Staatstätigkeiten, Parteien und Demokratie. Festschrift für Manfred G. Schmidt

Manfred G. Schmidt ist einer der führenden Politikwissenschaftler Europas. Drei Themen bilden Schwerpunkte in seinem reichhaltigen Werk. Machen Parteien einen Unterschied für das staatliche Handeln? Diese Frage bildet den ersten Schwerpunkt seines Schaffens: In welchen Politikbereichen und unter welchen Bedingungen schlägt sich die Regierungsbeteiligung einer Partei in unterschiedlichen Staatstätigkeiten nieder? Der zweite Schwerpunkt ist die Demokratietheorie. Hier geht es ihm um eine vergleichende Rekonstruktion und Evaluation der verschiedenen Demokratietheorien. Die Arbeiten von Manfred G. Schmidt sind grundsätzlich international vergleichend angelegt. Dennoch galt seine besondere Aufmerksamkeit den politischen Systemen Deutschlands. Dies ist der dritte Schwerpunkt. Die Analyse der politischen Institutionen, des Parteienwettbewerbs und der wohlfahrtsstaatlichen Entwicklung in Deutschland seit dem 19. Jahrhundert waren Gegenstand von vielen Monographien und Aufsätzen. Er betonte insbesondere die Interaktionen von Institutionen und Parteien, die die Bundesrepublik Deutschland auf einem ‚mittleren Weg’ hielten – und schloss damit sowohl an seine international vergleichenden Analysen der Sozial-, Wirtschafts-, Bildungs- und Arbeitsmarktpolitik als auch an seine demokratietheoretischen Überlegungen an. Die Beiträge der Festschrift setzen sich mit dem Werk von Manfred G. Schmidt auseinander. Sie würdigen kritisch seine Verdienste, nehmen seine Befunden und Fragestellungen auf und führen sie in empirischen oder theoretisch-konzeptionellen Analysen weiter.

Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

BACKGROUND Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. OBJECTIVES We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). METHODS First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. RESULTS Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). CONCLUSION Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.

[Cervical cancer screening in Switzerland - current practice and future challenges]

At the beginning of the 20th Century, cervical cancer was the leading cause of death from cancer in women. A marked decline in cervical cancer has been observed since the 1960s, in parallel with the introduction of the Papanicolau (Pap) test as a cytological screening method. Today, Pap smear screening is still the most widely used tool for cervical cancer prevention. Testing for human papillomavirus (HPV) in cervical specimens or a combination of Pap and HPV testing are also now available. In this article we compare current guidelines for cervical cancer screening in Switzerland with those in other European countries. In view of the opportunities offered by HPV testing and, since 2008, HPV vaccination, current guidelines for cervical cancer screening should be updated. Both the choice of screening tests and general organization of cervical cancer screening should be reviewed.

Gedanken zur Gerechtigkeit, Festschrift für Hans Giger zum 80. Geburtstag

Ein hochaktueller Band ist zum 80. Geburtstag des international anerkannten Gelehrten Hans Giger aus der Taufe gehoben worden. Wissenschafter in- und ausländischer Universitäten, des Max-Planck-Institutes in Hamburg, a. Bundespräsident der Schweiz, Bundesrichter, Kassationsgerichtspräsident sowie Vertreter von Wirtschaft, Politik, Verwaltung und Medien veranschaulichen ihre Gedanken zur Gerechtigkeit. Beleuchtet werden etwa Themen wie Lohngerechtigkeit und Wirtschaftsethik, Zuteilung von Spenderorganen, Gerechtigkeit in der Strafjustiz, Chancengleichheit in der Bildung, Sport als Weg zu mehr Gerechtigkeit, Biowissenschaften als ethische Provokation, der Preis der sozialen Gerechtigkeit, Sachgerechtigkeit und Regelungsflut, Ungerechtigkeit durch Mainstream-Denken, Quellen des Rechtsbewusstseins u.a.m. Mit 23 fesselnden Beiträgen und einem Geleitwort von Bundesrätin Doris Leuthard liegt ein Werk vor, das in eindrücklicher Weise das zeitgenössische Gerechtigkeitsempfinden reflektiert.

The need for transparency and good practices in the qPCR literature

Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information. Reporting standards are significantly improved in publications that cite the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines, although such publications are still vastly outnumbered by those that do not.

Mitotic figure counts are significantly overestimated in resection specimens of invasive breast carcinomas

Several authors have demonstrated an increased number of mitotic figures in breast cancer resection specimen when compared with biopsy material. This has been ascribed to a sampling artifact where biopsies are (i) either too small to allow formal mitotic figure counting or (ii) not necessarily taken form the proliferating tumor periphery. Herein, we propose a different explanation for this phenomenon. Biopsy and resection material of 52 invasive ductal carcinomas was studied. We counted mitotic figures in 10 representative high power fields and quantified MIB-1 immunohistochemistry by visual estimation, counting and image analysis. We found that mitotic figures were elevated by more than three-fold on average in resection specimen over biopsy material from the same tumors (20±6 vs 6±2 mitoses per 10 high power fields, P=0.008), and that this resulted in a relative diminution of post-metaphase figures (anaphase/telophase), which made up 7% of all mitotic figures in biopsies but only 3% in resection specimen (P<0.005). At the same time, the percentages of MIB-1 immunostained tumor cells among total tumor cells were comparable in biopsy and resection material, irrespective of the mode of MIB-1 quantification. Finally, we found no association between the size of the biopsy material and the relative increase of mitotic figures in resection specimen. We propose that the increase in mitotic figures in resection specimen and the significant shift towards metaphase figures is not due to a sampling artifact, but reflects ongoing cell cycle activity in the resected tumor tissue due to fixation delay. The dwindling energy supply will eventually arrest tumor cells in metaphase, where they are readily identified by the diagnostic pathologist. Taken together, we suggest that the rapidly fixed biopsy material better represents true tumor biology and should be privileged as predictive marker of putative response to cytotoxic chemotherapy.