Effect of preventive treatment for tuberculosis in adults infected with HIV: systematic review of randomised placebo controlled trials

Objective: To determine whether preventive treatment for tuberculosis in adults infected with HIV reduces the frequency of tuberculosis and overall mortality.

Crystal structure of cytochrome P450 14α-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

Cytochrome P450 14α-sterol demethylases (CYP51) are essential enzymes in sterol biosynthesis in eukaryotes. CYP51 removes the 14α-methyl group from sterol precursors such as lanosterol, obtusifoliol, dihydrolanosterol, and 24(28)-methylene-24,25-dihydrolanosterol. Inhibitors of CYP51 include triazole antifungal agents fluconazole and itraconazole, drugs used in treatment of topical and systemic mycoses. The 2.1- and 2.2-Å crystal structures reported here for 4-phenylimidazole- and fluconazole-bound CYP51 from Mycobacterium tuberculosis (MTCYP51) are the first structures of an authentic P450 drug target. MTCYP51 exhibits the P450 fold with the exception of two striking differences—a bent I helix and an open conformation of BC loop—that define an active site-access channel running along the heme plane perpendicular to the direction observed for the substrate entry in P450BM3. Although a channel analogous to that in P450BM3 is evident also in MTCYP51, it is not open at the surface. The presence of two different channels, with one being open to the surface, suggests the possibility of conformationally regulated substrate-in/product-out openings in CYP51. Mapping mutations identified in Candida albicans azole-resistant isolates indicates that azole resistance in fungi develops in protein regions involved in orchestrating passage of CYP51 through different conformational stages along the catalytic cycle rather than in residues directly contacting fluconazole. These new structures provide a basis for rational design of new, more efficacious antifungal agents as well as insight into the molecular mechanism of P450 catalysis.

Livestock health encyclopedia; the control of diseases and parasites in cattle, sheep and goats, swine, horses and mules. /

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Tuberculosis and the Koch test /

"New series" vol. II, no. 3.

Economic factors in cattle feeding.

Cover title.

Serological diagnosis of brucella in cattle,

Translated from Revista de Zootehnie si Medicina Veterinara, Rumanian, no. 10, 1967 pp. 36-51.

A study of infectious abortion in cattle,

Reprinted from: Cornell University. New York State Veterinary College. Annual report, 1912/13, p.82-114.

Die Rindertuberkulose und ihre Bekämpfung in ihrer Bedeutung für Veihzüchter und Milchwirte unter besonderer Berücksichtigung des neuen Reichsviehseuchengesetzes.

Mode of access: Internet.

A preliminary report on a pneumonia in cattle due to a new species of Actinomyces (Streptothrix).

Reprinted from: New York State Veterinary College, Annual Report, 1909-1910, p. 167-175.

Bluetongue disease in cattle (Ibaraki virus) : a bibliography /

Cover title.

Ketosis (acetonemia) an annotated bibliography of this disease in cattle and sheep, August 1953.

Mode of access: Internet.

[Tuberculosis eradication : miscellaneous collected papers] /

Title supplied by cataloger.