Transplant glomerulopathy: clinico-pathologic features

Transplant glomerulopathy is a sign of chronic kidney allograft damage. It has a distinct morphology and is associated with poor allograft survival. We aimed to assess the prevalence and clinic-pathologic features of transplant glomerulopathy, as well as determine the functional and histological implications of its severity. We performed a single-centre retrospective observational study during an eight-year period. Kidney allograft biopsies were diagnosed and scored according to the Banff classification, coupled with immunofluorescence studies. The epidemiology, clinical presentation, outcomes (patient and graft survival) and anti-HLA alloantibodies were evaluated. Transplant glomerulopathy was diagnosed in 60 kidney transplant biopsies performed for clinical reasons in 49 patients with ABO compatible renal transplant and a negative T-cell complement dependent cytotoxicity crossmatch at transplantation. The estimated prevalence of transplant glomerulopathy was 7.4% and its cumulative prevalence increased over time. C4d staining in peritubular capillaries (27.6%) was lower than the frequency of anti-HLA antibodies (72.5%), the majority against both classes I and II. Transplant glomerulopathy was associated with both acute (mainly glomerulitis and peritubular capillaritis) and chronic histologic abnormalities. At diagnosis, 30% had mild, 23.3% moderate and 46.7% severe transplant glomerulopathy. The severity of transplant glomerulopathy was associated with the severity of interstitial fibrosis. Other histological features, as well as clinical manifestations and graft survival, were unrelated to transplant glomerulopathy severity.

Letter, Society Hill, SC, to George Washington Spencer, Chesterfield, SC, 1892 February 22

This letter is from the King Iron Bridge Manufacturing Company to G. W. Spencer.

Coastal storm snow event : November 20-22, 2006 open-file report

This report describes climatologically, the snow storm that occurred from November 20-22, 2006.

Where the consumer is not a myth : letters from England describing economic and industrial conditions by Zach McGhee, Washington correspondent : speech of Hon. Wyatt Aiken in the House of Representatives, Tuesday, March 22, 1910

This document contains a speech of David Wyatt Aiken, representative of South Carolina, to the House of Representatives on Tuesday, March 22, 1910. Much of the speech is a letter from Zach McGhee, Washington correspondent of The State newspaper on industrial conditions in England and Europe.

Marriage of Figaro, January 22, 1940

Concert program for Marriage of Figaro, January 22, 1940

Senior Recital, May 22, 1971

Concert program for Senior Recital, May 22, 1971