The Shrimp Export Boom and Small-Scale Fishermen in Myanmar

This paper examines the impact of the recent shrimp export boom in Myanmar on the economic state of small-scale fishermen. Results indicate that there has been an active increase in shrimp fishing stimulated by expanding export demand. With this, the income of shrimp fishermen has increased dramatically in the past 10 years. However, future prospects appear gloomy due to the possibility of over exploitation of shrimp resources.

Platforms, network effects and small business dynamics in China : case study of the Shanzhai cell phone industry

This paper seeks to argue the significance of platforms on emerging markets through a case study of the Shanzhai cell phone industry in Shenzhen, China. In this industry, value chains are being driven by both the technology platforms and the market platforms. The former include MTK baseband chipset, and so-called Shared PCBA and Shared Mould. The latter include the North Huaqiang Market and the Purchasing and Money Platform. Technology platforms greatly reduced the technological barriers to entry for independent design houses and system integrators, while market platforms markedly improved their poor marketing and purchasing abilities. Due to factors such as social networks, supporting industries, informality and platform governance, strong network effects have been exhibited in the two types of platforms, which have not only fostered numerous start-ups, but have also led to effective exploitation of emerging markets.

Hydration of C3S, C2S and their Blends. Micro- and Nanoscale Characterization

This study forms part of wider research conducted under a EU 7 th Framework Programme (COmputationally Driven design of Innovative CEment-based materials or CODICE). The ultimate aim is the multi-scale modelling of the variations in mechanical performance in degraded and non-degraded cementitious matrices. The model is being experimentally validated by hydrating the main tri-calcium silicate (T1-C3S) and bi-calcium silicate (β-C2S), phases present in Portland cement and their blends. The present paper discusses micro- and nanoscale studies of the cementitious skeletons forming during the hydration of C3S, C2S and 70 % / 30 % blends of both C3S/C2S and C2S/C3S with a water/cement ratio of 0.4. The hydrated pastes were characterized at different curing ages with 29 Si NMR, SEM/TEM/EDS, BET, and nanoindentation. The findings served as a basis for the micro- and nanoscale characterization of the hydration products formed, especially C-S-H gels. Differences were identified in composition, structure and mechanical behaviour (nanoindentation), depending on whether the gels formed in C3S or C2S pastes. The C3S gels had more compact morphologies, smaller BET-N2 specific surface area and lesser porosity than the gels from C2S-rich pastes. The results of nanoindentation tests appear to indicate that the various C-S-H phases formed in hydrated C3S and C2S have the same mechanical properties as those formed in Portland cement paste. Compared to the C3S sample, the hydrated C2S specimen was dominated by the loose-packed (LP) and the low-density (LD) C-S-H phases, and had a much lower content of the high density (HD) C-S-H phase

The role of secretion systems and small molecules in soft-rot enterobacteriaceae pathogenicity

Soft-rot Enterobacteriaceae (SRE), which belong to the genera Pectobacterium and Dickeya, consist mainly of broad host-range pathogens that cause wilt, rot, and blackleg diseases on a wide range of plants. They are found in plants, insects, soil, and water in agricultural regions worldwide. SRE encode all six known protein secretion systems present in gram-negative bacteria, and these systems are involved in attacking host plants and competing bacteria. They also produce and detect multiple types of small molecules to coordinate pathogenesis, modify the plant environment, attack competing microbes, and perhaps to attract insect vectors. This review integrates new information about the role protein secretion and detection and production of ions and small molecules play in soft-rot pathogenicity.

From transparency to performance? Exploring how and why companies implement sustainability reporting practices.

