Monitieteinen ja tieteidenvälinen muisti : Memory from transdisciplinary perspectives

Ajankohtaista

Armeliaisuuslaitoksesta kuriositeetiksi : Kivennavan Lintulan nunnaluostarin miljöön muotoutuminen 1800-luvun lopulta 1930-luvulle

Zusammenfassung: Von einer Wohltätigkeitseinrichtung zur Kuriosität : wie sich das Milieu des Nonnenklosters Lintula in Kivinebb in der Zeit vom Ende des 19. Jahrhunderts bis in die 1930er Jahre wandelte

Vanhustyöntekijät - näkemyksiä vanhustyöstä ja sen kehittämisestä

Summary: The professional caregivers of the elderly in Satakunta

Paroxetine use in pregnancy and cardiovascular defects

Background: Paroxetine (Paxil,) is an SSRI, used for thetreatment of depression, obsessive compulsive disorder,anxiety disorders and premenstrual dysphoria. Untilrecently, no studies had associated SSRIs as a group withan increased risk for major malformations above the 1%-3% baseline rate. However, in the past year, several studiesnoted specifically, an increase risk of cardiovascular defectsassociated with paroxetine, compared to other antidepressantswithin its class.Objectives: To determine whether paroxetine increases therisk of cardiovascular defects in infants of women exposedduring the first trimester of pregnancy.Methods: We collected prospectively ascertained cases ofinfants from Teratogen Information Services throughout theworld, exposed to paroxetine in the first trimester of pregnancyand compared them to a non-exposed Motheriskcohort.We also contacted the authors of data base studies thathad been published on antidepressants as a class, to determinehow many of these women had been exposed to paroxetineand the rates of cardiovascular defects in their infants.Results: We were able to ascertain the outcomes of 1177infants from 9 services. The rate of heart defects in the paroxetineparoxetinegroup was 0.8% versus 0.7% non-exposed group.The combined rate in the data base studies was 1.5%.Conclusions: Paroxetine does not appear to be associated withan increase risk for cardiovascular defects following use inpregnancy, as the incidence in more than 3000 infants was wellwithin the population incidence of approximately 1%.

Koherenssi-käsitys ja epäkypsät defenssit

Summary: Sense of coherence and immature defenses