A segurança da dependência e os desafios da soberania: expansão da agroindústria canavieira e a geografia do abastecimento alimentar no município de Tupi Paulista/SP

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A linguagem do espaço-tempo

This study sought to offer a didactic approach in relation with the fundamentals of cubism temporal space derived of the theory of relativity, since the exhaustive character on the matter considering the need for a more consistent explanation of the physics Einsteinium postulates which is not an exactly research theme, despite being at its heart.

Uma análise do ensino de língua inglesa por meio do uso das Tecnologias Digitais da Informação e Comunicação

Pós-graduação em Educação - FFC

Referenciação multimodal: a construção de objetos-de-discurso no jornal impresso Folha de S. Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Pedagogia histórico-crítica e alfabetização: elementos para uma perspectiva histórico-crítica do ensino da leitura e da escrita

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O uso de MC em uma abordagem Socio-interacionista no ensino de Física

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Desenvolvimento da linguagem oral em crianças afastadas da família de origem

For a complete development of oral language it's necessary the development of genetic roots of thought and utterance postulates by Vygotsky, yet the meditation of adult and the influence social and cultural that is around the child. In cases of children moved away from their birth family by judicial ways because of neglect there, is a new modality of refuge in Brazil, that is the home refuge, which is the object of our research. The present study shows an investigation about the development of speech in a child that was moved away from his birth family and forwarded to Foster Family to comprehend the contributions and activities that help in child development. The research was performed through an approach of qualitative interpretation of bibliographic type and area type. The data analysis allowed us conclude the new social and cultural way that the watched child was inserted helps in his development in a significant way enabling a qualitative jump in speech and psychic functions phase

Resiliência, educação e escola: um balanço das produções científicas de 2000 a 2013

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento da linguagem oral em crianças afastadas da família de origem

For a complete development of oral language it's necessary the development of genetic roots of thought and utterance postulates by Vygotsky, yet the meditation of adult and the influence social and cultural that is around the child. In cases of children moved away from their birth family by judicial ways because of neglect there, is a new modality of refuge in Brazil, that is the home refuge, which is the object of our research. The present study shows an investigation about the development of speech in a child that was moved away from his birth family and forwarded to Foster Family to comprehend the contributions and activities that help in child development. The research was performed through an approach of qualitative interpretation of bibliographic type and area type. The data analysis allowed us conclude the new social and cultural way that the watched child was inserted helps in his development in a significant way enabling a qualitative jump in speech and psychic functions phase

Resiliência, educação e escola: um balanço das produções científicas de 2000 a 2013

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Inconsistent-tolerant base revision through Argument Theory Change

Reasoning and change over inconsistent knowledge bases (KBs) is of utmost relevance in areas like medicine and law. Argumentation may bring the possibility to cope with both problems. Firstly, by constructing an argumentation framework (AF) from the inconsistent KB, we can decide whether to accept or reject a certain claim through the interplay among arguments and counterarguments. Secondly, by handling dynamics of arguments of the AF, we might deal with the dynamics of knowledge of the underlying inconsistent KB. Dynamics of arguments has recently attracted attention and although some approaches have been proposed, a full axiomatization within the theory of belief revision was still missing. A revision arises when we want the argumentation semantics to accept an argument. Argument Theory Change (ATC) encloses the revision operators that modify the AF by analyzing dialectical trees-arguments as nodes and attacks as edges-as the adopted argumentation semantics. In this article, we present a simple approach to ATC based on propositional KBs. This allows to manage change of inconsistent KBs by relying upon classical belief revision, although contrary to it, consistency restoration of the KB is avoided. Subsequently, a set of rationality postulates adapted to argumentation is given, and finally, the proposed model of change is related to the postulates through the corresponding representation theorem. Though we focus on propositional logic, the results can be easily extended to more expressive formalisms such as first-order logic and description logics, to handle evolution of ontologies.

Localizability in de Sitter space

An analogue of the Newton-Wigner position operator is defined for a massive neutral scalar field in de Sitter space. The one-particle subspace of the theory, consisting of positive-energy solutions of the Klein-Gordon equation selected by the Hadamard condition, is identified with an irreducible representation of the de Sitter group. Postulates of localizability analogous to those written by Wightman for fields in Minkowski space are formulated on it, and a unique solution is shown to exist. Representations in both the principal and the complementary series are considered. A simple expression for the time evolution of the Newton-Wigner operator is presented.