Esta tesis se centra en el estudio de la implementación de prácticas de reporte de sostenibilidad (o RSC) en las empresas europeas. Estas prácticas han adquirido una relevancia notable a lo largo de los últimos 20 años, siendo utilizadas actualmente por el 93% de las 250 mayores empresas a nivel mundial y por más de 8000 organizaciones en total (de acuerdo a la base de datos de Global Reporting Initiative). Hasta la fecha, el considerable volumen de estudios existentes sobre las prácticas de reporte a nivel corporativo ha permitido caracterizar la influencia de una serie de factores externos (como la presión social o el comportamiento de organizaciones similares) a la hora de adoptar estas prácticas. Sin embargo, se dispone de mucho menos conocimiento respecto a las características internas que influyen en esta decisión, así como a la influencia de ambas causas (externas e internas) en la manera que el reporte se implementa una vez adoptado. Por tanto, esta tesis se centra en abordar estos dos aspectos. Para ello, se ha generado un marco conceptual que permite integrar ambas explicaciones para la adopción del reporte, combinando teorías institucionales (centradas en la influencia de fuerzas externas) y teorías organizativas (centradas en la eficiencia de una práctica a nivel de compañía). De manera análoga al ámbito de la RSC, en el cual existe una diversidad de contribuciones que reconocen la importancia de los factores externos y los factores internos (estratégicos) a la hora de impulsar estas prácticas, el marco conceptual generado tiene por objetivo propiciar un entendimiento más completo de las prácticas de reporte a nivel de compañía. De forma adicional al marco conceptual se han formulado también una serie de hipótesis específicas que relacionan la existencia de determinantes externos e internos y las distintas estrategias de implementación del reporte en cada organización.

A ANÁLISE DAS CAPACIDADES DE SOBREVIVÊNCIA DE PEQUENOS NEGÓCIOS NAS CIDADES DE ITANHAÉM E MONGAGUÁ: ESTUDO MULTICASO DE PEQUENAS EMPRESAS

O presente trabalho traz uma análise das capacidades de sobrevivência de três micro e pequenas empresas (MPEs) do ramo alimentício de doces de banana, estabelecidas na Região Metropolitana da Baixada Santista, especificamente nas cidades de Itanhaém e Mongaguá. Essas capacidades se construíram fundamentadas em dois pressupostos: efeito do gestor e o efeito da localidade, que podem ser determinantes para a sobrevivência e o desempenho de MPEs. A pesquisa tem por objetivo geral identificar as características do gestor e os fatores da localidade que influenciam a sobrevivência das três MPEs estudadas. Para alcançar o objetivo geral foram traçados os seguintes objetivos específicos: identificar as características da gestão que foram propulsoras da sobrevivência das três MPEs estudadas; identificar os recursos da localidade que foram propulsores à sobrevivência das três MPEs; verificar a existência de outros fatores da gestão e da localidade que possam ter influenciado a sobrevivência das MPEs no longo prazo. O estudo teve como expectativa contribuir para o aprofundamento da reflexão sobre o tema concernente às capacidades de sobrevivência dos pequenos negócios. A pesquisa bibliográfica esteve centrada no encadeamento de tópicos teóricos de forma a construir fundamentos necessários sobre as influências do gestor e da localidade na sobrevivência das pequenas empresas, noções necessárias para se atingir o objetivo geral. Para alcançar os objetivos propostos, a investigação, de caráter descritivo e indutivo, foi desenvolvida por meio de estudo multicaso, compreendendo pesquisa documental, observações e entrevistas semi-estruturadas, preliminar e de profundidade, tendo como sujeitos os gestores, os funcionários, os fornecedores e os clientes das três MPEs. Os resultados indicam que há fatores importantes do efeito gestor e do efeito localidade influenciando a sobrevivência das empresas locus da pesquisa. Os resultados apontaram fatores como acesso ao amplo mercado, atitude frente à tecnologia, a presença de laço forte e laço fraco, entre outros considerados importantes influenciadores na sobrevivência das empresas estudadas. Os resultados abrem perspectivas de estudos mais aprofundados que possam proporcionar e criar alternativas e programas para melhorar o desempenho e a sobrevivência das MPEs.(AU)

A ANÁLISE DAS CAPACIDADES DE SOBREVIVÊNCIA DE PEQUENOS NEGÓCIOS NAS CIDADES DE ITANHAÉM E MONGAGUÁ: ESTUDO MULTICASO DE PEQUENAS EMPRESAS

