Diseño y desarrollo del backend para la explotación de componentes web empleando Google App Engine

La web vive un proceso de cambio constante, basado en una interacción mayor del usuario. A partir de la actual corriente de paradigmas y tecnologías asociadas a la web 2.0, han surgido una serie de estándares de gran utilidad, que cubre la necesidad de los desarrollos actuales de la red. Entre estos se incluyen los componentes web, etiquetas HTML definidas por el usuario que cubren una función concreta dentro de una página. Existe una necesidad de medir la calidad de dichos desarrollos, para discernir si el concepto de componente web supone un cambio revolucionario en el desarrollo de la web 2.0. Para ello, es necesario realizar una explotación de componentes web, considerada como la medición de calidad basada en métricas y definición de un modelo de interconexión de componentes. La plataforma PicBit surge como respuesta a estas cuestiones. Consiste en una plataforma social de construcción de perfiles basada en estos elementos. Desde la perspectiva del usuario final se trata de una herramienta para crear perfiles y comunidades sociales, mientras que desde una perspectiva académica, la plataforma consiste en un entorno de pruebas o sandbox de componentes web. Para ello, será necesario implementar el extremo servidor de dicha plataforma, enfocado a la labor de explotación, por medio de la definición de una interfaz REST de operaciones y un sistema para la recolección de eventos de usuario en la plataforma. Gracias a esta plataforma se podrán discernir qué parámetros influyen positivamente en la experiencia de uso de un componente, así como descubrir el futuro potencial de este tipo de desarrollos.---ABSTRACT---The web evolves into a more interactive platform. From the actual version of the web, named as web 2.0, many paradigms and standards have arisen. One of those standards is web components, a set of concepts to define new HTML tags that covers a specific function inside a web page. It is necessary to measure the quality of this kind of software development, and the aim behind this approach is to determine if this new set of concepts would survive in the actual web paradigm. To achieve this, it is described a model to analyse components, in the terms of quality measure and interconnection model description. PicBit consists of a social platform to use web components. From the point of view of the final user, this platform is a tool to create social profiles using components, whereas from the point of view of technicians, it consists of a sandbox of web components. Thanks to this platform, we will be able to discover those parameters that have a positive effect in the user experience and to discover the potential of this new set of standards into the web 2.0.

Definición, diseño e implementación de métricas de usuario final sobre componentes web en el lado Front-end, mediante Google Analytics

La web ha evolucionado hacia la participación en la creación de contenido tanto por desarrolladores expertos como por usuarios finales sin un gran conocimiento en esta área. A pesar de que su uso es igual de válido y funcional, las diferencias entre la calidad de los productos desarrollados por ambos puede llegar a ser considerable. Esta característica se observa con mayor claridad cuando se analizan los web components. El trabajo consiste en el desarrollo de un entorno capaz de recoger las métricas de calidad de los componentes, basadas en la interacción con ellos por parte de los usuarios. A partir de las métricas obtenidas, se determinará su calidad para realizar una mejora de la misma, en función de las características valoradas. La selección de las métricas se realiza mediante un estudio de las características que definen a un componente, y permiten ser analizadas. Para poder llevar a cabo la construcción del portal, se ha descrito un prototipo capaz de proporcionar un sistema para permitir que los componentes intercambien información entre ellos. El modelo ha sido integrado en los componentes que se han de evaluar para obtener nuevas métricas sobre esta característica. Se ha desarrollado un dashboard que permite la interacción sin limitaciones de los usuarios con los componentes, facilitándoles un sistema para conectar componentes, utilizando para ello el sistema previamente descrito. Como conclusión del trabajo, se puede observar la necesidad de integrar los componentes web en un entorno real para poder determinar su calidad. Debido a que la calidad está determinada por los usuarios que consumen los componentes, se ha de contar con su opinión en la cuantificación de la misma.---ABSTRACT---Recently, the web has evolved to the collaboration between professional developers and end users with limited knowledge to create web content. Although both solutions are correct and functional, the differences in the quality between them can be appreciable. This feature is shown clearly when the web components are analyzed. The work is composed of the development of a virtual environment which is able to pick the quality measures of the components, based on the interaction between these components and the user. The measures are the starting point to decide the quality, and improve them with the rated measures. The measures selection is done through a study of the main features of a component. This selection can be analyzed. In order to create the website, a prototype has been specified to provide a system in which the components can be trade information between them. The interconnection model has been integrated in the components to evaluate. A dashboard has been developed to allow users interacting with the components without rules, making them possible connecting components through the model. The main conclusion of the work is the necessity of integrating web components in a real environment to decide their quality. Due to the fact that the quality is measured in terms of the rate of the users, it is a must to give them the main roles in the establishment of that quality.

