768 resultados para Mallette, Rick


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While there have been many attempts at comparisons of construction performance over the past 50 years, the results have generally been inconclusive and/or contradictory.

Such comparisons are of great interest to industry, governments and theorists alike but there is little agreement as to how they are best done. A variety of methodologies have been used, however, the lack of satisfactory outcomes has been due largely to one factor, the lack of a truly reliable method for comparing construction costs in different currencies

Exchange rates are recognised as being unsuitable, and while purchasing power parity (PPP) has a long history, the method still has many critics. In addition, the nature of the building industry and its products makes the establishment of reliable construction PPPs very difficult. Both the UN’s International Comparison Program (ICP) and the European Union gather data for the production of construction-specific PPP indices, but neither body publishes them, as there is too much doubt about their reliability.

New approaches are being developed and some are soon to be trialled. This paper looks at the problems, describes and discusses some new approaches, and assesses their potential.

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This book provides comprehensive coverage of issues that facility managers in the property industry need to understand and apply in the pursuit of value for money over the life span of built facilities. The authors introduce the fast-growing discipline of facility management, examine the core competencies that facility managers should possess and study different contemporary drivers of change. The book emphasises the need to consider facilities management issues at the pre-design stage of the construction process, rather than only when the building is completed, in order to maximise value for money.

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Australian and UK Building Codes undergo revision to improve the health and safety standards in the built environment and reflect wider social and technological changes. In the 1990s both countries changed to the option for designers to provide alternative solutions, where designers provide calculations to demonstrate that the codes are satisfied but not through the traditional deemed to satisfy route. Other social and legislative changes have had an impact on the profession. In the UK the Institute of Building Control, the equivalent of the Australian Institute of Building Surveyors responded by joining the Royal Institution of the Chartered Surveyors. Thus it has become part of the largest surveying professional body, what does that mean for the profession? This paper compares the Australian and UK professions and looks at some of the issues affecting their future direction.

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Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r2 > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.