Multiple myeloma-associated amyloidoma of the sacrum: case report and review of the literature.

Study Design Case report. Objectives With only two previously reported cases, localized amyloidosis of the sacrum is extremely rare. Here we report a 64-year-old woman with a large osteolytic lesion accompanied by weakness and paresthesia of the right leg and difficulties in bladder control. Methods Fine needle biopsy and standard staging procedures revealed a primary solitary amyloidoma that was treated with intralesional resection, lumbopelvic stabilization, and consolidation radiotherapy. Results Clinical follow-up revealed the diagnosis of multiple myeloma 9 months after initial treatment. At 12 months, no local recurrence has occurred, the neurologic symptoms have resolved, and the systemic disease is in remission. Conclusions Intralesional resection with adjuvant radiotherapy of the amyloidoma achieved good local tumor control with limited morbidity.

The Kabbalah : its doctrines, development and literature : (repr. verbatim from the first ed. which cont. pp. 1-82 entitles "The Essenes")

by Christian D. Ginsburg

A short survey of the literature of rabbinical and mediaeval Judaism

by W. O. E. Oesterley and G. H. Box

Epstein-barr virus in gastro-esophageal adenocarcinomas - single center experiences in the context of current literature.

Epstein-Barr virus (EBV)-associated gastric carcinomas (GC) represent a distinct and well-recognized subtype of gastric cancer with a prevalence of around 10% of all GC. In contrast, EBV has not been reported to play a major role in esophageal adenocarcinomas (EAC) and adenocarcinomas of the gastro-esophageal junction (GEJ). We report our experiences on EBV in collections of gastro-esophageal adenocarcinomas from two surgical centers and discuss the current state of research in this field. Tumor samples from 465 primary resected gastro-esophageal adenocarcinomas (118 EAC, 73 GEJ, and 274 GC) were investigated. Presence of EBV was determined by EBV-encoded small RNAs (EBER) in situ hybridization. Results were correlated with pathologic parameters (UICC pTNM category, Her2 status, tumor grading) and survival. EBER positivity was observed in 14 cases. None of the EAC were positive for EBER. In contrast, we observed EBER positivity in 2/73 adenocarcinomas of the GEJ (2.7%) and 12/274 GC (4.4%). These were of intestinal type (seven cases) or unclassifiable (six cases), while only one case was of diffuse type according to the Lauren classification. No association between EBV and pT, pN, or tumor grading was found, neither was there a correlation with clinical outcome. None of the EBER positive cases were Her2 positive. In conclusion, EBV does not seem to play a role in the carcinogenesis of EAC. Moreover, adenocarcinomas of the GEJ show lower rates of EBV positivity compared to GC. Our data only partially correlate with previous reports from the literature. This highlights the need for further research on this distinct entity. Recent reports, however, have identified specific epigenetic and genetic alterations in EBV-associated GC, which might lead to a distinct treatment approach for this specific subtype of GC in the future.

The Five Senses in Medieval and Early Modern England

Edited by Annette Kern-Stähler, Beatrix Busse, and Wietse de Boer The essays collected in The Five Senses in Medieval and Early Modern England examine the interrelationships between sense perception and secular and Christian cultures in England from the medieval into the early modern periods. They address canonical texts and writers in the fields of poetry, drama, homiletics, martyrology and early scientific writing, and they espouse methods associated with the fields of corpus linguistics, disability studies, translation studies, art history and archaeology, as well as approaches derived from traditional literary studies. Together, these papers constitute a major contribution to the growing field of sensorial research that will be of interest to historians of perception and cognition as well as to historians with more generalist interests in medieval and early modern England.

New Clinical Indications for (18)F/(11)C-choline, New Tracers for Positron Emission Tomography and a Promising Hybrid Device for Prostate Cancer Staging: A Systematic Review of the Literature

