List of Bid Proposal Holders, May 21, 2013

List of Bid Proposal Holders

List of Bid Proposal Holders, June 18, 2013

List of Bid Proposal Holders

List of Bid Proposal Holders, July 16, 2013

List of Bid Proposal Holders

List of Bid Proposal Holders, August 20, 2013

List of Bid Proposal Holders

List of Bid Proposal Holders, September 17, 2013

List of Bid Proposal Holders

List of Bid Proposal Holders, October 4, 2013

List of Bid Proposal Holders

List of Bid Proposal Holders, November 19, 2013

List of Bid Proposal Holders

Iowa Medicaid Pharmaceutical and Therapeutics Committee and Diabetes Treatment Preferred Drug List, December 16, 2008

This document was produced to help the state and citizens of Iowa with the price list of preferred drug list of medicines that diabetics can use.

List of Bid Proposal Holders, December 17, 2013

List of Bid Proposal Holders

Stored red blood cells: a changing universe waiting for its map(s).

The availability of stored red blood cells (RBCs) for transfusion remains an important aspect of the treatment of polytrauma, acute anemia or major bleedings. RBCs are prepared by blood banks from whole blood donations and stored in the cold in additive solutions for typically six weeks. These far from physiological storage conditions result in the so-called red cell storage lesion that is of importance both to blood bankers and to clinical practitioners. Here we review the current state of knowledge about the red cell storage lesion from a proteomic perspective. In particular, we describe the current models accounting for RBC aging and response to lethal stresses, review the published proteomic studies carried out to uncover the molecular basis of the RBC storage lesion, and conclude by suggesting a few possible proteomic studies that would provide further knowledge of the molecular alterations carried by RBCs stored in the cold for six weeks.

List of Bid Proposal Holders, January 22, 2014

List of Bid Proposal Holders

List of Bid Proposal Holders, March 18, 2014

List of Bid Proposal Holders

List of Bid Proposal Holders, April 15, 2014

List of Bid Proposal Holders

Creating a list of low-value health care activities in Swiss primary care.

Trisomy 21 is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in trisomy 21, and to eliminate the noise of genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for trisomy 21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either upregulated or downregulated. These gene expression dysregulation domains (GEDDs) can be defined by the expression level of their gene content, and are well conserved in induced pluripotent stem cells derived from the twins' fibroblasts. Comparison of the transcriptome of the Ts65Dn mouse model of Down's syndrome and normal littermate mouse fibroblasts also showed GEDDs along the mouse chromosomes that were syntenic in human. The GEDDs correlate with the lamina-associated (LADs) and replication domains of mammalian cells. The overall position of LADs was not altered in trisomic cells; however, the H3K4me3 profile of the trisomic fibroblasts was modified and accurately followed the GEDD pattern. These results indicate that the nuclear compartments of trisomic cells undergo modifications of the chromatin environment influencing the overall transcriptome, and that GEDDs may therefore contribute to some trisomy 21 phenotypes.

List of Bid Proposal Holders, May 20, 2014

List of Bid Proposal Holders