La Tronà [ : semanari bilingüe festiu y lliterari.: Año II Número 17 - 19 enero 1913

Microfilm.. Valencia: BV, ca. 1990.

La Tronà [ : semanari bilingüe festiu y lliterari.: Año II Número 18 - 26 enero 1913

Microfilm.. Valencia: BV, ca. 1990.

La Tronà [ : semanari bilingüe festiu y lliterari.: Año II Número 19 - 2 febrero 1913

Microfilm.. Valencia: BV, ca. 1990.

Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism.

Ca(2+)-sensitive kinases are thought to play a role in long-term potentiation (LTP). To test the involvement of Ca2+/calmodulin-dependent kinase II (CaM-K II), truncated, constitutively active form of this kinase was directly injected into CA1 hippocampal pyramidal cells. Inclusion of CaM-K II in the recording pipette resulted in a gradual increase in the size of excitatory postsynaptic currents (EPSCs). No change in evoked responses occurred when the pipette contained heat-inactivated kinase. The effects of CaM-K II mimicked several features of LTP in that it caused a decreased incidence of synaptic failures, an increase in the size of spontaneous EPSCs, and an increase in the amplitude of responses to iontophoretically applied alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate. To determine whether the CaM-K II-induced enhancement and LTP share a common mechanism, occlusion experiments were carried out. The enhancing action of CaM-K II was greatly diminished by prior induction of LTP. In addition, following the increase in synaptic strength by CaM-K II, tetanic stimulation failed to evoke LTP. These findings indicate that CaM-K II alone is sufficient to augment synaptic strength and that this enhancement shares the same underlying mechanism as the enhancement observed with LTP.

Fragment of Father Ab--y's Will, [ca. 1739]

Goodspeed 1.

Father Abbey's Will Cambridge, Dec. 1731. Some time since..., [ca. 1780]

Goodspeed 5, Ford 615.

Father Abbey's Will, Cambridge, Dec. 1731. Some time since..., [ca. 1780]

Goodspeed 6.

Father Abbey's Will. To which is now added, a Letter of Courtship to his virtuous..., [ca. 1800]

Goodspeed 15.

Subjects suggested by John Farrar, ca. 1820s

A handwritten letter to President John Thornton Kirkland with five suggested subjects from John Farrar, the Hollis Professor of Mathematics and Natural Philosophy from 1807 until 1836.

Subjects suggested by Levi Hedge, ca. 1820s

A handwritten letter to President Kirkland with three suggested questions from Levi Hedge, a professor of logic and metaphysics from 1810 to 1827, and the Alford Professor of Natural Religion, Moral Philosophy, and Civil Polity from 1827 to 1832.