891 resultados para Cano, Alonso, 1601-1667.


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Background:Malignancies arising in the large bowel cause the second largest number of deaths from cancer in the Western World. Despite progresses made during the last decades, colorectal cancer remains one of the most frequent and deadly neoplasias in the western countries. Methods: A genomic study of human colorectal cancer has been carried out on a total of 31 tumoral samples, corresponding to different stages of the disease, and 33 non-tumoral samples. The study was carried out by hybridisation of the tumour samples against a reference pool of non-tumoral samples using Agilent Human 1A 60-mer oligo microarrays. The results obtained were validated by qRT-PCR. In the subsequent bioinformatics analysis, gene networks by means of Bayesian classifiers, variable selection and bootstrap resampling were built. The consensus among all the induced models produced a hierarchy of dependences and, thus, of variables. Results: After an exhaustive process of pre-processing to ensure data quality--lost values imputation, probes quality, data smoothing and intraclass variability filtering--the final dataset comprised a total of 8, 104 probes. Next, a supervised classification approach and data analysis was carried out to obtain the most relevant genes. Two of them are directly involved in cancer progression and in particular in colorectal cancer. Finally, a supervised classifier was induced to classify new unseen samples. Conclusions: We have developed a tentative model for the diagnosis of colorectal cancer based on a biomarker panel. Our results indicate that the gene profile described herein can discriminate between non-cancerous and cancerous samples with 94.45% accuracy using different supervised classifiers (AUC values in the range of 0.997 and 0.955).

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Este texto es una transcripción aproximada de las principales ideas que el autor desgranó de manera muy informal y distendida en su conferencia durante las III Jornadas Universitarias de Tecnología Educativa, y por tanto carece del rigor metodológico y bibliográfico de cualquier contribución científica. Precisamente,en la conferencia el autor utilizó un estilo impresionista, un tanto provocador, para animar el debate posterior y también unas coloridas transparencias, que son intransferibles al formato de papel de un texto escrito, como tampoco lo son el lenguaje gestual y corporal y la interacción con los participantes

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Scientific missions constitute fundamental cornerstones of space agencies such as ESA and NASA. Modern astronomy could not be understood without the data provided by these missions. Scientists need to design very carefully onboard instruments. Payloads have to survive the crucial launch moment and later perform well in the really harsh space environ-ment. It is very important that the instrument conceptual idea can be engineered to sustain all those loads

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En el libro Glosario General de Tecnología, el profesor D. Enrique Alarcón Álvarez coordina el área destinada a la Construcción y obras públicas, en la que también participa como autor.

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Capítulo enmarcado dentro de la línea de investigación "Luz y Gravedad" que analiza el uso de la luz como material con capacidad para definir el espacio construido.

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Antonio Gobeyos es seudónimo de Benito Martínez Gómez-Gayoso según Aguilar Piñal, V, 3441