CONTEXT Radiolabelled choline positron emission tomography has changed the management of prostate cancer patients. However, new emerging radiopharmaceutical agents, like radiolabelled prostate specific membrane antigen, and new promising hybrid imaging will begin new challenges in the diagnostic field. OBJECTIVE The continuous evolution in nuclear medicine has led to the improvement in the detection of recurrent prostate cancer (PCa), particularly distant metastases. New horizons have been opened for radiolabelled choline positron emission tomography (PET)/computed tomography (CT) as a guide for salvage therapy or for the assessment of systemic therapies. In addition, new tracers and imaging tools have been recently tested, providing important information for the management of PCa patients. Herein we discuss: (1) the available evidence in literature on radiolabelled choline PET and their recent indications, (2) the role of alternative radiopharmaceutical agents, and (3) the advantages of a recent hybrid imaging device (PET/magnetic resonance imaging) in PCa. EVIDENCE ACQUISITION Data from recently published (2010-2015), original articles concerning the role of choline PET/CT, new emerging radiotracers, and a new imaging device are analysed. This review is reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. EVIDENCE SYNTHESIS In the restaging phase, the detection rate of choline PET varies between 4% and 97%, mainly depending on the site of recurrence and prostate-specific antigen levels. Both 68gallium (68Ga)-prostate specific membrane antigen and 18F-fluciclovine are shown to be more accurate in the detection of recurrent disease as compared with radiolabelled choline PET/CT. Particularly, Ga68-PSMA has a detection rate of 50% and 68%, respectively for prostate-specific antigen levels < 0.5ng/ml and 0.5-2ng/ml. Moreover, 68Ga- PSMA PET/magnetic resonance imaging demonstrated a particularly higher accuracy in detecting PCa than PET/CT. New tracers, such as radiolabelled bombesin or urokinase-type plasminogen activator receptor, are promising, but few data in clinical practice are available today. CONCLUSIONS Some limitations emerge from the published papers, both for radiolabelled choline PET/CT and also for new radiopharmaceutical agents. Efforts are still needed to enhance the impact of published data in the world of oncology, in particular when new radiopharmaceuticals are introduced into the clinical arena. PATIENT SUMMARY In the present review, the authors summarise the last evidences in clinical practice for the assessment of prostate cancer, by using nuclear medicine modalities, like positron emission tomography/computed tomography and positron emission tomography/magnetic resonance imaging.

My first twenty chapters of the Mahawanso and prefatory essay on Pali buddhistical literature, originally published as an introduction to the above mentioned portion of the Mahawanso

by George Turnour

Del “Dios presente" al “Ser omnipotente" : la helenización de Yahweh en el cristianismo medieval

El judaísmo tardío y posteriormente el cristianismo incursionaron frecuentemente en el célebre pasaje de Éx. 3, 14, entendiéndolo como la revelación del Nombre divino a Moisés. Las respectivas influencias de la ontología griega y de la Septuaginta que traduce el citado texto hebreo por “Yo Soy el que Soy" (ejgwv eijmi oJ w[n), se hicieron presentes en la tradición cristiana desde sus orígenes hasta la Escolástica del siglo XIII. Sea con matices esencialistas o de carácter existencial, el Dios bíblico ha sido comprendido como “Ser" en distintos momentos del cristianismo medieval. Este alejamiento de la intuición bíblica originaria en dirección a una concepción helénica del Ser, produjo notables consecuencias en la imagen de Dios sostenida por los cristianos.

Bestiarios medievales e imaginario social

Los historiadores medievalistas se concentran, en la actualidad, en descubrir y penetrar el sistema de valores, creencias y sentimientos de hombres y mujeres de aquella época, cómo se representaban el mundo y el espíritu de una sociedad para la cual lo invisible merecía tanto interés como lo visible. Los Bestiarios fueron considerados en su época libros de historia natural y sus autores pretendieron darles características científicas, pero al dotarlos de un tono moralizante, acudir a las leyendas y apelar a los animales más inverosímiles y fantásticos concebidos por el hombre medieval, pasaron a formar parte «de aquel dominio de lo maravilloso donde se expresa el imaginario de una época». Por consiguiente, al recurrir a la alegoría como procedimiento expresivo privilegiado y procurar educar las conciencias en las reglas de la ecumenidad cristiana, de ser pretendidos textos científicos se convirtieron en una de las más sorprendentes páginas de la literatura medieval. En ellos pesa más la valoración alegórica de las criaturas descriptas que la veracidad de las descripciones. La literatura didáctica fue uno de los mecanismos que se emplearon para lograr la adhesión al ideal cristiano. Los autores de los Bestiarios describían las bestias y usaban esa descripción como base de una enseñanza alegórica. De este modo, al mismo tiempo que algunos animales representaron a Cristo, otros simbolizaron el Mal o se convirtieron en proyección de los vicios y defectos humanos. Este trabajo se propone analizar la representación literaria de algunos de estos animales como expresión del imaginario de una época.

Cultura popular y poesía narrativa medieval: contactos productivos

El presente artículo propone focalizar la pertinencia de la configuración teórica del concepto de literatura y cultura popular para el estudio de la poesía narrativa medieval en su pasaje del universo de la oralidad al de la escritura, y de la escritura manuscrita a la imprenta. Los ejemplos serán aportados a su vez por los géneros narrativos paradigmáticos medievales, la épica y el romancero, en el dominio lingüístico específico del castellano.

Cultura popular y poesía narrativa medieval: contactos productivos

El presente artículo propone focalizar la pertinencia de la configuración teórica del concepto de literatura y cultura popular para el estudio de la poesía narrativa medieval en su pasaje del universo de la oralidad al de la escritura, y de la escritura manuscrita a la imprenta. Los ejemplos serán aportados a su vez por los géneros narrativos paradigmáticos medievales, la épica y el romancero, en el dominio lingüístico específico del castellano.