Kaffeewelten. Historische Perspektiven auf eine globale Ware im 20. Jahrhundert

Kaffee war im 20. Jahrhundert wichtige Handelsware und heißgeliebtes Konsumgut. Der Sammelband beleuchtet Zusammenhänge und Widersprüche entlang der globalen Warenkette von Produktion, Handel und Konsum. Indigene Erntearbeiter in Mexiko, costaricanische Kleinbauern, Hamburger Importhändler, Röster, Konsumenten und Fair-Trade-Aktivisten stehen als historische Akteure im Zentrum. Geographisch erstreckt sich die Reichweite von Zentralamerika über Hamburg und die beiden deutschen Staaten bis nach Indien, Äthiopien und Brasilien. Das internationale Autorenteam präsentiert neue Forschungsergebnisse zur Wirtschafts-, Sozial- und Kulturgeschichte des Kaffees.

Ein jüdischer Kaufmann 1831 bis 1911 : Lebenserinnerungen

von Sigmund Mayer

Deutsch-Ostafrika als Einfuhr- und Ausfuhrmarkt

Aus: Berichte über Handel und Industrie ; 11

Die deutschen Kolonieen : für die Schüler von Lehrerbildungsanstalten

dargest. von F. Tschauder

PanDOI - Handle URI resolver

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Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse

The microrchidia, or morc, autosomal recessive mutation results in the arrest of spermatogenesis early in prophase I of meiosis. The morc mutation arose spontaneously during the development of a mouse strain transgenic for a tyrosinase cDNA construct. Morc −/− males are infertile and have grossly reduced testicular mass, whereas −/− females are normal, indicating that the Morc gene acts specifically during male gametogenesis. Immunofluorescence to synaptonemal complex antigens demonstrated that −/− male germ cells enter meiosis but fail to progress beyond zygotene or leptotene stage. An apoptosis assay revealed massive numbers of cells undergoing apoptosis in testes of −/− mice. No other abnormal phenotype was observed in mutant animals, with the exception of eye pigmentation caused by transgene expression in the retina. Spermatogenesis is normal in +/− males, despite significant transgene expression in germ cells. Genomic analysis of −/− animals indicates the presence of a deletion adjacent to the transgene. Identification of the gene inactivated by the transgene insertion may define a novel biochemical pathway involved in mammalian germ cell development and meiosis.

Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins

Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted from both chondrocytes and malignant melanoma cells. MIA has been reported to have effects on cell growth and adhesion, and it may play a role in melanoma metastasis and cartilage development. We report the 1.4-Å crystal structure of human MIA, which consists of an Src homology 3 (SH3)-like domain with N- and C-terminal extensions of about 20 aa each. The N- and C-terminal extensions add additional structural elements to the SH3 domain, forming a previously undescribed fold. MIA is a representative of a recently identified family of proteins and is the first structure of a secreted protein with an SH3 subdomain. The structure also suggests a likely protein interaction site and suggests that, unlike conventional SH3 domains, MIA does not recognize polyproline helices.

Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene.

Variability and complexity of phenotypes observed in microdeletion syndromes can be due to deletion of a single gene whose product participates in several aspects of development or can be due to the deletion of a number of tightly linked genes, each adding its own effect to the syndrome. The p6H deletion in mouse chromosome 7 presents a good model with which to address this question of multigene vs. single-gene pleiotropy. Mice homozygous for the p6H deletion are diluted in pigmentation, are smaller than their littermates, and manifest a nervous jerky-gait phenotype. Male homozygotes are sterile and exhibit profound abnormalities in spermiogenesis. By using N-ethyl-N-nitrosourea (EtNU) mutagenesis and a breeding protocol designed to recover recessive mutations expressed hemizygously opposite a large p-locus deletion, we have generated three noncomplementing mutations that map to the p6H deletion. Each of these EtNU-induced mutations has adverse effects on the size, nervous behavior, and progression of spermiogenesis that characterize p6H deletion homozygotes. Because EtNU is thought to induce primarily intragenic (point) mutations in mouse stem-cell spermatogonia, we propose that the trio of phenotypes (runtiness, nervous jerky gait, and male sterility) expressed in p6H deletion homozygotes is the result of deletion of a single highly pleiotropic gene. We also predict that a homologous single locus, quite possibly tightly linked and distal to the D15S12 (P) locus in human chromosome 15q11-q13, may be associated with similar developmental abnormalities in humans.

Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos.

