324 resultados para fibrose kystique


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Silicosis, a common type of pneumoconiosis, is an occupational lung disease caused by inhalation of silica dust often with mining activity and thus reaches the miners. The fine and ultrafine silica particles deposited in the alveolar epithelium may lead to the development of progressive massive fibrosis. An increased reactive oxygen species (ROS) production has been proposed to explain the mechanism for induction of pulmonary fibrosis in silicosis. In this situation, alveolar macrophages are activated to phagocytes silica particles deposited in the alveoli. The activated macrophages secrete large amounts of ROS that in turn induce synthesis of fibrotic factors. In addition, the activity of antioxidant enzymes is impaired, which results in increased lipid peroxidation, as well as generating a local inflammatory process. Diffuse pulmonary fibrosis progresses with interstitial collagen deposition. Interstitial collagen overlies small pulmonary arteries and arterioles and thus it is associated with pulmonary hypertension in pulmonary fibrotic diseases. In addition, cytokines and silica particles passing through the respiratory membrane can reach the bloodstream. In this context, the increase in the generation of ROS in the circulation may lead to a reduction in the bioavailability of nitric oxide, an important endothelium-derived relaxing factor. A deficiency in the nitric oxide bioavailability can result in vascular endothelial dysfunction. Moreover, pro-inflammatory cytokines could contribute to the impairment of endothelial function. In the airways, pro-inflammatory cytokines can reduce the smooth muscle responsiveness to β- adrenergic agonists as isoproterenol. Thus, the aim of this study was to evaluate the effect of silica dust instillation in the function of the pulmonary artery, aorta and trachea of rats with acute silicosis. For this purpose, male Wistar rats were anesthetized... (Complete abstract click electronic access below)

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Infection with hepatitis C virus (HCV) is a worldwide problem of public health and who estimates 2.5% to 4.9% of infection by this virus among the population. This means that there are 3.9 to 7.6 million people at risk of developing cirrhosis or liver cancer. In Brazil, 20% to 58% of patients with chronic liver disease have antibodies to HCV (anti-HCV). To characterize the profile of patients undergoing treatment for hepatitis C in the Ambulatory General HC-FMB/UNESP, identify aspects of the disease and the phases of nursing process addressed during consultation. Transverse and descriptive study involving 38 patients undergoing treatment for Hepatitis C in Ambulatory General Area (Viral Hepatitis) in the period from July to September 2010. The population consisted of 38 patients, most of the males with completed higher education level, Catholic, married and aged predominantly between 41 and 60 years. Among the drugs used, we find the use of antihypertensive, antidepressant / anxiolytic and antidiabetic / hypoglycemic. With respect to specific medications used to treat hepatitis C, we found the use mainly of alfapeguinterferona 2b + ribavirin. The drugs used were complementary erythropoietin and filgastrim. There was a predominance of fibrosis 2 (F2) and genotype 1 (G1). Regarding the means of contamination, it was stressed blood transfusion and injection drug use. The most frequent drug reactions were decreased appetite, weight loss and discouragement. : The Nursing Process is considered a valuable tool in caring for patients with hepatitis C, because it works as identifying aspects of lifestyle, needs and potential of these patients and allows the deployment of humanized care strategies aimed at reduction of health hazards and improving the quality of life of these patients

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Pancreatitis is a predominantly disease of the exocrine pancreas, which occurs commonly in dogs. Acute pandreatitis is reversible, with the removal of the primary cause, whereas chronic pancreatitits is irreversible, with histopathological changes, such as atrophy and fibosis that occurs from persistent inflammation. In dogs, clinicl signs ranging among abdominal pain and anorexia until potential insufficiency of various organs and Disseminated Intravascular Coagulation. In general, dogs with acute illness presents vomiting, anorexia, abdominal pain and several degrees of dehydration, collapse and shock. The caim of this monograph is evaluate ultrassound changes in dogs with panceatitis. Ultrassound is a valuable technique to evaluate exocrine pancreas, with association with another diagnostic modalities will be able to increase the preciosion of the diagnosis

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O Programa Nacional de Triagem Neonatal (PNTN), popularmente conhecido como “Teste do Pezinho”, é responsável pelo rastreamento das seguintes doenças nos recém-nascidos brasileiros: Fenilcetonúria, Hipotiroidismo Congênito, Doenças Falciformes e demais Hemoglobinopatias, e Fibrose Cística. Seu objetivo é o diagnóstico precoce dessas doenças congênitas em fase assintomática, buscando prevenir o aparecimento de sequelas neurológicas e outras complicações por meio do acompanhamento e tratamento adequados. O PNTN, além de realizar o diagnóstico pré-clínico de doenças que constituem problemas de saúde pública, gera informações que podem ser usadas em estudos epidemiológicos fundamentais para o planejamento de programas de saúde. Para que esse sistema seja completo, no entanto, é necessário haver o treinamento dos profissionais da saúde envolvidos no assunto, bem como a implantação de atividades educativas para estes e para o público em geral. Neste contexto, este estudo retrospectivo propõe investigar a relação de resultados alterados das doenças detectadas pelo PNTN entre os meses de abril e dezembro de 2009 e janeiro e dezembro de 2010 no município de Araraquara, verificar se as primeiras coletas de sangue estão sendo feitas segundo as recomendações do Ministério da Saúde e capacitar agentes comunitários da saúde nesse assunto. Foram analisados 4.116 resultados. Não houve diferença significativa entre as prevalências obtidas em 2009 e 2010, ou seja, as freqüências das patologias estudadas se mantiveram praticamente constantes ao longo dos dois períodos

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Pós-graduação em Medicina Veterinária - FCAV

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)