Coordinate regulation of gonadotropin-releasing hormone neuronal firing patterns by cytosolic calcium and store depletion

Elevation of cytosolic free Ca2+ concentration ([Ca2+]i) in excitable cells often acts as a negative feedback signal on firing of action potentials and the associated voltage-gated Ca2+ influx. Increased [Ca2+]i stimulates Ca2+-sensitive K+ channels (IK-Ca), and this, in turn, hyperpolarizes the cell and inhibits Ca2+ influx. However, in some cells expressing IK-Ca the elevation in [Ca2+]i by depletion of intracellular stores facilitates voltage-gated Ca2+ influx. This phenomenon was studied in hypothalamic GT1 neuronal cells during store depletion caused by activation of gonadotropin-releasing hormone (GnRH) receptors and inhibition of endoplasmic reticulum (Ca2+)ATPase with thapsigargin. GnRH induced a rapid spike increase in [Ca2+]i accompanied by transient hyperpolarization, followed by a sustained [Ca2+]i plateau during which the depolarized cells fired with higher frequency. The transient hyperpolarization was caused by the initial spike in [Ca2+]i and was mediated by apamin-sensitive IK-Ca channels, which also were operative during the subsequent depolarization phase. Agonist-induced depolarization and increased firing were independent of [Ca2+]i and were not mediated by inhibition of K+ current, but by facilitation of a voltage-insensitive, Ca2+-conducting inward current. Store depletion by thapsigargin also activated this inward depolarizing current and increased the firing frequency. Thus, the pattern of firing in GT1 neurons is regulated coordinately by apamin-sensitive SK current and store depletion-activated Ca2+ current. This dual control of pacemaker activity facilitates voltage-gated Ca2+ influx at elevated [Ca2+]i levels, but also protects cells from Ca2+ overload. This process may also provide a general mechanism for the integration of voltage-gated Ca2+ influx into receptor-controlled Ca2+ mobilization.

Material matters for learning in virtual networks : A case study of a professional learning programme hosted in a Google+ online community

Date of Acceptance: 13/07/2015

Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry

Homologues of Drosophilia transient receptor potential (TRP) have been proposed to be unitary subunits of plasma membrane ion channels that are activated as a consequence of active or passive depletion of Ca2+ stores. In agreement with this hypothesis, cells expressing TRPs display novel Ca2+-permeable cation channels that can be activated by the inositol 1,4,5-trisphosphate receptor (IP3R) protein. Expression of TRPs alters cells in many ways, including up-regulation of IP3Rs not coded for by TRP genes, and proof that TRP forms channels of these and other cells is still missing. Here, we document physical interaction of TRP and IP3R by coimmunoprecipitation and glutathione S-transferase-pulldown experiments and identify two regions of IP3R, F2q and F2g, that interact with one region of TRP, C7. These interacting regions were expressed in cells with an unmodified complement of TRPs and IP3Rs to study their effect on agonist- as well as store depletion-induced Ca2+ entry and to test for a role of their respective binding partners in Ca2+ entry. C7 and an F2q-containing fragment of IP3R decreased both forms of Ca2+ entry. In contrast, F2g enhanced the two forms of Ca2+ entry. We conclude that store depletion-activated Ca2+ entry occurs through channels that have TRPs as one of their normal structural components, and that these channels are directly activated by IP3Rs. IP3Rs, therefore, have the dual role of releasing Ca2+ from stores and activating Ca2+ influx in response to either increasing IP3 or decreasing luminal Ca2+.