Subconjunctival Injection of XG-102, a JNK Inhibitor Peptide, in Patients with Intraocular Inflammation: A Safety and Tolerability Study.

Abstract Purpose: We aimed to investigate the safety, tolerability, and systemic diffusion of a single escalating dose of XG-102 (a 31-D-amino-acid peptide inhibiting JNK pathway activation), administered subconjunctivally in the treatment of post-surgery or post-trauma intraocular inflammation. Methods: This is a dose-escalating, tolerance Phase Ib study. Twenty patients with post-surgery or post-traumatic intraocular inflammation were assigned to 1 of the 4 dose escalating (45, 90, 450, or 900 μg XG-102) groups of 5 patients each. Patients were evaluated at 24, 48 h, 8, and 28 days following the administration of XG-102, including laboratory tests, standard eye examinations, vital signs, and occurrence of adverse events. A single plasma quantification of XG-102 was performed 30 min after administration, according to previous pharmacokinetics studies performed on volunteers. Results: A total of 17 non-serious adverse events, considered unrelated to the study treatment, were reported for 10 patients. The adverse event incidence was not related to the drug dose. All patients experienced a decrease in intraocular inflammation as of 24 h post-administration and this decrease was sustained up to 28 days thereafter. No patient required local injection or systemic administration of corticoids following the administration of XG-102. XG-102 was undetectable in the first 3 dose groups. In the fourth-dose group (900 μg) the XG-102 plasma levels were above the limit of detection for 3 patients and above the limit of quantification for 1 patient. Conclusions: In this first clinical trial using XG-102, administered as a single subconjunctival injection as adjunct therapy, in patients with recent post-surgery or post-trauma intraocular inflammation is safe and well tolerated. Further studies are required to evaluate its efficacy.

Reliure de : Georgii Agricolae de Mensuris et ponderibus Romanorum atque Graecorum lib. V. De externis mensuris et ponderibus lib. II... De restituendis ponderibus atque mensuris lib. I. De precio metallorum et monetis lib. III

Numérisation partielle de reliure

Reliure de : Georgii Agricolae de Ortu et causis subterraneorum lib. V. De natura eorum quae effluunt ex terra lib. IIII. De natura fossilium lib. X. De veteribus et novis metallis lib. II. Bermannus, sive de re metallica dialogus. Interpretatio germanica vocum rei metallicae...

Numérisation partielle de reliure

Reliure de : Georgii Agricolae de Re metallica libri XII, quibus officia, instrumenta, machinae ac omnia... ad metallicam spectantia non modo... describuntur, sed et per effigies... ob oculos ponuntur... Ejusdem de animantibus subterraneis liber...

Numérisation partielle de reliure

Ex XIIII. T. Livii Decadibus. Prima, tertia, quarta, in qua praeter fragmenta III, & X libri, quae in Germania nuper reperta, hic etiam continentur, multa adulterina expunximus, multa vera recepimus, quae in aliis non habentur. Epitome singulorum librorum XIIII Decadum. Historia omnium XIIII Decadum in compendium redacta ab L. Floro. Polybii lib. V de rebus Romanis latinitate donati à Nicolao Perotto. Index copiosissimus rerum omnium memorabilium...

[Histoire romaine (latin). 1518-1533]

Ex XIIII. T. Livii Decadibus. Prima, tertia, quarta, in qua praeter fragmenta III, & X libri, quae in Germania nuper reperta, hic etiam continentur, multa adulterina expunximus, multa vera recepimus, quae in aliis non habentur. Epitome singulorum librorum XIIII Decadum. Historia omnium XIIII Decadum in compendium redacta ab L. Floro. Polybii lib. V de rebus Romanis latinitate donati à Nicolao Perotto. Index copiosissimus rerum omnium memorabilium...

[Histoire romaine (latin). 1518-1533]

Joannis Joviani Pontani Opera omnia, soluta oratione composita Nomina librorum qui in hisse tribus partibus continentur, à tergo hujus paginae notatae reperiuntur

Comprend : Centum Ptolemaei Sententiae ad Syrum fratrem a Pontano è graeco in latinum tralatae, atque expositae

Joannis Joviani Pontani Opera omnia, soluta oratione composita Nomina librorum qui in hisse tribus partibus continentur, à tergo hujus paginae notatae reperiuntur

Comprend : Centum Ptolemaei Sententiae ad Syrum fratrem a Pontano è graeco in latinum tralatae, atque expositae

Example-based support vector machine for drug concentration analysis

Machine learning has been largely applied to analyze data in various domains, but it is still new to personalized medicine, especially dose individualization. In this paper, we focus on the prediction of drug concentrations using Support Vector Machines (S VM) and the analysis of the influence of each feature to the prediction results. Our study shows that SVM-based approaches achieve similar prediction results compared with pharmacokinetic model. The two proposed example-based SVM methods demonstrate that the individual features help to increase the accuracy in the predictions of drug concentration with a reduced library of training data.

[Illustration de Pantagrueline prognostication certaine, véritable et infalible pour l'an mile DXXXIII.] / François Rabelais, aut. du texte

Comprend : [Fig au titre : devins, savants et astrologues.] [Cote : microfilm R 9553]

[Illustrations de Pantagruel, roy des Dipsodes, restitué à son naturel, avec des faictz et prouesses espoventables composez par feu M.Alcofribas, abstracteur de quinte essence.] / François Rabelais, aut. du texte

Comprend : [Fig. au Prologue de l'auteur, f.2]. [Cote : microfilm R 9849] ; [Fig. au chap. II, f.10 :] De la nativité du très redoubté Pantagruel. [Cote : microfilm R 9849] ; [Fig. au chap. V, f.18 :] Des faictz du noble Pantagruel en son jeune âge. [Cote : microfilm R 9849] ; [Fig. au chap. IX, f.35 intitulé :] Comment Pantagruel trouva Panurge lequel il ayma toute sa vie. [représentant Panurge et sa Dame de Paris]. [Cote : microfilm R 9849] ; [Fig. au chap. XI en reg. f.45 :] Comment les seigneurs de Baisecul et Bume vesne plaidoient devant Pantagruel sans advocatz.. [Cote : microfilm R 9849] ; [Fig. au chap. XII, f.48 :] Comment le seigneur de Bume vesne plaidoie davant Pantagruel. [Cote : microfilm R 9849] ; [Fig au chap. XIII, f.52 :] Comment Pantagruel donna sentence sus le différent des deux seigneurs. [Cote : microfilm R 9849] ; [Fig au chap. XXI, f.86 :] Comment Panurge feut amoureux d'une hauste dame de Paris. [Cote : microfilm R 9849] ; [Fig au chap. XXV, f.101 :] Comment Pantagruel et ses compaignons estoient fachez de manger de la chair salée, et comme Carpalim alla chasser pour avoir de la venaison. [Cote : microfilm R 9849]