Calendario de conferencias de la CEPAL propuesto para el período 1998-2000 = Proposed ECLAC calendar of conferences for the period 1998-2000 = Calendrier des conférences de la CEPALC proposé pour la période 1998-2000

Twenty-seventh session. Oranjestad, Aruba, 11-16 May 1998

Proposed ECLAC calendar of conferences for the period 2000-2002

Includes bibliography

Calendario de reuniones intergubernamentales de la CEPAL propuesto para el período 1982-1984: nota de la Secretaría = Calendar of intergovernmental meetings of CEPAL proposed for the period 1982-1984: note by the Secretariat

Incluye las reuniones estatutorias de la CEPAL, reuniones de organos subsidiarios de la Comision y reuniones regionales latinoamericanas preparatorias para conferencias mundiales de las Naciones Unidas.

Proposed guidelines for the biennial programme of regional and international cooperation activities, 2007-2009

Includes bibliography

Report of the Secretariat on the proposed gender observatory for Latin America and the Caribbean

Includes bibliography

Proposed regional plan for the implementation of the Luxembourg recommendations

Includes bibliography

A new proposed rodent model of chemically induced prostate carcinogenesis: Distinct time-course prostate cancer progression in the dorsolateral and ventral lobes

Background. Characterization of novel rodent models for prostate cancer studies requires evaluation of either spontaneous and carcinogen-induced tumors as well as tumor incidence in different prostatic lobes. We propose a new short-term rodent model of chemically induced prostate carcinogenesis in which prostate cancer progression occurs differentially in the dorsolateral and ventral lobes. Methods. Adult gerbils were treated with MNU alone or associated with testosterone for 3 or 6 months of treatment. Tumor incidence, latency, localization, and immunohistochemistry (AR, PCNA, smooth muscle α-actin, p63, MGMT, and E-cadherin) were studied in both lobes. Results. Comparisons between both lobes revealed that lesions developed first in the DL while the VL presented longer tumor latency. However, after 6 months, there was a dramatic increase in tumor multiplicity in the VL, mainly in MNU-treated groups. Lesions clearly progressed from a premalignant to a malignant phenotype over time and tumor latency was decreased by MNU + testosterone administration. Three-dimensional reconstruction of the prostatic complex showed that the DL developed tumors exclusively in the periurethral area and showed intense AR, PCNA, and MGMT immunostaining. Moreover, VL lesions emerged throughout the entire lobe. MNU-induced lesions presented markers indicative of an aggressive phenotype: lack of basal cells, rupture of the smooth muscle cell layer, loss of E-cadherin, and high MGMT staining. Conclusions. There are distinct pathways involved in tumor progression in gerbil prostate lobes. This animal provides a good model for prostate cancer since it allows the investigation of advanced steps of carcinogenesis with shorter latency periods in both lobes. Copyright © 2013 Wiley Periodicals, Inc.

Propuesta de programa de acción para las mujeres de América Latina y el Caribe = Proposed programme of action for the women of Latin America and the Caribbean

Incluye Bibliografía

Draft summary of proposed work programme output for the 1990-1991 biennium

Includes bibliography

Proposed work programme of the Economic Commission for Latin America and the Caribbean Subregional Headquarters for the Caribbean for the 1992-1993 biennium = Projet de programme de travail du siege sous-régional pour les Caraïbes de la CEPAL: exercice biennal 1992-1993

Contiene la propuesta del programa de trabajo de la CEPAL, Puerto España, para el bienio 1992-1993, con las principales áreas de trabajo y actividades dentro del subprograma integración económica y cooperación entre los países del Caribe.

Proposed changes to the 1990-91 work programme

Contiene los cambios propuestos al programa de trabajo 1990-91 por elementos de programa.