O presente trabalho traz uma análise das capacidades de sobrevivência de três micro e pequenas empresas (MPEs) do ramo alimentício de doces de banana, estabelecidas na Região Metropolitana da Baixada Santista, especificamente nas cidades de Itanhaém e Mongaguá. Essas capacidades se construíram fundamentadas em dois pressupostos: efeito do gestor e o efeito da localidade, que podem ser determinantes para a sobrevivência e o desempenho de MPEs. A pesquisa tem por objetivo geral identificar as características do gestor e os fatores da localidade que influenciam a sobrevivência das três MPEs estudadas. Para alcançar o objetivo geral foram traçados os seguintes objetivos específicos: identificar as características da gestão que foram propulsoras da sobrevivência das três MPEs estudadas; identificar os recursos da localidade que foram propulsores à sobrevivência das três MPEs; verificar a existência de outros fatores da gestão e da localidade que possam ter influenciado a sobrevivência das MPEs no longo prazo. O estudo teve como expectativa contribuir para o aprofundamento da reflexão sobre o tema concernente às capacidades de sobrevivência dos pequenos negócios. A pesquisa bibliográfica esteve centrada no encadeamento de tópicos teóricos de forma a construir fundamentos necessários sobre as influências do gestor e da localidade na sobrevivência das pequenas empresas, noções necessárias para se atingir o objetivo geral. Para alcançar os objetivos propostos, a investigação, de caráter descritivo e indutivo, foi desenvolvida por meio de estudo multicaso, compreendendo pesquisa documental, observações e entrevistas semi-estruturadas, preliminar e de profundidade, tendo como sujeitos os gestores, os funcionários, os fornecedores e os clientes das três MPEs. Os resultados indicam que há fatores importantes do efeito gestor e do efeito localidade influenciando a sobrevivência das empresas locus da pesquisa. Os resultados apontaram fatores como acesso ao amplo mercado, atitude frente à tecnologia, a presença de laço forte e laço fraco, entre outros considerados importantes influenciadores na sobrevivência das empresas estudadas. Os resultados abrem perspectivas de estudos mais aprofundados que possam proporcionar e criar alternativas e programas para melhorar o desempenho e a sobrevivência das MPEs.(AU)

NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines

Pulmonary neuroepithelial bodies (NEB) are widely distributed throughout the airway mucosa of human and animal lungs. Based on the observation that NEB cells have a candidate oxygen sensor enzyme complex (NADPH oxidase) and an oxygen-sensitive K+ current, it has been suggested that NEB may function as airway chemoreceptors. Here we report that mRNAs for both the hydrogen peroxide sensitive voltage gated potassium channel subunit (KH2O2) KV3.3a and membrane components of NADPH oxidase (gp91phox and p22phox) are coexpressed in the NEB cells of fetal rabbit and neonatal human lungs. Using a microfluorometry and dihydrorhodamine 123 as a probe to assess H2O2 generation, NEB cells exhibited oxidase activity under basal conditions. The oxidase in NEB cells was significantly stimulated by exposure to phorbol esther (0.1 μM) and inhibited by diphenyliodonium (5 μM). Studies using whole-cell voltage clamp showed that the K+ current of cultured fetal rabbit NEB cells exhibited inactivating properties similar to KV3.3a transcripts expressed in Xenopus oocyte model. Exposure of NEB cells to hydrogen peroxide (H2O2, the dismuted by-product of the oxidase) under normoxia resulted in an increase of the outward K+ current indicating that H2O2 could be the transmitter modulating the O2-sensitive K+ channel. Expressed mRNAs or orresponding protein products for the NADPH oxidase membrane cytochrome b as well as mRNA encoding KV3.3a were identified in small cell lung carcinoma cell lines. The studies presented here provide strong evidence for an oxidase-O2 sensitive potassium channel molecular complex operating as an O2 sensor in NEB cells, which function as chemoreceptors in airways and in NEB related tumors. Such a complex may represent an evolutionary conserved biochemical link for a membrane bound O2-signaling mechanism proposed for other cells and life forms.

