Career adaptability development in adolescence: Multiple prdictors and effect on sense of power and life satisfaction

This longitudinal panel study investigated predictors of career adaptability development and its effect on development of sense of power and experience of life satisfaction among 330 Swiss eighth graders. A multivariate measure of career adaptability consisting of career choice readiness, planning, exploration, and confidence was applied. Based on Motivational Systems Theory four groups of predictors were assessed: positive emotional disposition, goal decidedness, capability beliefs and social context beliefs. Influence of gender, age, immigration background, parental educational level, and college-bound or vocational education plans were also assessed. Perceived social support and positive emotional disposition, non-immigration background, and continuing to vocational education were single significant predictors of more career adaptability development over the school year. Supporting the connection of career adaptability and positive youth development, increase in career adaptability over time predicted increase in sense of power and experience of life satisfaction.

To sense or not to sense viral RNA--essentials of coronavirus innate immune evasion.

An essential function of innate immunity is to distinguish self from non-self and receptors have evolved to specifically recognize viral components and initiate the expression of antiviral proteins to restrict viral replication. Coronaviruses are RNA viruses that replicate in the host cytoplasm and evade innate immune sensing in most cell types, either passively by hiding their viral signatures and limiting exposure to sensors or actively, by encoding viral antagonists to counteract the effects of interferons. Since many cytoplasmic viruses exploit similar mechanisms of innate immune evasion, mechanistic insight into the direct interplay between viral RNA, viral RNA-processing enzymes, cellular sensors and antiviral proteins will be highly relevant to develop novel antiviral targets and to restrict important animal and human infections.

Two distinct filopodia populations at the growth cone allow to sense nanotopographical extracellular matrix cues to guide neurite outgrowth

BACKGROUND The process of neurite outgrowth is the initial step in producing the neuronal processes that wire the brain. Current models about neurite outgrowth have been derived from classic two-dimensional (2D) cell culture systems, which do not recapitulate the topographical cues that are present in the extracellular matrix (ECM) in vivo. Here, we explore how ECM nanotopography influences neurite outgrowth. METHODOLOGY/PRINCIPAL FINDINGS We show that, when the ECM protein laminin is presented on a line pattern with nanometric size features, it leads to orientation of neurite outgrowth along the line pattern. This is also coupled with a robust increase in neurite length. The sensing mechanism that allows neurite orientation occurs through a highly stereotypical growth cone behavior involving two filopodia populations. Non-aligned filopodia on the distal part of the growth cone scan the pattern in a lateral back and forth motion and are highly unstable. Filopodia at the growth cone tip align with the line substrate, are stabilized by an F-actin rich cytoskeleton and enable steady neurite extension. This stabilization event most likely occurs by integration of signals emanating from non-aligned and aligned filopodia which sense different extent of adhesion surface on the line pattern. In contrast, on the 2D substrate only unstable filopodia are observed at the growth cone, leading to frequent neurite collapse events and less efficient outgrowth. CONCLUSIONS/SIGNIFICANCE We propose that a constant crosstalk between both filopodia populations allows stochastic sensing of nanotopographical ECM cues, leading to oriented and steady neurite outgrowth. Our work provides insight in how neuronal growth cones can sense geometric ECM cues. This has not been accessible previously using routine 2D culture systems.

Conventionalism and the World as Bare Sense-Data

We are confident of many of the judgements we make as to what sorts of alterations the members of nature’s kinds can survive, and what sorts of events mark the ends of their existences. But is our confidence based on empirical observation of nature’s kinds and their members? Conventionalists deny that we can learn empirically which properties are essential to the members of nature’s kinds. Judgements of sameness in kind between members, and of numerical sameness of a member across time, merely project our conventions of individuation. Our confidence is warranted because apart from those conventions there are no phenomena of kind-sameness or of numerical sameness across time. There is just “stuff” displaying properties. This paper argues that conventionalists can assign no properties to the “stuff” beyond immediate phenomenal properties. Consequently they cannot explain how each of us comes to be able to wield “our conventions”.

