946 resultados para Arrest
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Mode of access: Internet.
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Mode of access: Internet.
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pt. I. Pioneers of evolution from Thales to Lucretius, B.C. 600-A.D. 50 -- pt. II. The arrest of enquiry A. D. 50-A. D. 1600: 1. From the early Christian period to the time of Augustine, A.D. 50-A.D. 400. 2. From Augustine to Bacon, A. D. 400-A. D. 1600 -- pt. III. The renascence of science, about A. D. 1600 onwards -- pt. IV. Modern evolution: 1. Darwin and Wallace 2. Herbert Spencer. 3. Thomas Henry Huxley.
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Mode of access: Internet.
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Originally published, Oberlain, 1847.
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"April 1982."
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"Illinois Revised Statutes, Chapter 38 Section 7-5."
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Fictitious imprint; printed in Holland.
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Mode of access: Internet.
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Joshua W. Alexander, Chairman.
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Thesis (Master's)--University of Washington, 2016-06
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One common characteristic of breast cancers arising in carriers of the predisposition gene BRCA1 is a loss of expression of the CDK inhibitor p27(Kip1) (p27), suggesting that p27 interacts epistatically with BRCA1. To investigate this relationship, we examined expression of p27 in mice expressing a dominant negative allele of Brca1 (MMTV-trBr) in the mammary gland. While these mice rarely develop tumors, they showed a 50% increase in p27 protein and a delay in mammary gland development associated with reduced proliferation. In contrast, on a p27 heterozygote background, MMTV-trBrca1 mice showed an increase in S phase cells, and normal mammary development. p27 was the only protein in the cyclin cyclin-dependent kinase network to show altered expression, suggesting that it may be a central mediator of cell cycle arrest in response to loss of function of BRCA1. Furthermore, in human mammary epithelial MCF7 cells expressing BRCA1-specific RNAi and in the BRCA1-deficient human tumor cell line HCC1937, p27 is elevated at the mRNA level compared to cells expressing wild-type BRCA1. We hypothesize that disruption of BRCA1 induces an increase in p27 that inhibits proliferation. Accordingly, reduction in p27 expression leads to enhancement of cellular proliferation in the absence of BRCA1.