999 resultados para Ingredientes farmaceuticamente ativos


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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Pós-graduação em Medicina Veterinária - FMVZ

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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A presente invenção refere-se a extratos, frações ativas e/ou compostos isolados de Caseana sylvest ris. Adicionalmente, o presente pedido provê formulações farmacêuticas contendo os ditos ingredientes ativos e suas aplicações como medicamentos indicados no tratamento de distúrbios do trato gastrintestinal, preferencialmente, úlcera gastroduodenal.

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Processo de obtenção de componentes ativos de própolis no estado sólido realizado sem a utilização de etanol em seus extratos, possibilitando a obtenção destes elementos em seu estado sólido, facilitando assim seu manuseio, armazenamento, transporte e acondicionamento, sendo que para a obtenção de tais resultados, o presente processo utiliza-se de microencapsulação, que tem sido amplamente empregada com o objetivo de mascarar o sabor e o odor desagradáveis, de controlar a liberação, facilitando o cumprimento da posologia por parte do paciente e auxiliando na terapêutica, sendo que esta tecnologia também possui a propriedade de transformar formas farmacêuticas líquidas em sólidas, eliminando solventes indesejáveis e promovendo fácil manuseio.

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This study aimed to evaluate the potential of CH4 and CO2 in vitro production of soybean hulls, sunflower meal, corn, citrus pulp and corn silage. Four rumen-cannulated sheep were fed diets containing the evaluated ingredients at 40:60 forage:concentrate ratio. The gases produced by samples incubation were measured by injection into a gas chromatograph equipped with flame ionization detector. The experimental design was completely randomized with repeated measures, with three replicates for each evaluated food at four different periods. Under the experimental conditions, we verified different potential gas production among the ingredients. The citrus pulp meal was the ingredient with the greatest potential for CO2production. Corn silage and soybean hulls showed the greatest potential while citrus pulp and sunflower meal showed the least potential for CH4 production, when expressed in mL/g of degraded dry matter; therefore, they can be considered, among the evaluated ingredients, those with the lowest environmental impact.

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The castor bean (Ricinus communis L.) is a tropical oilseed species, and the oil extracted from its seeds is one of the most versatile oils in the nature, showing various industrial uses. Even though it is a rustic species, the castor bean is subjected to several diseases such as the gray mold, caused by the fungus Amphobotrys ricini. Genetic breeding would be the best alternative for the disease control, but a long time is required to obtain resistant cultivars. Thus, the use of control strategies based on chemical, alternative or biological methods shows viable in the short term. The aim of this study was to investigate gray mold control efficiency, in castor bean crop, using chemical, alternative and biological methods. The pathogen control efficiency was evaluated both in vitro and in vivo using fungicides, essential oils and biological control agents. As regards the in vitro inhibition of the pathogen mycelial growth, the best treatments with essential oils were those based on C. martini and C. zeylanicum at all five tested concentrations. For both oils, the average diameter of colonies was 0.7 cm against 4.79 cm for the control treatment. For the fungicides, at all four tested levels, the most efficient active ingredients were methyl tiophanate, carbendazim, tebuconazole and iprodione. The ED50 of these fungicides was <1uL/L, yielding 100% mycelial growth inhibition at all concentrations. As to the inhibition of A. ricini conidium germination, the fungicides tebuconazole and chlorotanolyl were the best at all tested concentrations, and the average of germinated conidia with these fungicides was 0.0 and 0.15%, respectively, against 100% for the control treatment. In the field, treatment with the fungicide iprodione was the best for the disease control when compared to biological and alternative treatments. Under field conditions, the average disease severity for the treatment with iprodione was 15.76% against 95.81% for the inoculated control.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Introduction: Among others things, ageing results in neuromuscular decrease. The physical activity practice may to influence positively the ageing process. Objective: To evaluate the flexibility and the level of pain on the sedentary and physically active elderly. Method: Forty-two elderly participated of this study, both male and female, (twenty-two physically active and twenty sedentary), over sixty years old and functionally capable to perform the evaluations suggested. They were submitted to tests of decrease in anterior flexion of the trunk, Stibor and Shoeber to evaluate the flexibility and then they signalized the level of pain on the analogic visual scale. The data obtained on the valuations has been analyzed utilizing the non-parametric statistic test Mann-Whitney, considering the level of significance of 5% (p<0,05), in order to compare the performance among the groups. Results: It has not been observed significant di- fferences among the groups referring to the tests Stibor and analogic visual scale. On Shoeber and FAT tests has been observed significant differences (p<0,05) among the groups, with a better performance to the active group. Conclusion: The physical activity practicing interfere on the mobility and on the flexibility of the elderly body segment.

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Introduction:The regular practice of physical activity is being used as a therapeutic resource to the elderly population, with the objective of reduction of the losses provoked by the growing old process. The home place (urban or rural) is still little explored in literature about your infl uence in the physical capacity of the elderly people. Objective: The aim of this study was to value and compare the quality of life, motion and functional capacity between physically active and sedentary elderly people, residents in the urban and rural area. Methods: Sixty people with age above 60 years old were valued, 20 physically active residents in the urban area (66,5 ± 4,32 years), 20 sedentary residents in the urban area (68,8± 7,24 years), 10 physically active residents in the rural area (64,4±2,46 years) and 10 sedentary residents in the rural area (68±5,78 years). It was realized the evaluation of the fl exibility (previous fl exon of the trunk), mobility (timed up and go test), a six-minute walk test and answered a quality of life’s questionnaire SF-36. To compare the results obtained by the two groups was used the Kruskal-Wallis test, and the signifi cant presence of the test was performed post hoc Newman-Keuls. The level of signifi cance used in statistical analysis was 5% (p<0,05).Results: It was observed that the physically active elderly people obtaine better performance on the six-minutes walk test. It wasn’t found difference in the mobility among the groups. In relation to the quality of life, the elderly residents in the rural area, were better in the component Vitally. In relation to the fl exibility the elderly residents in the urban area obtained the best results. So, we can conclude that the practice of physical activity realized by the volunteers contributed to a better functional capacity, observed by the biggest distance gone through on the walk test. The rural home place positively infl uenced the vitality control, while the fl exibility was worse presented in these elderly people.