998 resultados para 13-123
Resumo:
Référence bibliographique : Rol, 57222
Resumo:
Référence bibliographique : Rol, 57211
Resumo:
Weekly newsletter for the State of Iowa Alcoholic Beverages Division
Resumo:
Newsletter produced by the Iowa Information Technology Department
Resumo:
Référence bibliographique : Rol, 54836
Resumo:
Référence bibliographique : Rol, 54837
Resumo:
Référence bibliographique : Rol, 54838
Resumo:
Référence bibliographique : Rol, 54839
Resumo:
Référence bibliographique : Rol, 54842
Resumo:
Référence bibliographique : Rol, 54841
Resumo:
Référence bibliographique : Rol, 54840
Resumo:
Référence bibliographique : Rol, 54843
Resumo:
Canids are natural reservoirs of Leishmania infantum and have been promoted as experimental hosts to decipher the pathogenesis of human visceral leishmaniasis (VL). In this study, the presence of IgG antibodies as well as the presence of mononuclear leukocytes reactive to different cysteine proteinases (CPs) were examined in 13 L. infantum-infected dogs (six with symptoms, seven asymptomatic). Cysteine proteinases which belong to papain-like enzymes known as clan CA are the most studied CPs of parasite protozoa. These molecules are expressed by the intracellular stages of the parasite and could be immunogenic. We studied Type II CP (CPA) and Type I CP (CPB) with its long C-terminal extension (CTE) which could be highly immunogenic. We showed that the level of antibodies reactive to rCPA is low in both symptomatic and asymptomatic dogs. In contrast, when CPB and CTE were used as antigens, the level of total IgG (with IgG2 superior to IgG1) reached higher values in asymptomatic dogs than in dogs with VL. While the peripheral blood mononuclear cell (PBMC) reactivity was significant when cultured in the presence of freezed/thawed (F/T) lysate, it remained low in presence of CP although always higher for PBMC recovered from asymptomatic dogs. We showed the importance of CPB and CTE in particular as a target of immune response and their potential use for serodiagnosis in asymptomatic dogs.
Resumo:
This is a quarterly newsletter for communities and economic developers in Iowa and surrounding states.