Vista del arco de triunfo y de la ciudad de Cabanes [Material gráfico] =Vue de l'arc de triomphe et de la ville de Cabanes=View of the triumphal Arch and the city of Cabanes

Estampado en la misma hoja con: "Detalles geometrales del Arco de Cabanes"

Vista de la puerta de Serranos de Valencia [Material gráfico] =Vue de la Porte de Serranos à Valence=View of the Gate of Serranos at Valencia

Datos de publicación tomados de la obra a la que pertenece

Vista de la Alameda, paseo de Valencia [Material gráfico] =Vue de la Alameda de Valence=View of the Alameda, apublic coalk at Valencia

Datos de publicación tomados de la obra a la que pertenece

Vista interior de la Lonja de Valencia [Material gráfico] =Vue intérieure de la Bourse de Valence=Interiour view of the Exchange at Valencia

Estampado en la misma hoja con: "Plano de la Lonja de Valencia"

Vista de la entrada de un convento en la Alameda de Valencia [Material gráfico] =Vue de l'entrée d'un couvent sur la Alameda à Valence=View of the entrance of a convent upon the Alameda at Valencia

Datos de publicación tomados de la obra a la que pertenece

View of the prating rock somerseshire [Material gráfico]

Alcance y contenido: Descripción: vista de paisaje inglés

Vista del salto de Chulilla [Material gráfico] = Vue du saut de Chulilla = View of the leap of Chulilla

Datos de publicación tomados de la obra a la que pertenece

Segunda vista del teatro de Sagunto [Material gráfico] = Seconde vue du théâtre de Sagonte = Second view of the theatre of Sagonta

Estampado junto a: "Vista de la Ciudadela"

Vista de la Ciudadela [Material gráfico] = Vue de la Citadelle = View of the Citadel

Estampado junto a: "Segunda vista del teatro de Sagunto"

Vista general del Teatro de Sagunto [Material gráfico] = Vue generale du Theatre de Sagonte = General view of the Theatre of Sagonta

Resumen: Descripción: vista general del Teatro de Sagunto desde el exterior, se observan las gradas

Surrogate-based optimization of the nose shape of a train subjected to crosswind

Optimización multi-objetivo frente a varias direcciones del viento incidente del testero de un tren de alta velocidad

Vista de la puerta de entrada de la fortaleza de Xativa [ [Material gráfico]= Vue de la porte d'entrèe de la forteresse de Xativa, et d'une partie de la ville de St. Philippe = View of the great gate of the fortress of Xativa, and of a part of the town of St. Philip

Datos de publicación tomados de la obra a la que pertenece

A Physicalist View Of The Passion Of Christ

My project in this paper is to provide a plausible idea of Christ’s suffering and death in terms of a theory of the human person. More specifically, I want to contrast two major theories of the person-body relation. One is dualism. Dualism is the view that a human person is composed of two substances, that is, a soul and a body, and he (strictly speaking) is identical with the soul. On the other hand, physicalism is the view that a human person is numerically identical with his biological body. I will argue that dualism is not successful in explaining Christ’s passion for some reasons. Rather, physicalism, as I shall argue, provides a better explanation of how Christ’s physical suffering and death are real just like everyone else’s, so it is philosophically and theologically more plausible than dualism.

Mechanism-based inhibition of the melatonin rhythm enzyme: Pharmacologic exploitation of active site functional plasticity

Serotonin N-acetyltransferase is the enzyme responsible for the diurnal rhythm of melatonin production in the pineal gland of animals and humans. Inhibitors of this enzyme active in cell culture have not been reported previously. The compound N-bromoacetyltryptamine was shown to be a potent inhibitor of this enzyme in vitro and in a pineal cell culture assay (IC50 ≈ 500 nM). The mechanism of inhibition is suggested to involve a serotonin N-acetyltransferase-catalyzed alkylation reaction between N-bromoacetyltryptamine and reduced CoA, resulting in the production of a tight-binding bisubstrate analog inhibitor. This alkyltransferase activity is apparently catalyzed at a functionally distinct site compared with the acetyltransferase activity active site on serotonin N-acetyltransferase. Such active site plasticity is suggested to result from a subtle conformational alteration in the protein. This plasticity allows for an unusual form of mechanism-based inhibition with multiple turnovers, resulting in “molecular fratricide.” N-bromoacetyltryptamine should serve as a useful tool for dissecting the role of melatonin in circadian rhythm as well as a potential lead compound for therapeutic use in mood and sleep disorders.

Structure-based assignment of the biochemical function of a hypothetical protein: A test case of structural genomics

Many small bacterial, archaebacterial, and eukaryotic genomes have been sequenced, and the larger eukaryotic genomes are predicted to be completely sequenced within the next decade. In all genomes sequenced to date, a large portion of these organisms’ predicted protein coding regions encode polypeptides of unknown biochemical, biophysical, and/or cellular functions. Three-dimensional structures of these proteins may suggest biochemical or biophysical functions. Here we report the crystal structure of one such protein, MJ0577, from a hyperthermophile, Methanococcus jannaschii, at 1.7-Å resolution. The structure contains a bound ATP, suggesting MJ0577 is an ATPase or an ATP-mediated molecular switch, which we confirm by biochemical experiments. Furthermore, the structure reveals different ATP binding motifs that are shared among many homologous hypothetical proteins in this family. This result indicates that structure-based assignment of molecular function is a viable approach for the large-scale biochemical assignment of proteins and for discovering new motifs, a basic premise of structural genomics.