Temperature-induced sex reversal is not responsible for sex-ratio distortions in grayling Thymallus thymallus or brown trout Salmo trutta.

On the basis of the experiments carried out over various years, it was concluded that (1) grayling Thymallus thymallus and brown trout Salmo trutta are resistant to temperature-induced sex reversal at ecologically relevant temperatures, (2) environmental sex reversal is unlikely to cause the persistent sex ratio distortion observed in at least one of the study populations and (3) sex-specific tolerance of temperature-related stress may be the cause of distorted sex ratios in populations of T. thymallus or S. trutta.

Consumer Advisory Bulletin, How to Deal With Credit Card Offers, October 2009

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DNA-DNA interactions in bacteriophage capsids are responsible for the observed DNA knotting.

Recent experiments showed that the linear double-stranded DNA in bacteriophage capsids is both highly knotted and neatly structured. What is the physical basis of this organization? Here we show evidence from stochastic simulation techniques that suggests that a key element is the tendency of contacting DNA strands to order, as in cholesteric liquid crystals. This interaction favors their preferential juxtaposition at a small twist angle, thus promoting an approximately nematic (and apolar) local order. The ordering effect dramatically impacts the geometry and topology of DNA inside phages. Accounting for this local potential allows us to reproduce the main experimental data on DNA organization in phages, including the cryo-EM observations and detailed features of the spectrum of DNA knots formed inside viral capsids. The DNA knots we observe are strongly delocalized and, intriguingly, this is shown not to interfere with genome ejection out of the phage.

Consumer Advisory Bulletin; Tips for Buying a Used Car, November 2009

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Consumer Advisory Bulletin; Consumer Tips for Holiday Shoppers, December 2009

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Consumer Advisory Bulletin; Beware of “Foreclosure Rescue Scams, January 2010

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Consumer Advisory Bulletin; Beware of Avoid Rapid Tax-Refund Loans, February 2010

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Consumer Advisory Bulletin; New Protections for Credit Card Consumers, March 2010

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Consumer Advisory Bulletin; The U.S. Census;Be Counted, but Don’t be Cheated, April 2010

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Shedding light on proteolytic cleavage of CD44: the responsible sheddase and functional significance of shedding.

CD44 is the major cell-surface receptor for hyaluronan, which is implicated in cell-cell and cell-matrix adhesion, cell migration, and signaling. Studies have shown that CD44-dependent migration requires CD44 to be shed from the cell surface and that matrix metalloproteinase-mediated cleavage may provide an underlying mechanism. However, the full spectrum of proteases that may participate in CD44 shedding has yet to be defined. In this issue, Anderegg et al. demonstrate that ADAM10, but not ADAM17 or MMP14, mediates constitutive shedding of CD44 in human melanoma cells and that knockdown of ADAM10 blocks the antiproliferative activity of the soluble proteolytic cleavage product of CD44.

Consumer Advisory Bulletin; Prevent Home Repair Scams and Disputes, May 2010

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Consumer Advisory Bulletin; Beware of “Debt Settlement” Companies, June 2010

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Consumer Advisory Bulletin; Beware of “Free Trial Offers”, July 2010

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Consumer Advisory Bulletin, Credit Card Offers: What You Need to Know, August 2010

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Consumer Advisory Bulletin, Wire Fraud Targets Your Mind & Your Money!, September 2010

The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments. This record is about: Wire Fraud Targets Your Mind & Your Money