998 resultados para Toxicidade Teses
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Aquatic ecosystems are suffering many impacts caused by human activities resulting from the activities occurring around them. With technological progress observed in recent years, this environment has received large amounts of chemicals from industries, agriculture and urban area that affect the aquatic biota. Among these sources of contamination, the oil industry has contributed to the pollution of aquatic environments with both effluents as produced water well as oil spills and their derivatives having toxicity to various organisms. With all the environmental issues has increased concern about water quality and has been used ecotoxicological tests with aquatic organisms to ecosystems to assess the toxicity of chemicals present in the water. In this context the microcrustacea Daphnia similis stands out as a freshwater organism very representative of the aquatic fauna of rivers and high sensitivity to environmental impacts. Thus, the present study aimed to evaluate the lethal toxicity of crude oil and produced water on this microcrustacea. The results showed that the microcrustacea presented high sensitivity to contaminants primarily crude oil. There was also the influence of environmental variables pH and temperature on the survival of organisms
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Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq)
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Ethanol production has gained great prominence in the investment new renewable energy sources and Brazil is among the leaders of production. However, this activity generates large amounts of waste being the largest volume of the sugar cane bagasse. For this reason looking up ways to use this material as burning for energy production and composition of forage in the diet of ruminants, however there are difficulties to use this production for this last one. This paper proposes a microbiological treatment with Lentinula edodes and Pleurotus ostreatus in order to enable the bagasse in ruminant feed composition in order to be used more noble than their burning. After treatment with the fungus, tests were performed for quantifying crude protein by the method of Kjeldhal. It was verified that the protein content in the pure bagasse was 1.0% after fermentation the protein content was 4.2% with L.edodes and 4.9% with P. ostreatus. To evaluate the protein quality of the product fermented by L. edodes and P. ostreatus was applied microbiological method for growth of Enterococcus zimogenes verifying that after fermentation the protein quality was 76 and 27.4% with L. edodes and P.ostreatus, respectively, compared with casein. The quantification of amino acids showed significant improvement of protein with altered amino acid profile with treatments of fungos. About of DQO and BOD were also found considerable improvement besides considerable drop in toxicity as measured by acute toxicity test with Daphinia similis
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP)
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Ps-graduao em Agronomia (Gentica e Melhoramento de Plantas) - FCAV
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Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES)
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Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP)
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A inflamao basicamente uma resposta de proteo tissular cuja funo proteger o organismo de micro-organismos e toxinas que promovem a leso celular. A resposta inflamatria gera o aparecimento dos quatro sinais cardinais dor, edema, calor e rubor podendo posteriormente ocorrer a perda de funo do tecido ou rgo. Os anti-inflamatrios no esteroides (AINEs) promovem sua atividade alterando a atividade de prostaglandinas (PGs), por inibio das isoformas de ciclo-oxigenases constitutivas (COX1) e induzidas (COX2). A inibio no seletiva destas enzimas (por AINEs clssicos) gera reaes adversas graves, como as reaes gastrointestinais, em pacientes pr-dispostos e/ou que as utilizam por um perodo prolongado. Os AINEs de segunda gerao (inibidores seletivos de COX2), tambm se mostraram txicos, podendo causar alteraes cardiovasculares. Neste sentido, o planejamento de novos compostos com atividade anti-inflamatria e destitudos de toxicidade ainda um desafio para a qumica farmacutica e medicinal. Dois derivados de ibuprofeno (AINE clssico) foram obtidos anteriormente no Lapdesf por Castro (2008) e Vizioli (2006), demonstrando atividade anti-inflamatria em modelo de inflamao aguda (edema de pata) e crnica (colite ulcerativa), destitudos de gastroulcerao (VIZIOLI, 2009). Diante destes resultados o presente estudo visou preparao dos compostos e o estudo pr-clnico de toxicidade em dose nica (aguda) e em doses repetidas em camundongos, bem como as anlises comportamentais, histopatolgicas dos rgos e ensaios bioqumicos. Os achados comportamentais, bioqumicos e histopatolgicos permitem concluir que no foi observada toxicidade nos modelos estudados, exceto para o grupo de administrao dose nica de 2000 mg/kg via intraperitoneal do composto Lapdesf ibu-tau.
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Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq)
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This paper aims to base the thesis that the varied currents of the post-modern thought, in so far as have recourse to relativism to a greater or lesser degree, contribute to the legitimation of the religious education in public schools and, in a broader aspect, the religion in the public spaces. The methodological resource used to demonstrate the link between post-modern thought and religious education is the analysis at the historical and dialectical materialism perspective of publications produced to increase teachers on this discipline that is, in compliance with the Constitution, optional for students and mandatory for public elementary schools. The subject of this analysis is the learning content and has as prime concern to highlight the discourse of legitimation recurrent in authors when it is explicit in itself and explicit when it does not. The religious education in public schools as object of study allows us to understand the relationship between the post-modern thought, with its hegemony space within the human sciences and contextualized in the neoliberal economic environment, and the learning to learn pedagogies currently hegemonic in the educational landscape. We intend to contribute to the legal debate on laity, the philosophical debate on post-modernism and especially to the debate on the pedagogical theories in the educational fundaments.
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The present article aims to elaborate an objective analytical panel, initially from the 1920- 1930 when Luiz Igncio Romeiro de Anhaia Mello, cathedratic in the urban question, started to quote a series of authors and American plans as references to their reflections, mainly when the point was the verticalization or not at So Paulo City. From a broad bibliographic research with the systematization of the register from the debate between Anhaia Mello, this article intends to point out how the transposition of the urbanistic conceptions to the academic environment happened and, at the same time, the legal normatization of the So Paulo City that resulted in the creation of a draft of the regulations for use and occupation of the soil. The systematizations and analysis were based in a broad reading of the bibliography and documental sources that refer to the proposed theme. The books of the library of FAU-USP, specifically the one from SAGMACS Sociedade de Anlises Grficas e Mecanogrficas Aplicadas aos Complexos Sociais ( Society of Graphical Mechanical-Graphic Analysis Applied to Social Complexes) -, aiming to select papers and the collection of Anhaia Mellos family, so that a reconstruction of the intellectual and professional journey of the Urbanism Professor. The systematization of the collected data and posterior comparison with the bibliographical study was fundamental for the reconstruction of the reflection of Anhaia Mello about the ways of the urban streets and roads at Sao Paulo City should be lead to on the middle of the XX century having as a guideline the debate between Anhaia Mello very common on the 1950s for less important countries when dealing with the organization of the size of industrial metropolis. It was possible to identify the crystallization of one urbanistic proposal for the city: the from Anhaia Mello, that bet on the reversion of the metropolitan cycle by stopping the urban growth by the application of the theoretical conception of the garden city.