926 resultados para Wilson, George
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Référence bibliographique : Rol, 57640
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Référence bibliographique : Rol, 57056
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Référence bibliographique : Rol, 57554
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Référence bibliographique : Rol, 57738
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Référence bibliographique : Rol, 57547
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Référence bibliographique : Rol, 57209 bis
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Référence bibliographique : Rol, 58114
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Référence bibliographique : Rol, 57551
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Référence bibliographique : Rol, 57998
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Wilson disease (WD) is an inherited disorder of hepatic copper excretion leading to toxic accumulation of copper in the liver as well as the brain, cornea, and other organs. The defect is due to mutations of the copper-transporting ATPase ATP7B. Clinical manifestations are highly variable and comprise acute liver failure, chronic hepatitis and cirrhosis as well as neurological or psychiatric symptoms. The Kayser-Fleischer corneal ring is pathognomonic but absent in about 50% of patients with hepatic manifestations alone. A high index of suspicion in clinically compatible situations is key, with a combination of laboratory tests allowing the diagnosis of WD. Treatment is based on the use of chelating agents, D-penicillamine or trientine. Liver transplantation should be considered for patients with acute liver failure or advanced cirrhosis.
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[Traditions. Asie. Inde. Présidence de Madras [i.e. Chennai]. Ceded Districts]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. Etat du Tamil Nadu]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. Région de Kanara]
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[Traditions. Asie. Inde. Présidence de Bombay. Pakistan. Province du Sind. Tharparkar]