved overall survival (HR 0.88, p=0.009, median 10.3 vs 9.4 months), progression-free survival (HR 0.90, p=0.045, median 4.7 vs 4.5 months) and response (odds ratio 1.46, p<0.001, overall response rate 32.2% vs 24.4%) compared with chemotherapy alone. The safety profile of chemotherapy plus cetuximab in the meta-analysis population was confirmed as manageable. Neither trials nor patient subgroups defined by key baseline characteristics showed significant heterogeneity for any endpoint. CONCLUSION: The addition of cetuximab to platinum-based, first-line chemotherapy for advanced NSCLC significantly improved outcome for all efficacy endpoints with an acceptable safety profile, indicating a favorable benefit/risk ratio.

New genetic loci link adipose and insulin biology to body fat distribution

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10−8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.