Galectin-4 and Small Intestinal Brush Border Enzymes Form Clusters

Detergent-insoluble complexes prepared from pig small intestine are highly enriched in several transmembrane brush border enzymes including aminopeptidase N and sucrase-isomaltase, indicating that they reside in a glycolipid-rich environment in vivo. In the present work galectin-4, an animal lectin lacking a N-terminal signal peptide for membrane translocation, was discovered in these complexes as well, and in gradient centrifugation brush border enzymes and galectin-4 formed distinct soluble high molecular weight clusters. Immunoperoxidase cytochemistry and immunogold electron microscopy showed that galectin-4 is indeed an intestinal brush border protein; we also localized galectin-4 throughout the cell, mainly associated with membraneous structures, including small vesicles, and to the rootlets of microvillar actin filaments. This was confirmed by subcellular fractionation, showing about half the amount of galectin-4 to be in the microvillar fraction, the rest being associated with insoluble intracellular structures. A direct association between the lectin and aminopeptidase N was evidenced by a colocalization along microvilli in double immunogold labeling and by the ability of an antibody to galectin-4 to coimmunoprecipitate aminopeptidase N and sucrase-isomaltase. Furthermore, galectin-4 was released from microvillar, right-side-out vesicles as well as from mucosal explants by a brief wash with 100 mM lactose, confirming its extracellular localization. Galectin-4 is therefore secreted by a nonclassical pathway, and the brush border enzymes represent a novel class of natural ligands for a member of the galectin family. Newly synthesized galectin-4 is rapidly “trapped” by association with intracellular structures prior to its apical secretion, but once externalized, association with brush border enzymes prevents it from being released from the enterocyte into the intestinal lumen.

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

Somatic mutation accumulation has been implicated as a major cause of cancer and aging. By using a transgenic mouse model with a chromosomally integrated lacZ reporter gene, mutational spectra were characterized at young and old age in two organs greatly differing in proliferative activity, i.e., the heart and small intestine. At young age the spectra were nearly identical, mainly consisting of G·C to A·T transitions and 1-bp deletions. At old age, however, distinct patterns of mutations had developed. In small intestine, only point mutations were found to accumulate, including G·C to T·A, G·C to C·G, and A·T to C·G transversions and G·C to A·T transitions. In contrast, in heart about half of the accumulated mutations appeared to be large genome rearrangements, involving up to 34 centimorgans of chromosomal DNA. Virtually all other mutations accumulating in the heart appeared to be G·C to A·T transitions at CpG sites. These results suggest that distinct mechanisms lead to organ-specific genome deterioration and dysfunction at old age.

Textural Characterization of Micro- and Mesoporous Carbons Using Combined Gas Adsorption and n-Nonane Preadsorption

Porous carbon and carbide materials with different structures were characterized using adsorption of nitrogen at 77.4 K before and after preadsorption of n-nonane. The selective blocking of the microporosity with n-nonane shows that ordered mesoporous silicon carbide material (OM-SiC) is almost exclusively mesoporous whereas the ordered mesoporous carbon CMK-3 contains a significant amount of micropores (25%). The insertion of micropores into OM-SiC using selective extraction of silicon by hot chlorine gas leads to the formation of ordered mesoporous carbide-derived carbon (OM-CDC) with a hierarchical pore structure and significantly higher micropore volume as compared to CMK-3, whereas a CDC material from a nonporous precursor is exclusively microporous. Volumes of narrow micropores, calculated by adsorption of carbon dioxide at 273 K, are in linear correlation with the volumes blocked by n-nonane. Argon adsorption measurements at 87.3 K allow for precise and reliable calculation of the pore size distribution of the materials using density functional theory (DFT) methods.

Structural Characterization of Micro- and Mesoporous Carbon Materials Using In Situ High Pressure 129Xe NMR Spectroscopy

In situ high pressure 129Xe NMR spectroscopy in combination with volumetric adsorption measurements were used for the textural characterization of different carbon materials with well-defined porosity including microporous carbide-derived carbons, ordered mesoporous carbide-derived carbon, and ordered mesoporous CMK-3. Adsorption/desorption isotherms were measured also by NMR up to relative pressures close to p/p0 = 1 at 237 K. The 129Xe NMR chemical shift of xenon adsorbed in porous carbons is found to be correlated with the pore size in analogy to other materials such as zeolites. In addition, these measurements were performed loading the samples with n-nonane. Nonane molecules preferentially block the micropores. However, 129Xe NMR spectroscopy proves that the nonane also influences the mesopores, thus providing information about the pore system in hierarchically structured materials.