Some Comments on Q-Irresolute and Quasi-Irresolute Functions

The aim of this paper is to continue the study of θ-irresolute and quasi-irresolute functions as well as to give an example of a function which is θ-irresolute but neither quasi-irresolute nor an R-map and thus give an answer to a question posed by Ganster, Noiri and Reilly. We prove that RS-compactness is preserved under open, quasi-irresolute surjections.

On Multidimensional Analogue of Marchaud Formula for Fractional Riesz-Type Derivatives in Domains in R^n

2000 Mathematics Subject Classification: 26A33, 42B20

Applications of the Owa-Srivastava Operator to the Class of K-Uniformly Convex Functions

2000 Mathematics Subject Classification: Primary 30C45, 26A33; Secondary 33C15

On Generalized Weyl Fractional q-Integral Operator Involving Generalized Basic Hypergeometric Functions

Mathematics Subject Classification: 33D60, 33D90, 26A33

A Note on Univalent Functions with Finitely many Coefficients

MSC 2010: 30C45

Multipliers on Spaces of Functions on a Locally Compact Abelian Group with Values in a Hilbert Space

2000 Mathematics Subject Classification: Primary 43A22, 43A25.

Kadec Norms on Spaces of Continuous Functions

2000 Mathematics Subject Classification: Primary: 46B03, 46B26. Secondary: 46E15, 54C35.

On the approximation by convolution operators in homogeneous Banach spaces on R^d

AMS Subject Classification 2010: 41A25, 41A35, 41A40, 41A63, 41A65, 42A38, 42A85, 42B10, 42B20

On Generalized Models and Singular Products of Distributions in Colombeau Algebra G(R)

MSC 2010: 46F30, 46F10

The Deformed Trigonometric Functions of two Variables

MSC 2010: 33B10, 33E20

On the Approximation by Convolution Operators in Homogeneous Banach Spaces of Periodic Functions

AMS Subject Classification 2010: 41A25, 41A27, 41A35, 41A36, 41A40, 42Al6, 42A85.

New Coefficient Conditions for Functions Starlike with Respect to Symmetric Points

2000 Mathematics Subject Classification: Primary 30C45, secondary 30C80.

To what extent and in what manner do Chinese and Indian contract research organisation learn and upgrade with the unbundling the global pharmaceutical R&D value chain?

The paper applies the GVC framework to analyse the organisational and geographical reconfiguration of the global R&D function of leading US and European pharmaceutical MNCs. Though pharmaceutical MNCs have been outsourcing clinical trial activities since the mid-1990s, the outsourcing of discovery research tasks is a phenomenon of the 2000s (Ramirez 2013). Moreover, in the context of a crisis of R&D productivity and increasing pressure from shareholders, a number of US and European pharmaceutical MNCs are breaking up their R&D function in an attempt to increase flexibility and reduce risk as well as costs and are thereby restructuring the global architecture of their R&D function. This break-up, or unbundling (Sako 2006), of the R&D function is particularly interesting given the prevalence of market failure in innovation (Howells et al 2008), the non-modular nature of the R&D process in this industry (Pisano 2006) and the strategic important of this activity to the core competence and long-term competitive advantage of firms in this sector. The focus of this paper is on the outsourcing of R&D activities to Chinese and Indian independently-owned contract research organisations (CROs) and the way these firms are becoming integrated as service providers into the global R&D function (or R&D value chain) of pharmaceutical MNCs. Above all the paper is concerned with the development of capabilities of CROs from these two countries and the dynamics of upgrading in GVCs in knowledge-intensive functions. The paper therefore discusses the role of both knowledge flows within global pharmaceutical R&D value chains as well as national innovation systems on the development of capabilities of Chinese and Indian CROs. Our analysis is based on data from semi-structured interviews collected from senior R&D managers from a sample of ten US and European pharmaceutical MNCs and owners and senior R&D managers from five Chinese and five Indian CROs who are providing research services to MNCs in this industry. We discuss the emergence of R&D outsourcing in this industry and the nature and mechanisms of knowledge flows within R&D value chains. The embeddedness of CROS in the national innovation systems of their home countries is also discussed.

Desenvolvimento biotecnológico de uma emulsão de uso tópico a base de óleo de rã-touro Rana catesbeiana Shaw

The skin is one of the largest organs of the human body and accounts for about 16% of body weight. The body protection against the external environment microorganisms is one of its most important functions, however is necessary that the skin remain intact for this function be exercised, so that when there is an injury on the skin, the process of restructuring needs to be starts, however this restructuration may also be compromised due to some diseases, justifying even more the need for the development of topical products that promote or accelerate the skin healing. Thus the aim of this study was to extract bullfrog oil and to develop a suitable topical emulsion. Two different oil samples were extracted by hot or organic solvent process. Titration techniques and gas chromatography- mass spectrometry were used to characterize the bullfrog oil. The required hydrophile-lipophile balance (HLBr) of bullfrog oil was determined and a pseudo-ternary phase diagram was constructed. The stability of the topical emulsion was evaluated. Then, cellular viability was determined by MTT assay using normal fibroblasts (3T3) and melanoma (B16F10) cells lines. The hot extraction yield was 60.6%. The major polyunsaturated compounds found were Eicosapentaenoic acid (17.6%) and Arachidonic acid (8.4%). HLBr study demonstrated the presence of stable systems with HLB ranging from 12.1 to 13.5 and the pseudo-ternary phase diagram showed mainly emulsion systems (62%). Topical emulsion showed 390 nm, polydispersity 0.05, zeta potential -25 mV and remained stable for ninety days. The bullfrog oil and topical emulsion did not showed citotoxicity in normal fibroblasts cells. However, these systems showed significantly inhibition of melanoma cells growth. In conclusion, the bullfrog oil presented desirable chemical characteristics required to be used for the development of a pharmaceutical and cosmetic products.