Ypres, les halles [i. e. la cathédrale Saint-Martin, ruines] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57805

Première réunion de la ligue des nations à Londres, Albert Thomas et M. [Léon] Bourgeois au Palais St James : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57999

17-1-20, Congrès de Versailles, M. Albert Thomas : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57686

EGASP: the human ENCODE Genome Annotation Assessment Project

Background: We present the results of EGASP, a community experiment to assess the state-ofthe-art in genome annotation within the ENCODE regions, which span 1% of the human genomesequence. The experiment had two major goals: the assessment of the accuracy of computationalmethods to predict protein coding genes; and the overall assessment of the completeness of thecurrent human genome annotations as represented in the ENCODE regions. For thecomputational prediction assessment, eighteen groups contributed gene predictions. Weevaluated these submissions against each other based on a ‘reference set’ of annotationsgenerated as part of the GENCODE project. These annotations were not available to theprediction groups prior to the submission deadline, so that their predictions were blind and anexternal advisory committee could perform a fair assessment.Results: The best methods had at least one gene transcript correctly predicted for close to 70%of the annotated genes. Nevertheless, the multiple transcript accuracy, taking into accountalternative splicing, reached only approximately 40% to 50% accuracy. At the coding nucleotidelevel, the best programs reached an accuracy of 90% in both sensitivity and specificity. Programsrelying on mRNA and protein sequences were the most accurate in reproducing the manuallycurated annotations. Experimental validation shows that only a very small percentage (3.2%) of the selected 221 computationally predicted exons outside of the existing annotation could beverified.Conclusions: This is the first such experiment in human DNA, and we have followed thestandards established in a similar experiment, GASP1, in Drosophila melanogaster. We believe theresults presented here contribute to the value of ongoing large-scale annotation projects and shouldguide further experimental methods when being scaled up to the entire human genome sequence.

Thomas de Capua, Ars dictandi.

Ce ms. a appartenu à l'humaniste Jean Lebègue (1368-1457). Au f. 1, Jean Lebègue a tracé sa signature cryptographique V363713 et au f. 122v son anagramme. A la fin du XVe s., un certain Chefdeville, dont la signature se lit en transparence sur la garde collée du contreplat inf., possédait ce ms. (cf. G. Ouy). Il est ensuite passé dans les collections de la bibliothèque de la cathédrale Notre-Dame de Paris. Au contreplat sup. figure la signature de Claude Joly, chantre de Notre-Dame, suivie de la date "maio 1654" et au f. 1 l'ex-libris "A la bibliotheque de l'Eglise de Paris", précédé de la cote M14 (XVIIe s.). Notre-Dame.

Sernions de Guillaume de Lyon, précédés d'un catalogue des abbés de S. Martin de Tournai.

Fonds non déterminé.