Gold(I) salts and selenite, which have diverse therapeutic and biological effects, are noted for their reactivity with thiols. Since the binding of Jun-Jun and Jun-Fos dimers to the AP-1 DNA binding site is regulated in vitro by a redox process involving conserved cysteine residues, we hypothesized that some of the biological actions of gold and selenium are mediated via these residues. In electrophoretic mobility-shift analyses, AP-1 DNA binding was inhibited by gold(I) thiolates and selenite, with 50% inhibition occurring at approximately 5 microM and 1 microM, respectively. Thiomalic acid had no effect in the absence of gold(I), and other metal ions inhibited at higher concentrations, in a rank order correlating with their thiol binding affinities. Cysteine-to-serine mutants demonstrated that these effects of gold(I) and selenite require Cys272 and Cys154 in the DNA-binding domains of Jun and Fos, respectively. Gold(I) thiolates and selenite did not inhibit nonspecific protein binding to the AP-1 site and were at least an order of magnitude less potent as inhibitors of sequence-specific binding to the AP-2, TFIID, or NF1 sites compared with the AP-1 site. In addition, 10 microM gold(I) or 10 microM selenite inhibited expression of an AP-1-dependent reporter gene, but not an AP-2-dependent reporter gene. These data suggest a mechanism regulating transcription factor activity by inorganic ions which may contribute to the known antiarthritic action of gold and cancer chemoprevention by selenium.

Central Europe Region, 1787 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Neue Karte von Deutschland, Holland und der Schweiz, welche die merkwürdigsten Natur u. Kunst-Producte, den Handel, nebst der Volksmenge u. den Flächen Inhalt dieser Länder enthalt, entworfen und gezeichnet von J.E. Langen, Geom. et Geogr. It was published by J.E. Langen in 1787. Scale [ca. 1:2,140,000]. Covers the Central Europe region. Map in German. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Europe Lambert Conformal Conic coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, territorial and administrative boundaries, shoreline features, and more. Relief shown pictorially. Includes also text.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Magdeburg, Germany, ca. 1740 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Magdeburgum, ducatus cognominis metropolis ad Albium : sub ditione regis Borussiae, bene munitum ac florens emporium, in quo Tribunal Provinciale, consistorium et camera constituta = Magdeburg, die Haupt Statt eines Herzogthums gleiches Nahmens an der Elb, dem König in Preussen zustaendig, eine wohl fortificierte und florisante Handel Statt in welcher die Magdeburgische Landes Regierung, Consistorium und Camer angelegt, verfetigt von Matthaeus Seutter, Ihro Röm. Kaijserl. Maj. geographo. It was published by M. Seutter ca. 1740. Scale [ca. 1:5,000]. Covers Magdeburg, Germany. Map in Latin and German. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Deutsches Hauptdreiecksnetz (DHDN) 3-degree Gauss-Kruger Zone 4 coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, fortifications, ground cover, and more. Relief shown pictorially. Includes also index and panorama view of Magdeburg.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Cologne, Germany, 1740 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Colonia Agrippina antiquissima, maxima ac celeberrima libera imperii civitas et emporium florentissimum autore Matth�o Seutter Sac. C�s. et Reg. Cathol May Geogr. August = C�lln am Rhein eine uhralte sehr grose Hochber�hmte freye Reichs-und florisante Handel-Statt versertigt und heraus gegeben von Matth�us Seutter, Kaysrl. Georg: in Augspurg. It was published by Matt�o Seutter in 1740. Scale [ca. 1:8,200]. Covers Cologne, Germany. Map in Latin and German.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Deutsches Hauptdreiecksnetz (DHDN) 3-degree Gauss-Kruger Zone 2 coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as roads, drainage, built-up areas and selected buildings, fortification, ground cover, and more. Relief shown pictorially. Includes index, text and view below map: Agrippina C�lln am Rhein. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

University of Michigan Men's Tennis Team, 1991

Back Row (left to right): Head Coach Brian Eisner, Benji Hoffman, Scooter Place, John Lingon, Eric Grand, Terry London, trainer Hank Handel, assistant coach Tim Madden

Front Row: Dan Brakus, Mitch Rubenstein, John Karzen, captain David Kass, Geoff Baird, Peter Kim, Scott Cuppett

University of Michigan Men's Tennis Team, 1992

Top Row (left to right): Trainer Hank Handel, Eric Grand, Mike Nold, Grady Bumett, John Lingon, Greg Artz, Scooter Place, Chris Wyatt

Bottom Row: assistant coach Tim Madden, Sean King, Terry London, Mitch Rubenstein, David Kass, Dan Brakus, Adam Wager, head coach Brian Eisner

University of Michigan Field Hockey Team, 1991

Front Row: Nancy Irvine, Katie Epler, Katie Vignevic, co-captain Kristin Shaiper, co-captain Katie Thomas, co-captain Sandie Marotti, Katie Allison, Shay Perry.

Back Row: assistant coach Meri Dembrow, athletic trainer Hank Handel, Jennifer DiMascio, Kalli Hose, Chrissie Johnson, Stacy Daly. Nicole Hoover, Keely Libby, Mary Beth Bird, Lelli Hose, Jenny Ridgely, head coach Patti Smith.