Towards the Compilation of a Consistent Asian International I-O Table--The Report of the General Survey on National I-O Tables--

This paper reports on the survey of the characteristic features of national input-output tables compiled by the member countries of the Asian International Input-Output Table project. In making any inter-regional tables, the presentation format of each constituent table has to be carefully studied in order to design a common adjustment rule. The survey was conducted in the period of 2003-04, with invaluable cooperation from each collaborating institution of the project. Some analytical findings are drawn from the survey results, such as the similarity between each national table and the Japanese table, the responsiveness to the 1993 SNA, and the major areas of conflict regarding the presentation format.

Tratado de la Nobleza de la Corona de Aragon : especialmente del Reyno de Valencia, comparada con la de Castilla, para ilustracion de la Real Cedula del Señor Don Luis I de 14 de Agosto de 1724

Contiene: Apendice y coleccion de los documentos y notas pertencientes al Tratado de la nobleza de la Corona de Aragon ..

Illustre Marques de Aytona, &c. El Rey. Illustre Marques primo Lugarteniente i Capitan General, por parte de los Iurados de essa mi Ciudad de Valencia me ha sido hecha relacion de que ... les toca el avituallamiento de essa Ciudad ...

Tit. tomado de las primeras lineas del texto

A general method for determining helix packing in membrane proteins in situ: Helices I and II are close to helix VII in the lactose permease of Escherichia coli

It was previously shown that coexpression of the lactose permease of Escherichia coli in two contiguous fragments leads to functional complementation. We demonstrate here that site-directed thiol crosslinking of coexpressed permease fragments can be used to determine helix proximity in situ without the necessity of purifying the permease. After coexpression of the six N-terminal (N6) and six C-terminal (C6) transmembrane helices, each with a single Cys residue, crosslinking was carried out in native membranes and assessed by the mobility of anti-C-terminal-reactive polypeptides on immunoblots. A Cys residue at position 242 or 245 (helix VII) forms a disulfide with a Cys residue at either position 28 or 29 (helix I), but not with a Cys residue at position 27, which is on the opposite face of helix I, thereby indicating that the face of helix I containing Pro-28 and Phe-29 is close to helix VII. Similarly, a Cys residue at position 242 or 245 (helix VII) forms a disulfide with a Cys residue at either position 52 or 53 (helix II), but not with a Cys residue at position 54. Furthermore, low-efficiency crosslinking is observed between a Cys residue at position 52 or 53 and a Cys residue at position 361 (helix XI). The results indicate that helix VII lies in close proximity to both helices I and II and that helix II is also close to helix XI. The method should be applicable to a number of different polytopic membrane proteins.

Transloading of tumor cells with foreign major histocompatibility complex class I peptide ligand: a novel general strategy for the generation of potent cancer vaccines.

The major hurdle to be cleared in active immunotherapy of cancer is the poor immunogenicity of cancer cells. In previous attempts to overcome this problem, whole tumor cells have been used as vaccines, either admixed with adjuvant(s) or genetically engineered to express nonself proteins or immunomodulatory factors before application. We have developed a novel approach to generate an immunogeneic, highly effective vaccine: major histocompatibility complex (MHC) class I-positive cancer cells are administered together with MHC class I-matched peptide ligands of foreign, nonself origin, generated by a procedure we term transloading. Murine tumor lines of the H2-Kd or the H2-Db haplotype, melanoma M-3 and B16-F10, respectively, as well as colon carcinoma CT-26 (H2-Kd), were transloaded with MHC-matched influenza virus-derived peptides and applied as irradiated vaccines. Mice bearing a deposit of live M-3 melanoma cells were efficiently cured by this treatment. In the CT-26 colon carcinoma and the B16-F10 melanoma, high efficacies were obtained against tumor challenge, suggesting the universal applicability of this new type of vaccine. With foreign peptide ligands adapted to the requirements of a desired MHC class I haplotype, this concept may be used for the treatment of human cancers.

Propuestas transversales para la docencia en teoría y práctica de la Literatura Comparada (española / catalana)

Elaboración de prácticas presenciales i no presenciales en la asignatura de Teoría y Práctica de la Literatura Comparada, que se imparte en el Grado de Humanidades (códs. 29033 y 29034), tanto en español como en catalán, a partir de su proximidad literaria con otros ámbitos fronterizos, como pueden ser disciplinas artísticas y discursivas conexas. Antropología, historia, historia del arte, pensamiento o sociología serán claves en el desarrollo de esas actividades. Las temáticas a desarrollar corresponden a temas, tópicos y mitos literarios en diferentes literaturas: nacionalismo literario, canon, traducción, literaturas minoritarias y su relación con las artes. La intención es generar un amplio muestrario didáctico con el que desarrollar la asignatura para una tipología de alumnado con capacidad de conectar los más diferentes saberes humanísticos.