Friday Facts, July 16, 2010, Vol. 63

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.

U.S. 63 dedication, Chester, Iowa, November 24, 1982

Program from the dedication of U.S. 63 near Chester, Iowa. Includes project description and contractor information.

[Archives de la parole]. , [Chanson à la jolie bergère] ; [Ah j'y viens, je m'y promène] : [chanson du berger] / [Gabriel Bonnin, 63 ans, cultivateur]

[Traditions. France. Berry]

[Archives de la parole]. , [Conversation sur le chanvre] / [Ferdinand Brunot], collecteur ; [Marie Viaud, 52 ans, cultivatrice], voix ; [Gabriel Bonnin, 63 ans, cultivateur], voix. [Conversation sur le chanvre] / [Ferdinand Brunot], collecteur ; [Marie Viaud, 52 ans, cultivatrice] ; [Solange Rémi, Solange Rémi, 79 ans, cultivatrice], voix

[Traditions. France. Berry]

[Archives de la parole]. , [Chanson du laboureur] : [chanson] ; [Briolée aux boeufs] : [chant] / [Ferdinand Brunot], collecteur ; [Jean Berger, 26 ans, garçon de ferme], chant. [Chanson à la jolie bergère] / [Ferdinand Brunot], collecteur ; [Gabriel Bonnin, 63 ans, cultivateur], chant

[Traditions. France. Berry]

[Archives de la parole]. , [Dialogue sur la lessive] / [Ferdinand Brunot], collecteur ; [Solange Rémi, 79 ans, cultivatrice], voix ; [Marie Viaud, 52 ans, cultivatrice], voix. [Conversation sur la vigne] / [Ferdinand Brunot], collecteur ; [Solange Rémi, 79 ans, cultivatrice], voix ; [Gabriel Bonnin, 63 ans, cultivateur], voix

[Traditions. France. Berry]

[Archives de la parole]. , [Chanson de Jean Flambart] / [Ferdinand Brunot], collecteur ; [Gabriel Bonnin, 63 ans, cultivateur], chant

[Traditions. France. Berry]

The diagnostic challenge of progressive pseudorheumatoid dysplasia (PPRD): A review of clinical features, radiographic features, and WISP3 mutations in 63 affected individuals.

Progressive pseudorheumatoid dysplasia (PPRD) is a genetic, non-inflammatory arthropathy caused by recessive loss of function mutations in WISP3 (Wnt1-inducible signaling pathway protein 3; MIM 603400), encoding for a signaling protein. The disease is clinically silent at birth and in infancy. It manifests between the age of 3 and 6 years with joint pain and progressive joint stiffness. Affected children are referred to pediatric rheumatologists and orthopedic surgeons; however, signs of inflammation are absent and anti-inflammatory treatment is of little help. Bony enlargement at the interphalangeal joints progresses leading to camptodactyly. Spine involvement develops in late childhood and adolescence leading to short trunk with thoracolumbar kyphosis. Adult height is usually below the 3rd percentile. Radiographic signs are relatively mild. Platyspondyly develops in late childhood and can be the first clue to the diagnosis. Enlargement of the phalangeal metaphyses develops subtly and is usually recognizable by 10 years. The femoral heads are large and the acetabulum forms a distinct "lip" overriding the femoral head. There is a progressive narrowing of all articular spaces as articular cartilage is lost. Medical management of PPRD remains symptomatic and relies on pain medication. Hip joint replacement surgery in early adulthood is effective in reducing pain and maintaining mobility and can be recommended. Subsequent knee joint replacement is a further option. Mutation analysis of WISP3 allowed the confirmation of the diagnosis in 63 out of 64 typical cases in our series. Intronic mutations in WISP3 leading to splicing aberrations can be detected only in cDNA from fibroblasts and therefore a skin biopsy is indicated when genomic analysis fails to reveal mutations in individuals with otherwise typical signs and symptoms. In spite of the first symptoms appearing in early childhood, the diagnosis of PPRD is most often made only in the second decade and affected children often receive unnecessary anti-inflammatory and immunosuppressive treatments. Increasing awareness of PPRD appears to be essential to allow for a timely diagnosis. © 2012 Wiley Periodicals, Inc.

Punção aspirativa por agulha fina guiada por ultra-sonografia de nódulos tireoidianos: estudo de 63 casos

Neste trabalho foi revisada a técnica empregada na execução da punção aspirativa por agulha fina guiada por ultra-sonografia, e são descritos os seus benefícios no diagnóstico de nódulos tireoidianos. Foram realizadas punções aspirativas por agulha fina em 63 pacientes do Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro, encaminhados ao Serviço de Radiodiagnóstico, no período de agosto de 2001 a junho de 2002. Dos 63 pacientes estudados, 58 (92%) eram do sexo feminino e cinco (8%) eram do sexo masculino, com uma relação mulher/homem de cerca de 11:1. Trinta e um pacientes (49%) se situaram na quinta e sexta décadas de vida. Oitenta e nove por cento dos pacientes apresentaram-se com nódulos múltiplos ao exame ecográfico; apenas 11% dos pacientes tinham nódulo único. Em relação aos laudos citológicos dos nódulos puncionados, 47% foram benignos, 31%, suspeitos, 17%, inadequados e apenas 5%, malignos. Todos os nódulos malignos (três pacientes) tiveram o diagnóstico citológico de carcinoma papilífero. Dos nódulos benignos, 93% foram diagnosticados como hiperplasia nodular e apenas 7% tiveram diagnóstico de tireoidite. Dos laudos considerados inadequados, 70% foram considerados hemorrágicos, sendo 30% considerados hipocelulares. Os dados encontrados no nosso trabalho estiveram de acordo com os encontrados na literatura médica.