No detectable indirect effects of late-onset Cytomegalovirus disease after valganciclovir (VGC) prophylaxis in kidney transplant recipients

Background: Cytomegalovirus (CMV) disease remains an important cause of morbidity after kidney transplantation and has been associated with acute rejection, graft loss and other indirect effects. A 3-month course of VGC prophylaxis reduces the incidence of CMV disease. However, little is known about the indirect effects of lateonset CMV disease after VGC prophylaxis. Objective: To evaluate the impact and indirect consequences of late-onset CMV disease after VGC prophylaxis in kidney transplant recipients. Methods: Retrospective analysis of 61 consecutive adult kidney transplant recipient with positive CMV serology (donor or recipient) who received VGC prophylaxis for 3 months and completed a follow-up of at least 2 years post-transplantation. Patients who developed CMV disease within 1 year after transplantation were compared to CMV disease-free patients for renal function (plasma creatinine values) at 1, 6, 12 and 24 months and for the incidence of graft loss, acute rejection, diabetes, cancer and opportunistic infections. Results: 8/61 (13%) patients developed CMV disease at a median of 131 days after transplantation (range: 98-220). The CMV incidence in D+/R- high risk patients was 6/18 (33%), while it was 2/43 (5%) in intermediate-risk patients (p < 0.01). All 8 patients were treated by oral valganciclovir (median 39 days; range: 19-119) with a complete resolution of CMV disease. As shown in the figure, there was no difference in creatinine values between the two groups at any time during follow-up. There was no graft loss, and the incidence of acute rejection, cancer and opportunistic infections did not differ between the two groups. The incidence of post-transplant diabetes was higher (38% vs 15%) in patients with CMV disease, but this difference was not significant (p = 0.4). Conclusions: An incidence of 13% of late-onset CMV disease was observed despite 3 months VGC prophylaxis. However, no indirect consequences were found. Moreover, therapy of CMV disease by oral VGC was effective and safe. Larger trials are needed to study whether late-onset CMV disease is associated with indirect consequences, as described with early-onset CMV.

Etude des jeunes consommateurs de drogues dures à Bienne et Berne

[Table des matières] 1. Introduction. 2. Résultats. 2.1. Taux de participation. 2.2. Nationalité et migration. 2.3. Antécédents et rapports familiaux. 2.4. Vie sociale et relations avec les pairs. 2.5. Parcours scolaire, vie active et formation professionnelle. 2.6. Santé physique. 2.7. Santé psychique. 2.8. Consommation de drogues. 2.9. Traitement de substitution. 2.10. Partage de seringues et overdoses. 2.11. Relations sexuelles et partenaires. 2.12. Comportement délinquant/criminel. 2.13. Besoins. 3. Conclusions. 4. Recommandations. 5. Annexes. 5.1. Questionnaire quantitatif. 5.2. Grille d'entretien pour les entretiens qualitatifs. 5.3. Grille pour les focus groupes. 5.4. Synthèse des entretiens de six professionnels des structures de soins de Berne.

Efeito de anos e determinação do coeficiente de repetibilidade de características de frutos de goiabeira-serrana

A variância ambiental costuma ser bastante significativa em características de produção e de frutos, a maioria de herança quantitativa. Este estudo teve por objetivo avaliar o efeito de anos e determinar o número de anos necessários para avaliação precisa do peso do fruto, peso de casca, comprimento, diâmetro, relação comprimento/diâmetro, rendimento de polpa e sólidos solúveis totais dos frutos de goiabeira-serrana (Acca sellowiana), em três anos de avaliação. Com exceção de sólidos solúveis totais, o efeito de anos representou grande parte da variância total. A partir do coeficiente de repetibilidade, determinou-se que seriam necessários no mínimo de quatro a seis anos de avaliação para seleção das plantas, com precisão de 80%.

Consommations et interventions en milieu festif

[Content] 1. Introduction. - 1.1. Mandat et questions d'évaluation. - 1.2. Méthode. - 2. Appréciation de la consommation en milieu festif dans le canton de Vaud par les professionnels. - 2.1 Consommation et profil de consommation. - 2.2. Prises de risque et conséquences. - 2.3 Interventions et besoins perçus. - 3. Revue de différentes interventions existantes en Suisse. - 3.1. Historique et objectifs des projets. - 4. Interventions actuelles dans le canton de Vaud. - 4.1. Interventions structurelles. - 5. Avantages et limites des différents types d'intervention répertoriés dans les cantons. - 5.1. Interventions structurelles. - 5.2 Interventions comportementales. - 5.3 Synthèse. - - 6 Conclusions et recommandations pour une intervention en milieu festif dans le canton de Vaud. - 6.1 Bilan du panel de professionnels. - 6.2 Modalités de l'intervention. - 6.3 Recommandations. - 7. Annexes. - 7.1. Fiches projets. - 7.1.1. REPER (secteur Information et projets). - 7.1.2. Fiesta. - 7.1.3. Pôle Prévention jurassien. - 7.1.4. danno.ch. - 7.1.5. Nuit blanche ?. - 7.1.6. saferparty.ch. - 7.1.7. rave it safe.