Ein Symposium der Forschung [Rezension] : Occident and Orient. Being Studies in Semitic Philology and Literature, Jewish History, Philosophy and Folklore in the widest sense. In Honour of Haham Dr. Gasters 80. Birthday ed. by Bruno Schindler and A. Marmorstein. Taylors Foreign Press, London 1937

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Instituciones y cultura política : un ensayo sobre dificultades de la democracia argentina

Pasados veinte años de la reinstalación de la democracia, se hace una reflexión de los sentidos que la democracia ha tenido en la historia argentina. La analogía con pacto civilizatorio, en el sentido freudiano de reconocimiento de la ley, es un punto de partida metafórico para observar cómo a través del tiempo el pacto originario sufrió no sólo cambios en su significación, sino quiebres y rupturas que condujeron a estados de violencia cada vez más profundos, rompiendo con las formas de convivencia ciudadana. La focalización del último período democrático pondera a través del relato de los procesos políticos, no sólo las expectativas y desilusiones ciudadanas, sino los avances y limitaciones institucionales de los últimos veinte años.

Zangorromangos, bimbilindrones, chuchumbés y otros eufemismos líricos populare

Dentro de las composiciones de extracción oral y popular se destaca la utilización de algunas palabras que entrañan una enorme significación. Se trata de estribillos que funcionan como una especie de muletilla expresiva, rítmica y metafórica, aunque el sentido oculto al que remiten resulte un tanto misterioso. Estos artilugios estilísticos, a mitad de camino entre la onomatopeya, el juego de palabras e ironías y el comodín rítmico y métrico, contienen muchas veces, un doble sentido insinuante que conlleva denotaciones pícaras y sensuales, atrevidas, procaces y a veces escandalosas. Este repertorio poético, antes desatendido, persiste no como reflejo pasivo de tradiciones heredadas, sino como crisol vivo de nuevas recreaciones y reconfiguraciones que impregnan géneros, repertorios y diversos registros

Zangorromangos, bimbilindrones, chuchumbés y otros eufemismos líricos populare

Dentro de las composiciones de extracción oral y popular se destaca la utilización de algunas palabras que entrañan una enorme significación. Se trata de estribillos que funcionan como una especie de muletilla expresiva, rítmica y metafórica, aunque el sentido oculto al que remiten resulte un tanto misterioso. Estos artilugios estilísticos, a mitad de camino entre la onomatopeya, el juego de palabras e ironías y el comodín rítmico y métrico, contienen muchas veces, un doble sentido insinuante que conlleva denotaciones pícaras y sensuales, atrevidas, procaces y a veces escandalosas. Este repertorio poético, antes desatendido, persiste no como reflejo pasivo de tradiciones heredadas, sino como crisol vivo de nuevas recreaciones y reconfiguraciones que impregnan géneros, repertorios y diversos registros

Zangorromangos, bimbilindrones, chuchumbés y otros eufemismos líricos populare

Dentro de las composiciones de extracción oral y popular se destaca la utilización de algunas palabras que entrañan una enorme significación. Se trata de estribillos que funcionan como una especie de muletilla expresiva, rítmica y metafórica, aunque el sentido oculto al que remiten resulte un tanto misterioso. Estos artilugios estilísticos, a mitad de camino entre la onomatopeya, el juego de palabras e ironías y el comodín rítmico y métrico, contienen muchas veces, un doble sentido insinuante que conlleva denotaciones pícaras y sensuales, atrevidas, procaces y a veces escandalosas. Este repertorio poético, antes desatendido, persiste no como reflejo pasivo de tradiciones heredadas, sino como crisol vivo de nuevas recreaciones y reconfiguraciones que impregnan géneros, repertorios y diversos registros

Revisiting the Classics to recover the Physical Sense in electrical noise

This paper shows a physically cogent model for electrical noise in resistors that has been obtained from Thermodynamical reasons. This new model derived from the works of Johnson and Nyquist also agrees with the Quantum model for noisy systems handled by Callen and Welton in 1951, thus unifying these two Physical viewpoints. This new model is a Complex or 2-D noise model based on an Admittance that considers both Fluctuation and Dissipation of electrical energy to excel the Real or 1-D model in use that only considers Dissipation. By the two orthogonal currents linked with a common voltage noise by an Admittance function, the new model is shown in frequency domain. Its use in time domain allows to see the pitfall behind a paradox of Statistical Mechanics about systems considered as energy-conserving and deterministic on the microscale that are dissipative and unpredictable on the macroscale and also shows how to use properly the Fluctuation-Dissipation Theorem.

Recitado en duo, en que sense solfes es pondèra algo de la vida, y miracles de Sant Pere Pasqual de València, en les festes que es fan ... per el arribo de la seua Santa Reliquia [-primera part]

Las fiestas de la llegada de la reliquia de san Pedro Pascual fueron en octubre de 1743