Flora of Jamaica, containing descriptions of the flowering plants known from the island, by William Fawcett and Alfred Barton Rendle.

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Flora of Jamaica, containing descriptions of the flowering plants known from the island, by William Fawcett and Alfred Barton Rendle.

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Flora of Jamaica, containing descriptions of the flowering plants known from the island, by William Fawcett and Alfred Barton Rendle.

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El lloc teatral i el seu espai escènic: artialització en William Shakespeare (c..1590-1611) : actor, empresari, dramaturg

Pensar en William Shakespeare, apropar-se a una de l'obres què més tinta han fet córrer, se'ns presenta com voler trobar una agulla en un paller. Amb tot, aquest treball de recerca a volgut discernir la dramatúrgia de Shakespeare, des de l'òptica espacial i estètica. El seu marc, a l'Anglaterra renaixentista -ss,XVI-XVII-, és: l'abundosa legislació -important l'Acta promulgada l'any 1572, per la reina Elisabet I-; la tipologia constructiva i formal del Lloc del Teatre, amb la formulació empresarial què se’n deriva; l'altre element, la participació de l'espectador implícit. Conclusivament, com l'artialització shakespeariana s'insereix, podem dir, 'dramatològicament', dins l'historiografia general del teatre.

Paper money and national distress: William Huskisson and the early theories of credit, speculation and crises

This paper examines the explanation of commercial crises offered by William Huskisson in 1810 in the wake of the debate on the Bullion Report. Huskisson argued that the suspension of convertibility made it possible to extend issues of paper currency beyond its proper limits. Such an expansion, being in the interest of all parties concerned, would actually take place and stimulate excessive speculations, which would eventually prove unsustainable and bring generalized ruin and distress. Although some elements of this explanations were not new (having been anticipated by writers sucha as James Currie in 1793, William Roscoe in 1793, William Anderson in 1797 and an anonymous in 1796), Huskisson's explanation is more systematic and better organized, and his emphasis on the endogenous character of the crisis and on the instability of the dynamics of trade and credit makes it an interesting foreshadower of the theories of crises that were advanced half a century later.

Long-term follow-up of follicular lymphoma (FL) patients receiving single agent rituximab at two different schedules in trial SAKK 35/98

Background: In FL, Rituximab as a single agent delivered in the standard schedule (4 times weekly) may induce a response rate of 50−70% with an event-free survival (EFS) of 1−3 years according to patients' characteristics. Prolonged Rituximab exposure seems to improve EFS at least in responding patients and to increase the rate of longterm responders. Here we report long-term results of a clinical trial comparing single agent Rituximab delivered in the standard schedule versus prolonged exposure, with focus on the proportion of long-term responders and their characteristics. Material and Methods: Between 1998 and 2002, chemotherapy na¨ıve (n = 64) or pre-treated (n = 138) FL patients received Rituximab in the standard schedule. Those responding or with stable disease were randomized to no further treatment (observation, n = 78) or 4 additional doses of Rituximab given at 2-month intervals (prolonged exposure, n = 73). EFS was calculated from the first dose of standard schedule until progression, relapse, second tumor or death. Results: At a median follow up of 9.4 years and with all living patients having been followed for at least 5 years, the median EFS is 13 months for the observation and 24 months for the prolonged exposure arm (p = 0.0007). In the observation arm 13% had no event at 5-years and only 4% at 8 years, while in the prolonged exposure arm it was 27% at 5 years and remained 21% at 8 years. The only significant prognostic factor for EFS in a multivariate Cox regression was the prolonged Rituximab schedule (hazard ratio 0.58, CI 0.39−0.86, p = 0.007), whereas being chemotherapy na¨ıve, presenting with stage