Differential expression of HIF-1α in CD44+CD24-/low breast ductal carcinomas

Abstract Background Cancer stem cell (CSC) hypothesis postulates that tumors are maintained by a self-renewing CSC population that is also capable of differentiating into non-self-renewing cell populations that constitute the bulk of tumor. Stem cells renewal and differentiation can be directly influenced by the oxygen levels of determined tissues, probably by the reduction of oxidative DNA damage in hypoxic regions, thus leading to a friendlier microenvironment, regarding to clonal expansion and for resistance to chemotherapeutic regimens. Furthermore, there have been strong data indicating a pivotal role of hypoxic niche in cancer stem cells development. There are evidence that hypoxia could drive the maintenance of CSC, via HIF-1α expression, but it still to be determined whether hypoxia markers are expressed in breast tumors presenting CD44+CD24-/low immunophenotype. Methods Immunohistochemical analysis of CD44+CD24-/low expression and its relationship with hypoxia markers and clinical outcome were evaluated in 253 samples of breast ductal carcinomas. Double-immunolabeling was performed using EnVision Doublestain System (Dako, Carpinteria, CA, USA). Slides were then scanned into high-resolution images using Aperio ScanScope XT and then, visualized in the software Image Scope (Aperio, Vista, CA, USA). Results In univariate analysis, CD44+CD24-/low expression showed association with death due to breast cancer (p = 0.035). Breast tumors expressing CD44+CD24-/low immunophenotype showed relationship with HIF-1α (p = 0.039) and negativity for HER-2 (p = 0.013). Conclusion Considering that there are strong evidences that the fraction of a tumour considered to be cancer stem cells is plastic depending upon microenvironmental signals, our findings provide further evidence that hypoxia might be related to the worse prognosis found in CD44+CD24-/low positive breast tumors.

Mechanisms of cell senescence: p21 and DNA damage response in aging and longevity

Theory of aging postulates that aging is a remodeling process where the body of survivors progressively adapts to internal and external damaging agents they are exposed to during several decades. Thus , stress response and adaptation mechanisms play a fundamental role in the aging process where the capability of adaptating effects, certainly, also is related the lifespan of each individual. A key gene linking aging to stress response is indeed p21, an induction of cyclin-dependent kinase inhibitor which triggers cell growth arrest associated with senescence and damage response and notably is involved in the up-regulation of multiple genes that have been associated with senescence or implicated in age-related . This PhD thesis project that has been performed in collaboration with the Roninson Lab at Ordway Research Institute in Albany, NY had two main aims: -the testing the hypothesis that p21 polymorphisms are involved in longevity -Evaluating age-associated differences in gene expression and transcriptional response to p21 and DNA damage In the first project, trough PCR-sequencing and Sequenom strategies, we we found out that there are about 30 polymorphic variants in the p21 gene. In addition, we found an haplotpype located in -5kb region of the p21 promoter whose frequency is ~ 2 fold higher in centenarians than in the general population (Large-scale analysis of haplotype frequencies is currently in progress). Functional studies I carried out on the promoter highilighted that the ―centenarian‖ haplotype doesn’t affect the basal p21 promoter activity or its response to p53. However, there are many other possible physiological conditions in which the centenarian allele of the p21 promoter may potentially show a different response (IL6, IFN,progesterone, vitamin E, Vitamin D etc). In the second part, project #2, trough Microarrays we seeked to evaluate the differences in gene expression between centenarians, elderly, young in dermal fibroblast cultures and their response to p21 and DNA damage. Microarray analysis of gene expression in dermal fibroblast cultures of individuals of different ages yielded a tentative "centenarian signature". A subset of genes that were up- or downregulated in centenarians showed the same response to ectopic expression of p21, yielding a putative "p21-centenarian" signature. Trough RQ-PCR (as well Microarrays studies whose analysis is in progress) we tested the DNA damage response of the p21-centenarian signature genes showing a correlation stress/aging in additional sets of young and old samples treated with p21-inducing drug doxorubicin thus finding for a subset of of them , a response to stress age-related.

Charakterisierung von Arthropodenhämocyaninen

Verschiedene cDNA-Banken wurden erstellt, andere waren bereits vorhanden. Diese Expressionsbanken wurden mittels Antikörper- bzw. Sondenscreening auf Hämocyanin- bzw. bei den Insekten auch auf Hexamerinklone durchmustert. Dabei gelang es, diverse Hämocyaninunter-einheiten zu identifizieren und zu sequenzieren. Die erarbeiteten Sequenzen wurden im An-schluss für phylogenetische Studien benutzt. Es konnte hierbei gezeigt werden, dass die so-genannte „Tracheata-Hypothese“ immer unwahrscheinlicher wird. Diese geht von einer Schwestergruppenstellung der Hexapoda und der Myriapoda aus. Die hier gemachten Unter-suchungen widersprechen dieser Hypothese eindeutig. Die Ergebnisse stützen vielmehr die „Pancrustacea-Hypothese“. In den Stammbäumen sind die Crustaceenhämocyanine eindeutig in naher Verwandtschaft zu den paraphyletisch entstandenen Insektenhämocyaninen angeordnet. Ob die Crustaceen monophyletischen Ursprungs sind, kann nicht eindeutig beurteilt werden, es bestehen aber weiterhin begründete Zweifel. Die Myriapodenhämocyanine stehen in Schwestergruppenstellung zu den Crustaceen und den Insektenhämocyaninen. Dies weist auf ein gemeinsames Taxon der Mandibulata hin. Die systematische Stellung der Myriapoden innerhalb der Arthropoden kann allerdings nicht abschließend geklärt werden. Dazu ist eine weitergehende Aufklärung von Hämocyaninsequenzen in diesem Arthropodentaxon notwendig.